CAJ | 학술논문

目的：评价贝那普利对非增生期糖尿病视网膜病变的治疗作用。方法选取确诊为2型糖尿病合并早期糖尿病肾病并发非增生期糖尿病性视网膜病变患者29例，按随机数字表法分为贝那普利治疗组（12例）和常规治疗对照组（17例），于服药前、后3个月及6个月行收缩压、舒张压、空腹血糖、糖化血红蛋白、血肌酐、尿微量白蛋白、最佳矫正视力及眼底血管荧光造影检查，并对结果进行统计分析。结果贝那普利治疗组服药3个月后空腹血糖、糖化血红蛋白、血肌酐、尿微量白蛋白与服药前及常规治疗组差异无统计学意义（ P ＞0.05），收缩压、舒张压较服药前降低，但差异无统计学意义（ P ＞0.05）；贝那普利治疗组服药6个月后收缩压、舒张压、空腹血糖、糖化血红蛋白、血肌酐、尿微量白蛋白与服药前及常规治疗组比较差异均有统计学意义（ P ＜0.05）。根据最佳矫正视力及眼底血管荧光造影结果，发现经贝那普利治疗后的患者糖尿病性视网膜病变进展缓慢，与对照组同期比较差异有统计学意义（ P ＜0.05）。结论血管紧张素转换酶抑制剂贝那普利对非增生期糖尿病性视网膜病变具有一定的保护作用，从而延缓非增生期糖尿病性视网膜病变的进展，减少严重并发症发生。
목적：평개패나보리대비증생기당뇨병시망막병변적치료작용。방법선취학진위2형당뇨병합병조기당뇨병신병병발비증생기당뇨병성시망막병변환자29례，안수궤수자표법분위패나보리치료조（12례）화상규치료대조조（17례），우복약전、후3개월급6개월행수축압、서장압、공복혈당、당화혈홍단백、혈기항、뇨미량백단백、최가교정시력급안저혈관형광조영검사，병대결과진행통계분석。결과패나보리치료조복약3개월후공복혈당、당화혈홍단백、혈기항、뇨미량백단백여복약전급상규치료조차이무통계학의의（ P ＞0.05），수축압、서장압교복약전강저，단차이무통계학의의（ P ＞0.05）；패나보리치료조복약6개월후수축압、서장압、공복혈당、당화혈홍단백、혈기항、뇨미량백단백여복약전급상규치료조비교차이균유통계학의의（ P ＜0.05）。근거최가교정시력급안저혈관형광조영결과，발현경패나보리치료후적환자당뇨병성시망막병변진전완만，여대조조동기비교차이유통계학의의（ P ＜0.05）。결론혈관긴장소전환매억제제패나보리대비증생기당뇨병성시망막병변구유일정적보호작용，종이연완비증생기당뇨병성시망막병변적진전，감소엄중병발증발생。
Ojectvie To investigate therapeutic effect of benazepril on nonproliferative diabetic retinopathy ( NPDR) .Meth-ods Twenty nine patients with early diabetic nephropathy complicated with type 2 diabetes and NPDR were randomly divided into benazepril group ( n =12) and conventional therapy control group ( n =17).The changes of blood pressure , blood glucose, glycosy-lated hemoglobin , blood creatinine , urinary albumin , best corrected visual acuity ( BCVA ) , and fluorescein fundus angiography ( FFA) were observed before and after 3 and 6 months of treatment .Results After 3 months of treatment by benazepril , all laboratory detection parameters were no significant difference compared with before treatment and conventional therapy control group ( P >0.05);While after 6 months, compared with before treatment and control group , blood pressure, blood glucose, glycosylated hemoglo-bin, blood creatinine , and urinary albumin were significantly decreased ( P <0.05 ); According to the results of BCVA and FFA , progression of pathological changes of NPDR were significantly slower in benazepril group compared with control group ( P <0.05 ) . Conclusions Benazepril has some protection effect for NPDR to delay NPDR development and decrease serious complications .