南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2013年
10期
1551-1553
,共3页
郑育举%方晔%李绍金%郑邦希
鄭育舉%方曄%李紹金%鄭邦希
정육거%방엽%리소금%정방희
cofilin蛋白%肺癌%酶联免疫吸附法
cofilin蛋白%肺癌%酶聯免疫吸附法
cofilin단백%폐암%매련면역흡부법
cofilin protein%lung cancer%staging
目的检测肺癌患者血浆cofilin蛋白的含量,探讨其临床应用价值。方法分别抽取30例未手术肺癌患者及30例健康人的血液作为研究对象,采用酶联免疫吸附法(Elisa)检测上述血浆中cofilin蛋白含量,分析肺癌患者血浆cofilin蛋白含量与健康人血浆cofilin蛋白含量的差异。结果肺癌患者血浆中cofilin蛋白含量是0.485±0.465 ng/ml,健康人血浆cofilin蛋白含量0.203±0.102 ng/ml,两者比较有统计学差别(P<0.05)。Ⅲ、Ⅳ期肺癌患者血浆中cofilin蛋白含量0.744±0.584 ng/ml,Ⅱ期肺癌患者血浆中cofilin蛋白含量0.257±0.126 ng/ml,两者比较有统计学差别(P<0.05)。结论肺癌患者血浆cofilin蛋白的含量高于健康人血浆cofilin蛋白含量(P<0.05),提示血浆cofilin蛋白含量和肺癌相关。Ⅲ、Ⅳ期肺癌患者血浆中cofilin蛋白含量高于Ⅱ期肺癌患者,提示血浆cofilin蛋白含量和肺癌分期相关。
目的檢測肺癌患者血漿cofilin蛋白的含量,探討其臨床應用價值。方法分彆抽取30例未手術肺癌患者及30例健康人的血液作為研究對象,採用酶聯免疫吸附法(Elisa)檢測上述血漿中cofilin蛋白含量,分析肺癌患者血漿cofilin蛋白含量與健康人血漿cofilin蛋白含量的差異。結果肺癌患者血漿中cofilin蛋白含量是0.485±0.465 ng/ml,健康人血漿cofilin蛋白含量0.203±0.102 ng/ml,兩者比較有統計學差彆(P<0.05)。Ⅲ、Ⅳ期肺癌患者血漿中cofilin蛋白含量0.744±0.584 ng/ml,Ⅱ期肺癌患者血漿中cofilin蛋白含量0.257±0.126 ng/ml,兩者比較有統計學差彆(P<0.05)。結論肺癌患者血漿cofilin蛋白的含量高于健康人血漿cofilin蛋白含量(P<0.05),提示血漿cofilin蛋白含量和肺癌相關。Ⅲ、Ⅳ期肺癌患者血漿中cofilin蛋白含量高于Ⅱ期肺癌患者,提示血漿cofilin蛋白含量和肺癌分期相關。
목적검측폐암환자혈장cofilin단백적함량,탐토기림상응용개치。방법분별추취30례미수술폐암환자급30례건강인적혈액작위연구대상,채용매련면역흡부법(Elisa)검측상술혈장중cofilin단백함량,분석폐암환자혈장cofilin단백함량여건강인혈장cofilin단백함량적차이。결과폐암환자혈장중cofilin단백함량시0.485±0.465 ng/ml,건강인혈장cofilin단백함량0.203±0.102 ng/ml,량자비교유통계학차별(P<0.05)。Ⅲ、Ⅳ기폐암환자혈장중cofilin단백함량0.744±0.584 ng/ml,Ⅱ기폐암환자혈장중cofilin단백함량0.257±0.126 ng/ml,량자비교유통계학차별(P<0.05)。결론폐암환자혈장cofilin단백적함량고우건강인혈장cofilin단백함량(P<0.05),제시혈장cofilin단백함량화폐암상관。Ⅲ、Ⅳ기폐암환자혈장중cofilin단백함량고우Ⅱ기폐암환자,제시혈장cofilin단백함량화폐암분기상관。
Objective To detect serum content of cofilin protein in patients with lung cancer and investigate its clinical value. Methods The serum content of cofilin protein was detected in 30 cases of lung cancer and 30 healthy control subjects using enzyme-linked immunosorbent assay. Results The mean serum content of cofilin protein was 0.485 ± 0.465 ng/ml in patients with lung cancer and 0.203 ± 0.102 ng/ml in the control subjects, showing a significant difference between them (P<0.05). The content of cofilin protein in patients with stage III and IV lung cancer 0.744±0.584 ng/ml, significantly higher than that in stage II patients (0.257±0.126 ng/ml). Conclusion Serum cofilin protein is elevated in patients with lung cancer, especially in cases in advanced stages, suggesting its relation with lung cancer staging.