CAJ | 학술논문

目的比较人参超微粉与细粉中人参皂苷类成分的体外溶出度，探索粉体粒径对人参皂苷类成分溶出的影响，为人参入药时粉碎粒径的选择提供科学依据。方法采用浆法，运用高效液相色谱同时分析人参超微粉和细粉中5种人参皂苷成分的体外溶出情况，绘制溶出曲线，比较人参不同粒径粉末的溶出特征。结果人参超微粉与细粉相比，其人参皂苷类成分Re、Rg1、Rf、Rb1、Rb2具有更快的溶出速度，5 min内即能溶出总量的90%以上；人参超微粉与细粉中人参Re、Rf、Rb1、Rb2溶出总量无显著性差异；人参超微粉中Rg1溶出量较高（P<0.05）；但将人参超微粉与细粉均置于袋泡茶茶袋中时，人参细粉中5种人参皂苷反而比人参超微粉溶出快。结论超微粉碎能加快人参中人参皂苷类成分的溶出速度，提高Rg1溶出总量，但将其装入袋泡茶茶袋中时，人参超微粉中人参皂苷类成分反而比人参细粉溶出慢，因此在超微粉入药时，不宜选用袋泡茶剂型。
목적비교인삼초미분여세분중인삼조감류성분적체외용출도，탐색분체립경대인삼조감류성분용출적영향，위인삼입약시분쇄립경적선택제공과학의거。방법채용장법，운용고효액상색보동시분석인삼초미분화세분중5충인삼조감성분적체외용출정황，회제용출곡선，비교인삼불동립경분말적용출특정。결과인삼초미분여세분상비，기인삼조감류성분Re、Rg1、Rf、Rb1、Rb2구유경쾌적용출속도，5 min내즉능용출총량적90%이상；인삼초미분여세분중인삼Re、Rf、Rb1、Rb2용출총량무현저성차이；인삼초미분중Rg1용출량교고（P<0.05）；단장인삼초미분여세분균치우대포다다대중시，인삼세분중5충인삼조감반이비인삼초미분용출쾌。결론초미분쇄능가쾌인삼중인삼조감류성분적용출속도，제고Rg1용출총량，단장기장입대포다다대중시，인삼초미분중인삼조감류성분반이비인삼세분용출만，인차재초미분입약시，불의선용대포다제형。
Objective To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. Methods Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. Results The dissolution rates of ginsenosides from micropowder exceeded 90%within 5 min, significantly greater than that from common powder. But when the powders were packed in tea bags, the dissolution rates of ginsenosides were higher from common powder than from micropowder. Conclusion Micronization treatments can promote dissolution of ginsenosides from Ginseng.