国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
4期
394-397
,共4页
李素环(综述)%汪永红(审校)
李素環(綜述)%汪永紅(審校)
리소배(종술)%왕영홍(심교)
GnIH/GPR147%Kisspeptin/GPR54%促性腺激素释放激素%青春期
GnIH/GPR147%Kisspeptin/GPR54%促性腺激素釋放激素%青春期
GnIH/GPR147%Kisspeptin/GPR54%촉성선격소석방격소%청춘기
GnIH/GPR147%Kisspeptin/GPR54%GnRH%Puberty
小儿青春发育启动与下丘脑-垂体-性腺轴的发动有关,而下丘脑促性腺激素释放激素( gona-dotropin-releasing hormone,GnRH)神经元的激活是青春期启动的关键。青春期启动过程是一个复杂的过程,GnRH又受到许多相关神经肽调节的影响。近来研究发现促性腺激素抑制激素( gonadotropin-inhibitory hormone,GnIH)和 Kisspeptin 分别能够抑制和促进哺乳类动物的下丘脑 GnRH 的分泌,提示 GnIH 和Kisspeptin对生殖内分泌轴起着非常重要的调节作用。因此,GnIH/GPR147和Kisspeptin/GPR54两条通路可能与小儿青春发育启动密切相关。
小兒青春髮育啟動與下丘腦-垂體-性腺軸的髮動有關,而下丘腦促性腺激素釋放激素( gona-dotropin-releasing hormone,GnRH)神經元的激活是青春期啟動的關鍵。青春期啟動過程是一箇複雜的過程,GnRH又受到許多相關神經肽調節的影響。近來研究髮現促性腺激素抑製激素( gonadotropin-inhibitory hormone,GnIH)和 Kisspeptin 分彆能夠抑製和促進哺乳類動物的下丘腦 GnRH 的分泌,提示 GnIH 和Kisspeptin對生殖內分泌軸起著非常重要的調節作用。因此,GnIH/GPR147和Kisspeptin/GPR54兩條通路可能與小兒青春髮育啟動密切相關。
소인청춘발육계동여하구뇌-수체-성선축적발동유관,이하구뇌촉성선격소석방격소( gona-dotropin-releasing hormone,GnRH)신경원적격활시청춘기계동적관건。청춘기계동과정시일개복잡적과정,GnRH우수도허다상관신경태조절적영향。근래연구발현촉성선격소억제격소( gonadotropin-inhibitory hormone,GnIH)화 Kisspeptin 분별능구억제화촉진포유류동물적하구뇌 GnRH 적분비,제시 GnIH 화Kisspeptin대생식내분비축기착비상중요적조절작용。인차,GnIH/GPR147화Kisspeptin/GPR54량조통로가능여소인청춘발육계동밀절상관。
The initiation of puberty is associated with the hypothalamus-pituitary-gonadal( HPG) axis. The activation of gonadotropin-releasing hormone( GnRH) is the key factor in the initiation of puberty. The initi-ation of puberty is a complicated process,GnRH is under the influence of many associated neuropeptides. Re-cently,the studies have found that GnIH and Kisspeptin can respectively inhibit and promote the hypothalamus GnRH secretion of mammals,indicating that GnIH and Kisspeptin on regulation of reproductive endocrine axis play very important roles. Therefore,GnIH/GPR147 and Kisspeptin/GPR54 pathways may be closely associated with the initiation of puberty.
