国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2014年
4期
421-423
,共3页
王红%兰常肇%马少杰%张倩倩
王紅%蘭常肇%馬少傑%張倩倩
왕홍%란상조%마소걸%장천천
维生素D缺乏%喘息%儿童
維生素D缺乏%喘息%兒童
유생소D결핍%천식%인동
Vitamin D deficiency%Wheezing%Children
目的:探讨婴幼儿反复喘息与血清25-羟维生素D水平之间的相关性,并探讨婴幼儿反复喘息的相关危险因素。方法收集2012年10月至2013年3月在我院哮喘门诊就诊的反复喘息婴幼儿(6~36个月)61例为研究对象;另随机选取同期保健门诊健康婴幼儿(6~36个月)97例为对照组。采用化学发光免疫法测定各组儿童血清25羟-维生素 D的水平,完成病史采集、查体和实验室检查。结果反复喘息组患儿血清25-羟维生素D平均水平(14.38±4.35)μg/L,低于对照组血清25-羟维生素D平均水平(24.07±11.05)μg/L(F=33.39,P<0.001);反复喘息组血清25-羟维生素D≤20μg/L的发生率90%,而对照组11%,前者明显高于后者( P<0.001);多因素回归分析显示特应性过敏体质、吸烟接触史和血清25-羟维生素D≤20μg/L是婴幼儿反复喘息的危险因素( OR=9.89,95%CI 3.15~23.11)。结论婴幼儿反复喘息与血清低水平的25-羟维生素D相关。
目的:探討嬰幼兒反複喘息與血清25-羥維生素D水平之間的相關性,併探討嬰幼兒反複喘息的相關危險因素。方法收集2012年10月至2013年3月在我院哮喘門診就診的反複喘息嬰幼兒(6~36箇月)61例為研究對象;另隨機選取同期保健門診健康嬰幼兒(6~36箇月)97例為對照組。採用化學髮光免疫法測定各組兒童血清25羥-維生素 D的水平,完成病史採集、查體和實驗室檢查。結果反複喘息組患兒血清25-羥維生素D平均水平(14.38±4.35)μg/L,低于對照組血清25-羥維生素D平均水平(24.07±11.05)μg/L(F=33.39,P<0.001);反複喘息組血清25-羥維生素D≤20μg/L的髮生率90%,而對照組11%,前者明顯高于後者( P<0.001);多因素迴歸分析顯示特應性過敏體質、吸煙接觸史和血清25-羥維生素D≤20μg/L是嬰幼兒反複喘息的危險因素( OR=9.89,95%CI 3.15~23.11)。結論嬰幼兒反複喘息與血清低水平的25-羥維生素D相關。
목적:탐토영유인반복천식여혈청25-간유생소D수평지간적상관성,병탐토영유인반복천식적상관위험인소。방법수집2012년10월지2013년3월재아원효천문진취진적반복천식영유인(6~36개월)61례위연구대상;령수궤선취동기보건문진건강영유인(6~36개월)97례위대조조。채용화학발광면역법측정각조인동혈청25간-유생소 D적수평,완성병사채집、사체화실험실검사。결과반복천식조환인혈청25-간유생소D평균수평(14.38±4.35)μg/L,저우대조조혈청25-간유생소D평균수평(24.07±11.05)μg/L(F=33.39,P<0.001);반복천식조혈청25-간유생소D≤20μg/L적발생솔90%,이대조조11%,전자명현고우후자( P<0.001);다인소회귀분석현시특응성과민체질、흡연접촉사화혈청25-간유생소D≤20μg/L시영유인반복천식적위험인소( OR=9.89,95%CI 3.15~23.11)。결론영유인반복천식여혈청저수평적25-간유생소D상관。
Objective To investigate the level of serum 25(OH)D in children with recurrne t wheezing under the ageo f 36 months,and to explore ht e relta ed risk factors for recurrent wheezing under36 monthsof age.Methods Sixty-one children aged from 6~36 months who visited the asthma clinic from November 2012 to March 2013 with recurrent wheezing were selected for the recurrent wheezing group.Meanwhile ,97 children aged from 6~36 months who visited the healthcare clinic were selected for the control group.The serum 25 ( OH) D concentrations were measured by chemiluminescence immunoassay.Mde iac l history,physical examina-tion andl ba oratory data were collected.Results Teh serum 25(OH)D level in the recurrent wheezing group [(14.38 ±4.35)μg/L]were lower than the control group[(24.07 ±11.05)μg/L],Showing a signfi icant differenec (F=33.39,P<0.001).The incidence rate of plasm a 25(OH)D≤20μg/L in the recurrent wheezing group(90%)w ere higher than that of the control group(11%),showing a significant difference(P<0.001). Serum 25(OH) D ≤20 μg/L,allergy physique and smoking contact history were the risk factors for children with recurrent wheezing under 36 months(OR=9.89,95%CI 3.15~23.11).Conclusion Lowre serum vita-min D level might be assocait ed with the children with recurrent wheezing under 36 months.