CAJ | 학술논문

目的：探讨婴幼儿反复喘息与血清25-羟维生素D水平之间的相关性，并探讨婴幼儿反复喘息的相关危险因素。方法收集2012年10月至2013年3月在我院哮喘门诊就诊的反复喘息婴幼儿（6～36个月）61例为研究对象；另随机选取同期保健门诊健康婴幼儿（6～36个月）97例为对照组。采用化学发光免疫法测定各组儿童血清25羟-维生素 D的水平，完成病史采集、查体和实验室检查。结果反复喘息组患儿血清25-羟维生素D平均水平（14.38±4.35）μg/L，低于对照组血清25-羟维生素D平均水平（24.07±11.05）μg/L（F＝33.39，P＜0.001）；反复喘息组血清25-羟维生素D≤20μg/L的发生率90％，而对照组11％，前者明显高于后者（ P＜0.001）；多因素回归分析显示特应性过敏体质、吸烟接触史和血清25-羟维生素D≤20μg/L是婴幼儿反复喘息的危险因素（ OR＝9.89，95％CI 3.15～23.11）。结论婴幼儿反复喘息与血清低水平的25-羟维生素D相关。
목적：탐토영유인반복천식여혈청25-간유생소D수평지간적상관성，병탐토영유인반복천식적상관위험인소。방법수집2012년10월지2013년3월재아원효천문진취진적반복천식영유인（6～36개월）61례위연구대상；령수궤선취동기보건문진건강영유인（6～36개월）97례위대조조。채용화학발광면역법측정각조인동혈청25간-유생소 D적수평，완성병사채집、사체화실험실검사。결과반복천식조환인혈청25-간유생소D평균수평（14.38±4.35）μg/L，저우대조조혈청25-간유생소D평균수평（24.07±11.05）μg/L（F＝33.39，P＜0.001）；반복천식조혈청25-간유생소D≤20μg/L적발생솔90％，이대조조11％，전자명현고우후자（ P＜0.001）；다인소회귀분석현시특응성과민체질、흡연접촉사화혈청25-간유생소D≤20μg/L시영유인반복천식적위험인소（ OR＝9.89，95％CI 3.15～23.11）。결론영유인반복천식여혈청저수평적25-간유생소D상관。
Objective To investigate the level of serum 25(OH)D in children with recurrne t wheezing under the ageo f 36 months,and to explore ht e relta ed risk factors for recurrent wheezing under36 monthsof age.Methods Sixty-one children aged from 6~36 months who visited the asthma clinic from November 2012 to March 2013 with recurrent wheezing were selected for the recurrent wheezing group.Meanwhile ,97 children aged from 6~36 months who visited the healthcare clinic were selected for the control group.The serum 25 ( OH) D concentrations were measured by chemiluminescence immunoassay.Mde iac l history,physical examina-tion andl ba oratory data were collected.Results Teh serum 25(OH)D level in the recurrent wheezing group [(14.38 ±4.35)μg/L]were lower than the control group[(24.07 ±11.05)μg/L],Showing a signfi icant differenec (F=33.39,P<0.001).The incidence rate of plasm a 25(OH)D≤20μg/L in the recurrent wheezing group(90%)w ere higher than that of the control group(11%),showing a significant difference(P<0.001). Serum 25(OH) D ≤20 μg/L,allergy physique and smoking contact history were the risk factors for children with recurrent wheezing under 36 months(OR=9.89,95%CI 3.15~23.11).Conclusion Lowre serum vita-min D level might be assocait ed with the children with recurrent wheezing under 36 months.