中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2014年
7期
4139-4139
,共1页
慢性阻塞性肺疾病%D-乳酸%肠脂肪酸结合蛋白%C-反应蛋白
慢性阻塞性肺疾病%D-乳痠%腸脂肪痠結閤蛋白%C-反應蛋白
만성조새성폐질병%D-유산%장지방산결합단백%C-반응단백
chronic obstructive pulmonary disease%D-lactate%intestinal faty acid binding protein%C-reactive protein
目的：探讨血清D-乳酸、肠脂肪酸结合蛋白(I-FABP)和C-反应蛋白(CRP)水平在慢性阻塞性肺疾病急性加重期(AECOPD)中的变化及临床意义，了解AECOPD患者早期肠黏膜损伤和通透性变化及其与系统性炎症反应关系。方法：将54例AECOPD患者和18例COPD稳定期体检者作为观察组和对照组，观察组分为通气组及非通气组，定量检测血清D-乳酸、I-FABP及CRP水平并分析。结果：血清D-乳酸、I-FABP及CRP水平在观察组显著高于对照组(P﹤0.01)，非通气组低于通气组但高于对照组(P﹤0.01)；相关分析显示观察组血清D-乳酸、I-FABP与CRP均呈正相关。结论：AECOPD早期存在肠黏膜损伤及通透性变化，病情越重肠黏膜损伤越重，其与系统性炎症反应密切相关。
目的：探討血清D-乳痠、腸脂肪痠結閤蛋白(I-FABP)和C-反應蛋白(CRP)水平在慢性阻塞性肺疾病急性加重期(AECOPD)中的變化及臨床意義，瞭解AECOPD患者早期腸黏膜損傷和通透性變化及其與繫統性炎癥反應關繫。方法：將54例AECOPD患者和18例COPD穩定期體檢者作為觀察組和對照組，觀察組分為通氣組及非通氣組，定量檢測血清D-乳痠、I-FABP及CRP水平併分析。結果：血清D-乳痠、I-FABP及CRP水平在觀察組顯著高于對照組(P﹤0.01)，非通氣組低于通氣組但高于對照組(P﹤0.01)；相關分析顯示觀察組血清D-乳痠、I-FABP與CRP均呈正相關。結論：AECOPD早期存在腸黏膜損傷及通透性變化，病情越重腸黏膜損傷越重，其與繫統性炎癥反應密切相關。
목적：탐토혈청D-유산、장지방산결합단백(I-FABP)화C-반응단백(CRP)수평재만성조새성폐질병급성가중기(AECOPD)중적변화급림상의의，료해AECOPD환자조기장점막손상화통투성변화급기여계통성염증반응관계。방법：장54례AECOPD환자화18례COPD은정기체검자작위관찰조화대조조，관찰조분위통기조급비통기조，정량검측혈청D-유산、I-FABP급CRP수평병분석。결과：혈청D-유산、I-FABP급CRP수평재관찰조현저고우대조조(P﹤0.01)，비통기조저우통기조단고우대조조(P﹤0.01)；상관분석현시관찰조혈청D-유산、I-FABP여CRP균정정상관。결론：AECOPD조기존재장점막손상급통투성변화，병정월중장점막손상월중，기여계통성염증반응밀절상관。
To assess the serum levels of D-lactate, intestinal faty acid binding protein(I-FABP),C-reactive protein(CRP),and to analyze its relationship with systemic inflammatory response in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Subjects were divided into ventilation group,no-ventilation group and control group according to the standard.Then the serum D-lactate,I-FABP and CRP of al the subjects were detected and analyzed.Results:The serum levels of D-lactate,I-FABP and CRP in ventilation group and no-ventilation group were higher than those in control group(P﹤0.01);and those in ventilation group were higher than those in no-ventilation group(P﹤0.01).There were positive correlations between the serum levels of D-lactate,I-FABP and CRP in observation group.Conclusion:Intestinal mucosa barrier may have been injured in patients with AECOPD,and would get worse as the severity of AECOPD increase; A positive association was present between intestinal mucosal injury and systemic inflammatory response.
