CAJ | 학술논문

目的：对不同类型胃黏膜活检组织1A6/ DRIM 表达和血清 MG7- Ag 检测，探讨两者的相关性及胃癌前病变风险预测的临床应用价值。方法：131例胃黏膜活检组织及其血清标本（浅表性胃炎30例，胃黏膜糜烂溃疡26例，萎缩性胃炎伴肠上皮化生21例，胃癌54例），采用酶联免疫吸附实验（ELISA）检测血清 MG7- Ag 含量；免疫组化 SP 法检测胃黏膜组织标本中1A6/ DRIM 的表达水平。结果：从浅表性胃炎、胃黏膜糜烂溃疡、萎缩性胃炎伴肠上皮化生到胃癌，血清 MG7- Ag 含量呈逐渐升高趋势，并且各组间比较差异均有显著性（P ﹤0.05），胃癌患者血清 MG7- Ag 含量明显高于其他胃病患者，差异有显著性（P ﹤0.01）。1A6/ DRIM在54例胃癌组织中阳性表达34例（63.0%），在其他胃病患者中阳性表达9例（11.7%），差异有显著性（P ﹤0.05）。随着病变组织中1A6/ DRIM 表达的上升，血清 MG7- Ag 含量有上升趋势，两者具有良好的相关性（rs=0.346，P =0.001）。血清 MG7- Ag 和1A6/ DRIM 组织表达水平与胃癌分化程度呈负相关，二者有良好的相关性。结论：MG7- Ag 可以作为胃癌的血清学检测指标，对早期胃癌进行筛查，结合组织学1A6/ DRIM 基因表达的检查，有助于胃癌高危个体的筛查和诊断，提高胃癌早期诊断水平。
목적：대불동류형위점막활검조직1A6/ DRIM 표체화혈청 MG7- Ag 검측，탐토량자적상관성급위암전병변풍험예측적림상응용개치。방법：131례위점막활검조직급기혈청표본（천표성위염30례，위점막미란궤양26례，위축성위염반장상피화생21례，위암54례），채용매련면역흡부실험（ELISA）검측혈청 MG7- Ag 함량；면역조화 SP 법검측위점막조직표본중1A6/ DRIM 적표체수평。결과：종천표성위염、위점막미란궤양、위축성위염반장상피화생도위암，혈청 MG7- Ag 함량정축점승고추세，병차각조간비교차이균유현저성（P ﹤0.05），위암환자혈청 MG7- Ag 함량명현고우기타위병환자，차이유현저성（P ﹤0.01）。1A6/ DRIM재54례위암조직중양성표체34례（63.0%），재기타위병환자중양성표체9례（11.7%），차이유현저성（P ﹤0.05）。수착병변조직중1A6/ DRIM 표체적상승，혈청 MG7- Ag 함량유상승추세，량자구유량호적상관성（rs=0.346，P =0.001）。혈청 MG7- Ag 화1A6/ DRIM 조직표체수평여위암분화정도정부상관，이자유량호적상관성。결론：MG7- Ag 가이작위위암적혈청학검측지표，대조기위암진행사사，결합조직학1A6/ DRIM 기인표체적검사，유조우위암고위개체적사사화진단，제고위암조기진단수평。
To study serum content of MG7 - Ag as well as 1A6 / DRIM expression in various types of gastric mucosa biopsy tissues and their correlation. Methods:For 131 samples of gastric mucosa biopsy tissues and corresponding sera(30 samples of superficial gastritis,26 samples of gastric mucosal erosion and ulcer,21 samples of atrophic gastritis and dysplasia,54 samples of gastric cancer),serum content of MG7 - Ag was detected by enzyme -linked immunosorbent assay(ELISA),1A6 / DRIM expression in tissues was detected by SP immunohistochemical. Results:In the order of superficial gastritis,gastric mucosal erosion and ulcer,atrophic gastritis and dysplasia and gas-tric cancer,serum content of MG7 - Ag increased sequentially(P ﹤ 0. 05),there was significantly statistical differ-ences among the groups(P ﹤ 0. 01),the positive rate of 1A6 / DRIM expression in 54 gastric carcinomas was 63. 0% , while the positive rate in gastric precancerous lesions was 11. 7% ,a significant difference existed between them,a close correlation existed between 1A6 / DRIM in situ expression and MG7 - Ag in serum content. Dynamic expression of MG7 - Ag in gastric diseases suggests that malignancy degree of gastric mucosa cells is in association with MG7 -Ag expression and there was a closed correlation between MG7 - Ag in serum and expression of 1A6 / DRIM in tis-sues. Conclusion:It is suggested that MG7 - Ag may play a role in the prediction of gastric precancerous lesions and early diagnosis of gastric cancer. Detection of MG7 - Ag in serum samples could offer a more convenient assay to mo-nitor the disease progress and be extensively applied in the clinic.