CAJ | 학술논문

川芎嗪药理作用广泛，临床上用于治疗心脑血管疾病、呼吸系统疾病、泌尿系统疾病、肝硬化、肿瘤等。近年来，川芎嗪对脊髓损伤的保护作用相关研究也逐年增多。大量临床试验和动物实验显示，川芎嗪对缺血性脑血管病、脑退行性疾病、癫痫及脊髓损伤等有保护作用，其主要机制包括抑制细胞凋亡和炎症反应、提高机体的抗氧化水平、改善血液流变学、增加神经丝蛋白和神经营养因子表达、调节细胞内外离子平衡。本文查阅了2003年至今的相关文献，对近10年来川芎嗪对脑和脊髓损伤的保护作用及其机制研究进行综述。
천궁진약리작용엄범，림상상용우치료심뇌혈관질병、호흡계통질병、비뇨계통질병、간경화、종류등。근년래，천궁진대척수손상적보호작용상관연구야축년증다。대량림상시험화동물실험현시，천궁진대결혈성뇌혈관병、뇌퇴행성질병、전간급척수손상등유보호작용，기주요궤제포괄억제세포조망화염증반응、제고궤체적항양화수평、개선혈액류변학、증가신경사단백화신경영양인자표체、조절세포내외리자평형。본문사열료2003년지금적상관문헌，대근10년래천궁진대뇌화척수손상적보호작용급기궤제연구진행종술。
Ligustrazine which has extensive pharmacological effects has been clinically used in the treatment of cardiovascular and cerebrovascular diseases,respiratory diseases,urinary diseases,cirrhosis,cancer,etc.Research of protective effects of Ligustrazine on spinal cord injury has recently increased year by year.Numerous clinical trials and animal experiments suggest that Ligustrazine can play a role on ischemic cerebrovascular disease, degenerative brain disease,epilepsy,spinal cord injury and so on,whose main mechanisms include inhibiting of apoptosis and inflammation,enhancing the body’s antioxidant level,improving hemorheology,increasing expression of neurofilament protein and neurotrophic factors,and regulating balance of the ion intracellular and extracellular.Through consulting the relevant literature since 2003,this article reviews the protective roles and mechanisms of Ligustrazine on cerebra and spinal cord injury for the past 10 years.