中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2014年
4期
349-352
,共4页
王建%史瑞%王连江%吴迪%崔子林%李阳%侯建存%田青%刘晓龙%张雅敏
王建%史瑞%王連江%吳迪%崔子林%李暘%侯建存%田青%劉曉龍%張雅敏
왕건%사서%왕련강%오적%최자림%리양%후건존%전청%류효룡%장아민
门冬氨酸鸟氨酸%肝切除%肝硬化肝癌%肝功能恢复
門鼕氨痠鳥氨痠%肝切除%肝硬化肝癌%肝功能恢複
문동안산조안산%간절제%간경화간암%간공능회복
L-ornithine-L-aspartate%hepatectomy%hepatocellular carcinoma with liver cirrhosis%liver function recovery
目的：观察门冬氨酸鸟氨酸(LOLA)对肝癌合并肝硬化半肝切除术后肝功能的影响。方法：通过随机、对照的方法，将66例肝癌合并肝硬化行半肝切除患者分为2组，仅治疗组于术后1~7 d静脉应用LOLA。全部患者分别在术前及术后1、3、5、7、10、14 d抽外周静脉血检查谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TB）、直接胆红素（DB）。结果：治疗组术后1、3、5 d ALT明显低于对照组(P＜0.05)，术后3、5 d AST明显低于对照组(P＜0.05)。治疗组术后7 d ALT恢复正常的比率高于对照组。LOLA对术后TB、DB无影响。两组术后肝功能不全的发生率无差异(P=0.557)。结论：LOLA能促进肝癌肝硬化半肝切除术后肝脏功能的早期恢复。
目的：觀察門鼕氨痠鳥氨痠(LOLA)對肝癌閤併肝硬化半肝切除術後肝功能的影響。方法：通過隨機、對照的方法，將66例肝癌閤併肝硬化行半肝切除患者分為2組，僅治療組于術後1~7 d靜脈應用LOLA。全部患者分彆在術前及術後1、3、5、7、10、14 d抽外週靜脈血檢查穀丙轉氨酶（ALT）、穀草轉氨酶（AST）、總膽紅素（TB）、直接膽紅素（DB）。結果：治療組術後1、3、5 d ALT明顯低于對照組(P＜0.05)，術後3、5 d AST明顯低于對照組(P＜0.05)。治療組術後7 d ALT恢複正常的比率高于對照組。LOLA對術後TB、DB無影響。兩組術後肝功能不全的髮生率無差異(P=0.557)。結論：LOLA能促進肝癌肝硬化半肝切除術後肝髒功能的早期恢複。
목적：관찰문동안산조안산(LOLA)대간암합병간경화반간절제술후간공능적영향。방법：통과수궤、대조적방법，장66례간암합병간경화행반간절제환자분위2조，부치료조우술후1~7 d정맥응용LOLA。전부환자분별재술전급술후1、3、5、7、10、14 d추외주정맥혈검사곡병전안매（ALT）、곡초전안매（AST）、총담홍소（TB）、직접담홍소（DB）。결과：치료조술후1、3、5 d ALT명현저우대조조(P＜0.05)，술후3、5 d AST명현저우대조조(P＜0.05)。치료조술후7 d ALT회복정상적비솔고우대조조。LOLA대술후TB、DB무영향。량조술후간공능불전적발생솔무차이(P=0.557)。결론：LOLA능촉진간암간경화반간절제술후간장공능적조기회복。
Objective To investigate the effect of L-ornithine-L-aspartate on liver fuction after hemihepa-tectomy in patients with hepatocellular carcinoma and liver cirrhosis. Methods The clinical data of 66 pa-tients receiving hepatectomy were analyzed. The patients were divided into the experimental group (n=33) and control group (n=33). L-ornithine-L-aspartate was injected intravenously in the experimental group from the 1st to the 7th day after operation. The blood levels of serum alanine aminotransferase (ALT), aspartic acid amino-transferase (AST), total bilirubin (TB) and direct bilirubin (DB) were detected at day 1,3,5,7,10,14 after opera-tion. Results In the experimental group,the levels of AST on 1st,3rd and 5th day and of ALT on 3rd and 5th day after operation were significantly lower in the experimental group than those in the control group (P<0.05). On the postoperative day 7,the ratio of serum ALT in the experimental group returned to normal was sig-nificantly higher than that in the control group (P<0.05). There was no difference between the 2 groups in the levels of TB and DB after operation. The incidence of liver failure after operation was slightly lower in the experi-mental group than that in the control group (P=0. 557). Conclusion L-ornithine-L-aspartate can alleviate the hepatic dysfunction after hemihepatectomy,and has protective advantage for liver function in the periopera-tive period of hemihepatectomy.
