CAJ | 학술논문

目的：探讨ANA阴性的SLE患者临床及肾脏病理特征。方法：对至少有两年随访纪录的363例SLE 患者的病例资料进行回顾分析。结果：35例ANA阴性（9．6％），328例ANA阳性（90．4％），与ANA阳性组比较，ANA阴性组光过敏（37．1％）及抗SSA抗体（60．0％）发生率较高，而肾损害（57．1％）、关节炎（42．9％）及抗ds-DNA抗体（42．9％）的发生率则较低；其中68例患者进行了肾穿刺活检，两组肾脏病理类型总体分布无显著差异（P＞0．05）。结论：ANA阴性的SLE患者光过敏常见，抗SSA抗体阳性率较高，而肾损害相对少见。
목적：탐토ANA음성적SLE환자림상급신장병리특정。방법：대지소유량년수방기록적363례SLE 환자적병례자료진행회고분석。결과：35례ANA음성（9．6％），328례ANA양성（90．4％），여ANA양성조비교，ANA음성조광과민（37．1％）급항SSA항체（60．0％）발생솔교고，이신손해（57．1％）、관절염（42．9％）급항ds-DNA항체（42．9％）적발생솔칙교저；기중68례환자진행료신천자활검，량조신장병리류형총체분포무현저차이（P＞0．05）。결론：ANA음성적SLE환자광과민상견，항SSA항체양성솔교고，이신손해상대소견。
Objective:To investigate the clinical and renal pathologic features of ANA-negative SLE.Methods:Retrospective analysis 363 cases material of SLE patients who had at least two years follow-up-notes.Results:There were 35 ANA negative(9.6%)and 328 ANA positive(90.4%)SLE patients.Com-pared with the ANA positive group,the probabilities of occurrence of photosensitivity(37.1%)and anti-SSA(60.0%)were higher in the ANA negative group, while occurrence of kidney damage(57.1%),arthritis(42.9%)and anti-dsDNA(42.9%)were lower.Among these patients,68 patients were accepted renal biopsy.Analyzed the general distribution of renal pathological type,there was no difference between the two groups(P>0.05).Conclusion:The ANA-negative SLE patients have commonly photosensitivity and high incidence of positive anti-SSA,while kidney damage is relatively uncommon.