中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
17期
128-130
,共3页
甲磺酸伊马替尼%衍生化%气相色谱%甲磺酸甲酯%甲磺酸乙酯%甲磺酸异丙酯
甲磺痠伊馬替尼%衍生化%氣相色譜%甲磺痠甲酯%甲磺痠乙酯%甲磺痠異丙酯
갑광산이마체니%연생화%기상색보%갑광산갑지%갑광산을지%갑광산이병지
Imatinib mesylate%Derivatization%GC%MMS%EMS%IMS
目的建立衍生气相色谱法同时检测甲磺酸伊马替尼中的甲磺酸甲酯、甲磺酸乙酯、甲磺酸异丙酯三种甲磺酸烷基酯。方法采用NaI-H2O碘化衍生,利用ZB-WAX石英毛细管柱(30m×0.53mm,1.0μm)分离,氢火焰离子化(FID)检测器。结果方法在0.070~13.0μg/mL具有良好的线性(r>0.999),检出限0.2ppm,回收率94.1%~111.3%。结论该方法可用于甲磺酸伊马替尼中甲磺酸甲酯、甲磺酸乙酯、甲磺酸异丙酯三种甲磺酸烷基酯成分的同时碘化衍生分离分析,方法简便,结果可靠、重现性好。
目的建立衍生氣相色譜法同時檢測甲磺痠伊馬替尼中的甲磺痠甲酯、甲磺痠乙酯、甲磺痠異丙酯三種甲磺痠烷基酯。方法採用NaI-H2O碘化衍生,利用ZB-WAX石英毛細管柱(30m×0.53mm,1.0μm)分離,氫火燄離子化(FID)檢測器。結果方法在0.070~13.0μg/mL具有良好的線性(r>0.999),檢齣限0.2ppm,迴收率94.1%~111.3%。結論該方法可用于甲磺痠伊馬替尼中甲磺痠甲酯、甲磺痠乙酯、甲磺痠異丙酯三種甲磺痠烷基酯成分的同時碘化衍生分離分析,方法簡便,結果可靠、重現性好。
목적건립연생기상색보법동시검측갑광산이마체니중적갑광산갑지、갑광산을지、갑광산이병지삼충갑광산완기지。방법채용NaI-H2O전화연생,이용ZB-WAX석영모세관주(30m×0.53mm,1.0μm)분리,경화염리자화(FID)검측기。결과방법재0.070~13.0μg/mL구유량호적선성(r>0.999),검출한0.2ppm,회수솔94.1%~111.3%。결론해방법가용우갑광산이마체니중갑광산갑지、갑광산을지、갑광산이병지삼충갑광산완기지성분적동시전화연생분리분석,방법간편,결과가고、중현성호。
Objective To establish a derivative gas chromatography method simultaneously quantitative determination of methyl methanesulfonate(MMS), ethyl methanesulfonate(EMS), isopropyl methanesulfonate(IMS) in imatinib mesylate. Methods NaI-H2O solution as the iodonation agent, ZB-WAX(30m×0.53mm,1.0μm)capillary column was used to separate the fatty acids an d FID for quantitative decermination. Results Excellent linearity shc1wed within the range of 0.070-13.0μg/mL(r > 0.999),detection limit was 0.2ppm,and the recovery rate was 94.1%-111.3%. Conclusion The method shows satisfactory repeatability, simplicity and convenience, and is valid in simultaneous derivation separation and analysis of these methanesulfonic acid alkyl ester in imatinib mesylate.