CAJ | 학술논문

目的：探讨环氧化酶-2（cyclooxygenase-2，COX-2）与增殖细胞核抗原（proliferating cell nuclear antigen， PCNA）在腺性膀胱炎中的表达及其临床意义。方法应用免疫组织化学方法，检测20例正常膀胱黏膜、30例腺性膀胱炎、20例膀胱移行细胞癌中COX-2及PCNA的表达。结果 COX-2在腺性膀胱炎中表达阳性率比其在正常膀胱黏膜中表达的阳性率有所增高，比其在膀胱移行细胞癌中表达的阳性率有所降低，但均无统计学意义（ P ＞0/．05）；PC-NA在腺性膀胱炎中表达的阳性率显著高于其在正常膀胱黏膜中表达的阳性率（ P ＜0．05），与其在膀胱移行细胞癌中表达的阳性率比较，有所降低，但差异无统计学意义（ P ＞0．05）。 COX-2和PCNA在膀胱移行细胞癌中表达的阳性率均显著高于其在正常膀胱黏膜中表达的阳性率（ P ＜0．05）。结论 COX-2及PCNA的表达在膀胱肿瘤的发生中起重要作用，推测腺性膀胱炎为良性病变，有向恶性病变发展的潜能，COX-2及PCNA在研究腺性膀胱炎与膀胱肿瘤的关系中具有重要意义。
목적：탐토배양화매-2（cyclooxygenase-2，COX-2）여증식세포핵항원（proliferating cell nuclear antigen， PCNA）재선성방광염중적표체급기림상의의。방법응용면역조직화학방법，검측20례정상방광점막、30례선성방광염、20례방광이행세포암중COX-2급PCNA적표체。결과 COX-2재선성방광염중표체양성솔비기재정상방광점막중표체적양성솔유소증고，비기재방광이행세포암중표체적양성솔유소강저，단균무통계학의의（ P ＞0/．05）；PC-NA재선성방광염중표체적양성솔현저고우기재정상방광점막중표체적양성솔（ P ＜0．05），여기재방광이행세포암중표체적양성솔비교，유소강저，단차이무통계학의의（ P ＞0．05）。 COX-2화PCNA재방광이행세포암중표체적양성솔균현저고우기재정상방광점막중표체적양성솔（ P ＜0．05）。결론 COX-2급PCNA적표체재방광종류적발생중기중요작용，추측선성방광염위량성병변，유향악성병변발전적잠능，COX-2급PCNA재연구선성방광염여방광종류적관계중구유중요의의。
Objective To explore the expression and clinical significance of cyclooxygenase -2 ( COX-2 ) and proliferating cell nuclear antigen (PCNA) in cystitis glandularis.Methods The immunohistochemistry was used to examine the expression levels of COX-2 and PCNA in 20 cases of normal mucosa of bladder ,30 cases of cystitis glandularis and 20 cases of transitional cell carcinoma of bladder .Results The positive expression rate of COX-2 in cystitis glandularis was 30%(9/30),which was higher than that in normal mucosa of bladder (5%,1/20),however,which was lower than that in transitional cell carcinoma of bladder (55%,11/20),but there were no significances among them ( P >0.05).The positive expression rate of PCNA in cystitis glandularis was 26.67%(8/30),which was significantly higher than that in normal mucosa of bladder (0,0/20) ( P <0.05),which was lower than that in transitional cell carcinoma of bladder ,but there was no significant difference among them ( P >0.05).The positive expression rates both COX-2 and PCNA in transitional cell carcinoma of bladder were significantly higher than those in normal mucosa of bladder ( P <0.05).Conclusion The expression of COX-2 and PCNA plays an important role in the pathogenesis of bladder neoplasms , and cystitis glandularis is benign lesion,however,which has potentiality to become malignant lesion ,so the study about the correlation between expression of COX-2,PCNA in cystitis glandularis and pathogenesis of bladder neoplasms has important significance .