河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
10期
1456-1457,1458
,共3页
大黄%姜黄%配伍%血脂
大黃%薑黃%配伍%血脂
대황%강황%배오%혈지
rhubarb%curcuma%compatibility%blood fat
目的：观察大黄乙醇提取物与姜黄乙醇提取物单味应用与伍用对实验性高脂血症小鼠血清中TG、TC、HDL-C、LDL-C的影响，探索2种提取物单用与伍用降血脂作用的差异。方法选体重20～25 g昆明种雄性小鼠，分为5组，对照组、模型组、大黄组、姜黄组、大黄姜黄1∶1伍用组，5组在同一时间开始灌胃0 W．9％氯化钠溶液、脂肪乳剂、大黄乙醇提取物混悬液，姜黄乙醇提取物混悬液，大黄姜黄1∶1乙醇提取物混悬液，28 d后测血脂。结果大黄与姜黄单用、伍用均有降血脂作用（ P ＜0．05）。结论大黄乙醇提取物、姜黄乙醇提取物、大黄与姜黄乙醇提取物按1∶1伍用均能使实验性高脂血症小鼠血脂降低，大黄与姜黄乙醇提取物按1∶1比例伍用降脂效果优于单味药提取物。
目的：觀察大黃乙醇提取物與薑黃乙醇提取物單味應用與伍用對實驗性高脂血癥小鼠血清中TG、TC、HDL-C、LDL-C的影響，探索2種提取物單用與伍用降血脂作用的差異。方法選體重20～25 g昆明種雄性小鼠，分為5組，對照組、模型組、大黃組、薑黃組、大黃薑黃1∶1伍用組，5組在同一時間開始灌胃0 W．9％氯化鈉溶液、脂肪乳劑、大黃乙醇提取物混懸液，薑黃乙醇提取物混懸液，大黃薑黃1∶1乙醇提取物混懸液，28 d後測血脂。結果大黃與薑黃單用、伍用均有降血脂作用（ P ＜0．05）。結論大黃乙醇提取物、薑黃乙醇提取物、大黃與薑黃乙醇提取物按1∶1伍用均能使實驗性高脂血癥小鼠血脂降低，大黃與薑黃乙醇提取物按1∶1比例伍用降脂效果優于單味藥提取物。
목적：관찰대황을순제취물여강황을순제취물단미응용여오용대실험성고지혈증소서혈청중TG、TC、HDL-C、LDL-C적영향，탐색2충제취물단용여오용강혈지작용적차이。방법선체중20～25 g곤명충웅성소서，분위5조，대조조、모형조、대황조、강황조、대황강황1∶1오용조，5조재동일시간개시관위0 W．9％록화납용액、지방유제、대황을순제취물혼현액，강황을순제취물혼현액，대황강황1∶1을순제취물혼현액，28 d후측혈지。결과대황여강황단용、오용균유강혈지작용（ P ＜0．05）。결론대황을순제취물、강황을순제취물、대황여강황을순제취물안1∶1오용균능사실험성고지혈증소서혈지강저，대황여강황을순제취물안1∶1비례오용강지효과우우단미약제취물。
Objectives To investigate the effects of single rhubarb ethanol extract , single curcuma ethanol extract , compatibility application on the serum levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) of mice with hyperlipidemia in order to explore the differences of hypolipidemic effects of the two kinds of drugs between single application and compatibility application .Mtehods Seventy male Kunming mice weighted 20~25 g were randomly divided into five groups:control group,model group,rhubarb group, curcuma group,rhubarb +curcuma (1∶1 compatibility) group.The mice in the five groups were given 0.9%sodium chloride solution,fat emulsion,rhubarb ethanol extract suspension ,curcuma ethanol extract suspension ,rhubarb +curcuma (1∶1) ethanol extract suspension,respectively by gavage at the same time ,after 28 days,the blood fat levels were detected for all the mice.Results The single rhubarb ethanol extract ,single curcuma ethanol extract ,compatibility application of two drugs had hypolipidemic effects,as compared with those in control group and model group ( P <0.05).Conclusion The single rhubarb ethanol extract , single curcuma ethanol extract, compatibility application of two drugs can reduce blood fat levels in experimental mice with hyperlipidemia,moreover,the hypolipidemic effect of compatibility application of two drugs (1∶1)is superior to that of single drug extract.
