CAJ | 학술논문

目的比较不同时期在常规体外受精（IVF）受精失败病例施行补救卵胞浆内单精子注射（ICSI）的受精情况以探讨补救ICSI的最佳时机。方法将本院进行常规IVF失败的88例患者随机分为早期补救组与晚期补救组，早期补救组患者在常规IVF后4～8h实行补救ICSI，而晚期补救组在常规IVF后20～22h施行补救ICSI，比较两组患者正常受精率、卵裂率、可移植胚胎率、优质胚胎率与妊娠率。结果早期补救组正常受精率、卵裂率、可移植胚胎率、优质胚胎率与妊娠率分别为53.4%、93.8%、46.9%、38.5%、31.8%，晚期补救组则为46.1%、82.8%、32.1%、23.8%、6.8%，早期补救组上述指标均显著优于晚期补救组（P＜0.05）。结论对于常规IVF失败后患者应早期施行补救ICSI进行再受精，能够显著改善常规IVF失败患者的结局。
목적비교불동시기재상규체외수정（IVF）수정실패병례시행보구란포장내단정자주사（ICSI）적수정정황이탐토보구ICSI적최가시궤。방법장본원진행상규IVF실패적88례환자수궤분위조기보구조여만기보구조，조기보구조환자재상규IVF후4～8h실행보구ICSI，이만기보구조재상규IVF후20～22h시행보구ICSI，비교량조환자정상수정솔、란렬솔、가이식배태솔、우질배태솔여임신솔。결과조기보구조정상수정솔、란렬솔、가이식배태솔、우질배태솔여임신솔분별위53.4%、93.8%、46.9%、38.5%、31.8%，만기보구조칙위46.1%、82.8%、32.1%、23.8%、6.8%，조기보구조상술지표균현저우우만기보구조（P＜0.05）。결론대우상규IVF실패후환자응조기시행보구ICSI진행재수정，능구현저개선상규IVF실패환자적결국。
Objective To compare the effect of remedial intracytoplasmic sperm injection(ICSI)in different periods for conventional in vitro fertilization (IVF) fertilization failure cases in order to explore the best time for remedial ICSI. Methods 88 patients of routine IVF failure in our hospital were randomly divided into early remedial group and late remedial group, early remedial group of patients were given remedial ICSI 4-8h after the conventional IVF, while late remedial group were given remedy ICSI 20-22h after IVF. two groups were compared normal in normal fertilization rate, cleavage rate, embryo transplant rate, high quality embryo rate and pregnancy rate. Results Normal fertilization rate, cleavage rate, embryo transplant rate, high quality embryo rate and pregnancy rate of early remedial group were 53.4%, 93.8%, 46.9%, 38.5%, 31.8%,while those of late remedial group were 46.1 %, 82.8% , 32.1%, 23.8%, 6.8%. These indicators of early remedial group were significantly better than the late remedial group (P <0.05). Conclusion For patients of failure of conventional IVF remedy, they should be implemented early re-ICSI fertilization, which can significantly improve the outcome of patients who failed conventional IVF.