CAJ | 학술논문

目的探讨右美托咪啶对鼻内镜手术患者气管拔管期应激反应的影响。方法选择ASAⅠ～Ⅱ级择期鼻内镜手术患者60例，随机分为右美托咪啶组（D组）和对照组（C组），各30例。D组在麻醉诱导后给予右美托咪啶0.5μg/kg泵注，于10 min输注完毕。C组泵注15 mL生理盐水。记录两组诱导前（T 1）、注药后10 min(T 2)、苏醒时（T 3）、拔管即刻（T 4）、拔管后5 min（T 5）各时点的MAP及HR变化情况，记录苏醒时间、拔管时间及苏醒期躁动发生率。结果 D组围拔管期的MAP、HR显著低于C组，差异有统计学意义（P＜0.05）。D组的苏醒期躁动发生率低于对照组（P＜0.05）。两组苏醒时间及拔管时间比较，无统计学意义（P＞0.05）。结论在鼻内镜手术患者中应用右美托咪啶，减少围拔管期心血管反应及苏醒期躁动的发生率，而不延长苏醒及拔管时间。
목적탐토우미탁미정대비내경수술환자기관발관기응격반응적영향。방법선택ASAⅠ～Ⅱ급택기비내경수술환자60례，수궤분위우미탁미정조（D조）화대조조（C조），각30례。D조재마취유도후급여우미탁미정0.5μg/kg빙주，우10 min수주완필。C조빙주15 mL생리염수。기록량조유도전（T 1）、주약후10 min(T 2)、소성시（T 3）、발관즉각（T 4）、발관후5 min（T 5）각시점적MAP급HR변화정황，기록소성시간、발관시간급소성기조동발생솔。결과 D조위발관기적MAP、HR현저저우C조，차이유통계학의의（P＜0.05）。D조적소성기조동발생솔저우대조조（P＜0.05）。량조소성시간급발관시간비교，무통계학의의（P＞0.05）。결론재비내경수술환자중응용우미탁미정，감소위발관기심혈관반응급소성기조동적발생솔，이불연장소성급발관시간。
Objective To observe the effects of Dexmedetomidine on extubation response in patients undergoing endoscopic nasal surgery. Methods Sixty ASAⅠ-Ⅱpatients undergoing nasal endoscopic surgery were enrolled in this study,patients were randomly divided into Dexmedetomidine group (group D) and control group (group C).After induction,patients in Group D were subject to intravenous infusion Dexmedetomidine 0.5 ug/kg diluted to 15 mL via micropumps in 15 minutes,and group C received 15 mL normal saline infusion.Mean arterial pressure(MAP) and heart rate(HR) were recorded before induction (T 1),10 minutes after the injection (T 2),recovery time (T 3),extubation (T 4), 5 min after extubation (T 5).The recovery time and extubation time were recorded. Emergence agitation was observed. Results During peri-extubation period,MAP and HR in Group D were signiifcantly lower than that in Group C. The time to awkening and tracheal extubation were in different between the two groups.Less agitation was observed in Group D than Group C. Conclusion In patients undergoing endoscopic nasal surgery,Dexmedetomidine can effectively reduce cardiovascular response during extubation and the incidence of emergence agitation,but does not prolong the recovery and extubation time.