当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
28期
1-3
,共3页
结直肠癌%NGF%TrkA%P75%免疫组化
結直腸癌%NGF%TrkA%P75%免疫組化
결직장암%NGF%TrkA%P75%면역조화
Colorectal adenocarcinoma%Never growth factor%TrkA%P 75%Immunohistochemistry
目的探讨神经生长因子NGF及其受体TrkA和P 75在结直肠癌中的表达及其与临床病理学指标间的关系。方法运用免疫组化技术SABC法检测NGF、TrkA和P 75在80例结直肠癌和16例结直肠癌旁正常组织中的分布和表达情况。结果 NGF在结直肠癌组织中表达的阳性率57.5%，在癌旁正常组织中表达的阳性率25%；TrkA在结直肠癌组织中表达的阳性率55%，在癌旁正常组织中表达的阳性率31.3%；P 75在结直肠癌组织中表达的阳性率47.5%，在癌旁正常组织中表达的阳性率62.5%；NGF及TrkA在结直肠癌组织中的表达较癌旁正常结直肠组织高，而P 75的表达无显著差异。NGF和TrkA的表达与结直肠癌细胞分级、临床分期、淋巴结转移有关。P 75只与淋巴结转移有关。结论 NGF、TrkA和P 75与结直肠癌的淋巴结转移有关，NGF和TrkA两者在结直肠癌的细胞分化、浸润及淋巴结转移中有协同作用。
目的探討神經生長因子NGF及其受體TrkA和P 75在結直腸癌中的錶達及其與臨床病理學指標間的關繫。方法運用免疫組化技術SABC法檢測NGF、TrkA和P 75在80例結直腸癌和16例結直腸癌徬正常組織中的分佈和錶達情況。結果 NGF在結直腸癌組織中錶達的暘性率57.5%，在癌徬正常組織中錶達的暘性率25%；TrkA在結直腸癌組織中錶達的暘性率55%，在癌徬正常組織中錶達的暘性率31.3%；P 75在結直腸癌組織中錶達的暘性率47.5%，在癌徬正常組織中錶達的暘性率62.5%；NGF及TrkA在結直腸癌組織中的錶達較癌徬正常結直腸組織高，而P 75的錶達無顯著差異。NGF和TrkA的錶達與結直腸癌細胞分級、臨床分期、淋巴結轉移有關。P 75隻與淋巴結轉移有關。結論 NGF、TrkA和P 75與結直腸癌的淋巴結轉移有關，NGF和TrkA兩者在結直腸癌的細胞分化、浸潤及淋巴結轉移中有協同作用。
목적탐토신경생장인자NGF급기수체TrkA화P 75재결직장암중적표체급기여림상병이학지표간적관계。방법운용면역조화기술SABC법검측NGF、TrkA화P 75재80례결직장암화16례결직장암방정상조직중적분포화표체정황。결과 NGF재결직장암조직중표체적양성솔57.5%，재암방정상조직중표체적양성솔25%；TrkA재결직장암조직중표체적양성솔55%，재암방정상조직중표체적양성솔31.3%；P 75재결직장암조직중표체적양성솔47.5%，재암방정상조직중표체적양성솔62.5%；NGF급TrkA재결직장암조직중적표체교암방정상결직장조직고，이P 75적표체무현저차이。NGF화TrkA적표체여결직장암세포분급、림상분기、림파결전이유관。P 75지여림파결전이유관。결론 NGF、TrkA화P 75여결직장암적림파결전이유관，NGF화TrkA량자재결직장암적세포분화、침윤급림파결전이중유협동작용。
Objective To investigate the expression of never growth factor, its receptor TrkA and P 75 in human colorectal adenocarcinoma, and to evaluate the association between the expression and clinicopathological variables of colorectal adenocarcinoma. Methods With SABC immunohistochemistry to detect the expression of NGF、TrkA and P 75 in 80 colorectal adenocarcinoma and 16 normal colorectum, the relationship between the expression and clinical-pathological indices was also investigated. Results The positive rates of NGF in colorectal cancer and in colorectum were 57.5%and 25%.The positive rates of TrkA in colorectal cancer and in colorectum were 55%and 31.3%.The positive rates of P 75 in colorectal cancer and in colorectum were 47.5%and 62.5%.The expressions of NGF and TrkA in human colorectal adenocarcinoma were higher than that in the normal colorectum. The expression of P 75 had no signiifcant change in the two groups . The expression of NGF and TrkA were positively correlated with tumor stage and cell-type classiifcation and lymphatic invasion. the expression of P 75 was correlated with lymphatic invasion. Conclusion NGF、TrkA and P 75 participate in the progress of colorectal adenocarcinoma. NGF and TrkA had closely relationship with the differentiation. tumor stage and lymphatic invasion of the colorectal adenocarcinoma , and the roles might synergetic.
