CAJ | 학술논문

目的：探讨阿奇霉素对支原体肺炎患儿白细胞介素2（IL-2）、可溶性白细胞介素2受体（sIL-2R）及白细胞介素17（IL-17）水平的影响。方法将未感染肺炎患儿设为对照组（30例），支原体感染肺炎患者设为实验组（23例）。采用酶联免疫吸附试验（ELISA）检测两组治疗前后血清中IL-2、sIL-2R及IL-17水平。结果对照组血清IL-2水平为（8．51±0．23）pg/mL ，实验组血清IL-2水平为（15．72±0．58）pg/mL ，二者比较差异有统计学意义（P＜0．05）；对照组sIL-2R水平为（24．51±6．23）pg/mL ，实验组sIL-2R水平为（57．72±9．58）pg/mL ，二者比较差异有统计学意义（P＜0．05）；对照组IL-17水平为（4．51±0．23）pg/mL ，实验组IL-17水平为（7．72±0．58）pg/mL ，二者比较差异有统计学意义（P＜0．05）。治疗后实验组IL-2、sIL-2R及IL-17水平与治疗前比较，差异有统计学意义（P＜0．05）。结论 IL-2及IL-17与支原体肺炎发病机制有关，阿奇霉素可降低支原体肺炎患儿血清中IL-2、sIL-2R及IL-17的水平。
목적：탐토아기매소대지원체폐염환인백세포개소2（IL-2）、가용성백세포개소2수체（sIL-2R）급백세포개소17（IL-17）수평적영향。방법장미감염폐염환인설위대조조（30례），지원체감염폐염환자설위실험조（23례）。채용매련면역흡부시험（ELISA）검측량조치료전후혈청중IL-2、sIL-2R급IL-17수평。결과대조조혈청IL-2수평위（8．51±0．23）pg/mL ，실험조혈청IL-2수평위（15．72±0．58）pg/mL ，이자비교차이유통계학의의（P＜0．05）；대조조sIL-2R수평위（24．51±6．23）pg/mL ，실험조sIL-2R수평위（57．72±9．58）pg/mL ，이자비교차이유통계학의의（P＜0．05）；대조조IL-17수평위（4．51±0．23）pg/mL ，실험조IL-17수평위（7．72±0．58）pg/mL ，이자비교차이유통계학의의（P＜0．05）。치료후실험조IL-2、sIL-2R급IL-17수평여치료전비교，차이유통계학의의（P＜0．05）。결론 IL-2급IL-17여지원체폐염발병궤제유관，아기매소가강저지원체폐염환인혈청중IL-2、sIL-2R급IL-17적수평。
Objective To investigate effects of azithromycin on expression of interleukin 2 (IL-2) and soluble interleukin-2 re-ceptor (sIL-2R) and interleukin 17 (IL-17) in children with mycoplasma pneumonia .Methods 30 cases uninfected with pneumonia was control group and 23 cases with mycoplasma pneumoniae infection was test group .By enzyme-linked immunosorbent assay (ELISA) was used to detect serum IL-2 ,sIL-2R and IL-17 levels before and after treatment .Results The serum level of IL-2 was (8 .51 ± 0 .23) pg/mL in control group ,and the serum level of IL-2 was(15 .72 ± 0 .58)pg/mL in test group .There was significant difference between the two groups(P<0 .05) .The serum level of sIL-2R was (24 .51 ± 6 .23) pg/mL in control group ,and the ser-um level of sIL-2R was (57 .72 ± 9 .58)pg/mL in test group .There was significant difference between the two groups (P<0 .05) . The serum level of IL-17 was (4 .51 ± 0 .23) pg/mL ,and the serum level of IL-17 was(7 .72 ± 0 .58)pg/mL in test group .There was significant difference between the two groups(P<0 .05) .After treatment ,the serum levels of IL-2 ,sIL-2R and IL-17 were lower in test group (P<0 .05) .Conclusion IL-2 and IL-17 are related to mycoplasma pneumoniae pathogenesis ,and azithromycin can re-duce IL-2 ,sIL-2R and IL-17 levels .