CAJ | 학술논문

背景：将神经干细胞移植到脑梗死病灶区可以促进受损神经细胞的修复。目的：分析神经干细胞移植治疗脑梗死的相关影响因素。 　　方法：文章通过数据库检索的方式分析近年来关于神经干细胞移植治疗脑梗死的实验研究，从中国临床试验注册和基础实验研究两方面分析神经干细胞与脑梗死的研究进展。 　　结果与结论：脑梗死后神经干细胞的增殖和分化与脑内微环境密切相关，梗死区域有大量的神经细胞丢失。细胞因子在神经干细胞移植修复神经功能损伤时发挥一定作用，能够诱导大鼠脑梗死后神经干细胞的增殖、分化和迁移，目前被证实的有表皮生长因子、脑源性神经营养因子、胰岛素样生长因子1、神经生长因子、碱性成纤维细胞生长因子等。针灸和中医药对脑梗死后室管膜下区神经干细胞的增殖、迁移和分化有促进作用。神经干细胞移植治疗脑梗死的研究已经取得了阶段性进展，未来仍有许多问题需要进一步解决。
배경：장신경간세포이식도뇌경사병조구가이촉진수손신경세포적수복。목적：분석신경간세포이식치료뇌경사적상관영향인소。 　　방법：문장통과수거고검색적방식분석근년래관우신경간세포이식치료뇌경사적실험연구，종중국림상시험주책화기출실험연구량방면분석신경간세포여뇌경사적연구진전。 　　결과여결론：뇌경사후신경간세포적증식화분화여뇌내미배경밀절상관，경사구역유대량적신경세포주실。세포인자재신경간세포이식수복신경공능손상시발휘일정작용，능구유도대서뇌경사후신경간세포적증식、분화화천이，목전피증실적유표피생장인자、뇌원성신경영양인자、이도소양생장인자1、신경생장인자、감성성섬유세포생장인자등。침구화중의약대뇌경사후실관막하구신경간세포적증식、천이화분화유촉진작용。신경간세포이식치료뇌경사적연구이경취득료계단성진전，미래잉유허다문제수요진일보해결。
BACKGROUND:Neural stem cells transplanted into the infarct region can promote the recovery of damaged nerve cells after cerebral infarction. OBJECTIVE:To analyze the relevant influential factors of neural stem celltransplantation in the treatment of cerebral infarction. METHODS:In this paper, we analyzed the experimental studies concerning neural stem celltransplantation for cerebral infarction published in recent years based on database search. There were main two aspects for discussing the progress in neural stem cells and cerebral infarction, the Chinese clinical trial registration and basic experimental studies. RESULTS AND CONCLUSION:After cerebral infarction, neural stem cellproliferation and differentiation is closely related to the brain microenvironment. Large amount of nerve cellloss can be found in the infarct region. Cytokines can play a role in the neural stem celltransplantation to repair neurological injury after cerebral infarction, and also can induce neural stem cellproliferation, differentiation and migration, including epidermal growth factor, brain-derived neurotrophic factor, insulin-like growth factor 1, nerve growth factor, and basic fibroblast growth factor. Acupuncture and traditional Chinese medicine can promote the proliferation, migration and differentiation neural stem cells in the subependymal zone after cerebral infarction. Neural stem celltransplantation in the treatment of cerebral infarction has yielded progress, but there are stil many issues that need to be resolved in the future.