CAJ | 학술논문

背景：目前已有研究证明骨髓间充质干细胞移植治疗糖尿病足能够获得良好的效果。 　　目的：评价骨髓间充质干细胞移植治疗糖尿病足溃疡的效果以及血管内皮生长因子的表达情况。 　　方法：应用文献检索的方法获取骨髓间充质干细胞移植治疗糖尿病足及血管内皮生长因子表达的相关研究文献，对符合研究标准的文献进行深入的数据分析，文章选取骨髓间充质干细胞移植治疗糖尿病足的实验研究和临床应用进行分析，实验研究中，建立大鼠糖尿病足溃疡模型，给予骨髓间充质干细胞移植治疗，观察创面溃疡的愈合情况，并分析血管内皮生长因子的表达情况。临床应用研究中，对应用骨髓间充质干细胞移植治疗糖尿病足的患者进行观察随访，观察创面溃疡的愈合情况以及不良反应发生情况。 　　结果与结论：实验研究显示骨髓间充质干细胞移植治疗糖尿病足创面溃疡的愈合快于常规治疗，但是与正常足溃疡愈合相比仍较慢，且移植治疗后血管内皮生长因子的表达升高，但是低于正常足溃疡对照的水平。临床应用研究显示糖尿病足溃疡患者经骨髓间充质干细胞移植治疗后，创面溃疡基本均可完全愈合，且无心、脑血管疾病、肝肾功能损伤以及出凝血时间改变等不良反应发生。
배경：목전이유연구증명골수간충질간세포이식치료당뇨병족능구획득량호적효과。 　　목적：평개골수간충질간세포이식치료당뇨병족궤양적효과이급혈관내피생장인자적표체정황。 　　방법：응용문헌검색적방법획취골수간충질간세포이식치료당뇨병족급혈관내피생장인자표체적상관연구문헌，대부합연구표준적문헌진행심입적수거분석，문장선취골수간충질간세포이식치료당뇨병족적실험연구화림상응용진행분석，실험연구중，건립대서당뇨병족궤양모형，급여골수간충질간세포이식치료，관찰창면궤양적유합정황，병분석혈관내피생장인자적표체정황。림상응용연구중，대응용골수간충질간세포이식치료당뇨병족적환자진행관찰수방，관찰창면궤양적유합정황이급불량반응발생정황。 　　결과여결론：실험연구현시골수간충질간세포이식치료당뇨병족창면궤양적유합쾌우상규치료，단시여정상족궤양유합상비잉교만，차이식치료후혈관내피생장인자적표체승고，단시저우정상족궤양대조적수평。림상응용연구현시당뇨병족궤양환자경골수간충질간세포이식치료후，창면궤양기본균가완전유합，차무심、뇌혈관질병、간신공능손상이급출응혈시간개변등불량반응발생。
BACKGROUND:Bone marrow mesenchymal stem celltransplantation has been confirmed to have excellent effect on the treatment of diabetic foot. OBJECTIVE:To assess the therapeutic effect of bone marrow mesenchymal stem celltransplantation on diabetic foot ulcers and the expression of vascular endothelial growth factor. METHODS:Literatures concerning the effect of bone marrow mesenchymal stem celltransplantation on foot diabetic and expression of vascular endothelial stem cells were retrieved. Articles that met the criteria were analyzed in depth. Here, we analyzed the experimental research and clinical application of bone marrow mesenchymal stem cells in the treatment of diabetic foot. In experimental studies, rat models of diabetic foot ulcers were established and subjected to bone marrow mesenchymal stem celltransplantation to observe wound healing of ulcers and analyze the expression of vascular endothelial growth factor. In clinical research, the fol ow-up was conducted in diabetic foot patients undergoing bone marrow mesenchymal stem celltransplantation to observe the wound healing of ulcers and adverse reactions. RESULTS AND CONCLUSION: Experimental studies have shown that bone marrow mesenchymal stem celltransplantation is better than conventional treatment in the treatment of diabetic foot ulcers, but the healing of diabetic foot ulcers is stil slower than that of normal ulcers. After celltransplantation, the expression of vascular endothelial stem cells is elevated but stil lower than that in the normal ulcer controls. Clinical studies have shown that for patients with diabetic foot ulcers, the ulcer wound can be healed after bone marrow mesenchymal stem celltransplantation, as wel as there are no cardiovascular and cerebrovascular diseases, liver and kidney damage and changes in bleeding and coagulation time.