CAJ | 학술논문

背景：将具有特定功能的蛋白质、酶、多肽等生物活性物质固定于种植体表面，可促进骨潜能细胞及成骨细胞的增殖、分化，达到良好的成骨作用。 　　目的：介绍生物活性多肽精氨酸-甘氨酸-天冬氨酸的生物学特性，及其在骨质疏松状态下对细胞生物学行为和种植体骨整合的影响。 　　方法：计算机检索PubMed数据库(1984年1月至2013年1月)、万方数据(2002年1月至2012年12月)、CHKD期刊全文数据库(2002年1月至2012年12月)中，有关生物活性多肽精氨酸-甘氨酸-天冬氨酸的生物学特性，以及其在骨质疏松状态下对细胞生物学行为和种植体骨整合影响的文献。 　　结果与结论：在种植体表面接种生物活性物质可进一步改善种植体与骨组织的整合速度。通过在生物材料表面固定精氨酸-甘氨酸-天冬氨酸多肽的方法进行仿生态化学修饰，模拟体内细胞外基质环境，促进细胞黏附和生长，是早期改善内植物骨整合的有效途径，也是近年组织工程领域研究的重要方向。今后研究的重点在于设计特异高效的多肽和简单有效的固定方法，同时将对这类物质长期应用的安全性做进一步深入的研究。
배경：장구유특정공능적단백질、매、다태등생물활성물질고정우충식체표면，가촉진골잠능세포급성골세포적증식、분화，체도량호적성골작용。 　　목적：개소생물활성다태정안산-감안산-천동안산적생물학특성，급기재골질소송상태하대세포생물학행위화충식체골정합적영향。 　　방법：계산궤검색PubMed수거고(1984년1월지2013년1월)、만방수거(2002년1월지2012년12월)、CHKD기간전문수거고(2002년1월지2012년12월)중，유관생물활성다태정안산-감안산-천동안산적생물학특성，이급기재골질소송상태하대세포생물학행위화충식체골정합영향적문헌。 　　결과여결론：재충식체표면접충생물활성물질가진일보개선충식체여골조직적정합속도。통과재생물재료표면고정정안산-감안산-천동안산다태적방법진행방생태화학수식，모의체내세포외기질배경，촉진세포점부화생장，시조기개선내식물골정합적유효도경，야시근년조직공정영역연구적중요방향。금후연구적중점재우설계특이고효적다태화간단유효적고정방법，동시장대저류물질장기응용적안전성주진일보심입적연구。
BACKGROUND:The biological substances fixed onto the implant surface, including specific proteins, enzymes, polypeptides, could promote the proliferation and differentiation of osteogenic cells in order to achieve a good osteogenic effect. OBJECTIVE:To introduce the biological characteristics of the arginine-glycine-aspartic acid (RGD) peptides, cellbiological behavior and implant osseointegration in osteoporosis. METHODS:Authors retrieved the relevant articles in PubMed database (January 1984 to January 2013), Wanfang database (January 2002 to December 2012) and CHKD database (January 2002 to December 2012) using the key words“RGD peptides, osteoporosis, bone marrow mesenchymal stem cells, osseointegration, osteoblast, induced differentiation”. Papers were included concerning the biological characteristics of RGD peptides, the biological behavior of cells and the bone-implant integration in osteoporosis. RESULTS AND CONCLUSION:Osseointegration on the surface between implant and bone tissue can be further improved by grafting biological y active substance. Bionics modification, to simulate the extracellular matrix environment in vivo, can promote celladhesion and growth, which is an effective way to improve osseointegration and is also an important direction of research in the field of tissue engineering recently. The future research is focused on designing specific and efficient polypeptides and simple and effective fixation methods.