CAJ | 학술논문

背景：器官移植后细菌感染及并发症的发生是个重要而复杂的问题，移植后的监护处理可以提高患者手术的成功率。目的：通过CNKI数据库，汤森路透Web of Science数据库以及北美临床试验注册中心进行相关检索，对器官移植后重症监护处理相关文献进行文献计量学及临床试验注册项目分析。方法：①使用关键词“重症监护”，“移植”在CNKI数据库检索，得到文献138篇，经阅读标题和进行初筛，排除因研究目的与文章无关的文献，重复研究及不典型报道115篇，共保存23篇文献做进一步分析。②使用关键词“intensive care”，“transplantation”在汤森路透Web of Science数据库对器官移植后重症监护处理相关文献进行检索，时间范围2008至2013年。③使用关键词“intensive care”和“transplantation”，在北美临床试验注册中心进行临床试验项目检索，得到的注册项目有50项，其中干预性研究项目仅有10项。结果与结论：①近年来，中国器官移植后的重症监护相关文献总体呈逐渐上升的趋势。与国际上器官移植后的重症监护研究文献相比，国内对此领域的研究关注相对较少，文章数量和质量还有待提高。②2008至2013年在汤森路透Web of Science数据库中关于器官移植后的重症监护已发表文献多达1693篇。美国发文量最多，532篇，占总数比重最大，为31.424%。Transplantation Proceeding(《移植学会会刊》杂志)发表文献最多，144篇，占全部文献数量的8.506%。③北美临床试验注册中心注册的器官移植后重症监护相关临床试验注册项目共有50项，干预性研究所占比重最大，其次为观察性研究，诊断性研究暂时还没有相关注册项目。2008至2013年干预性研究的注册项目仅有10项。器官移植手术复杂、创伤大，移植后早期的监测和护理直接关系到手术的成败。移植后早期加强对患者生命体征、排斥反应、细菌感染等方面的监测和护理，可减少并发症的发生，提高患者生存率和生活质量。揹景：器官移植後細菌感染及併髮癥的髮生是箇重要而複雜的問題，移植後的鑑護處理可以提高患者手術的成功率。目的：通過CNKI數據庫，湯森路透Web of Science數據庫以及北美臨床試驗註冊中心進行相關檢索，對器官移植後重癥鑑護處理相關文獻進行文獻計量學及臨床試驗註冊項目分析。方法：①使用關鍵詞“重癥鑑護”，“移植”在CNKI數據庫檢索，得到文獻138篇，經閱讀標題和進行初篩，排除因研究目的與文章無關的文獻，重複研究及不典型報道115篇，共保存23篇文獻做進一步分析。②使用關鍵詞“intensive care”，“transplantation”在湯森路透Web of Science數據庫對器官移植後重癥鑑護處理相關文獻進行檢索，時間範圍2008至2013年。③使用關鍵詞“intensive care”和“transplantation”，在北美臨床試驗註冊中心進行臨床試驗項目檢索，得到的註冊項目有50項，其中榦預性研究項目僅有10項。結果與結論：①近年來，中國器官移植後的重癥鑑護相關文獻總體呈逐漸上升的趨勢。與國際上器官移植後的重癥鑑護研究文獻相比，國內對此領域的研究關註相對較少，文章數量和質量還有待提高。②2008至2013年在湯森路透Web of Science數據庫中關于器官移植後的重癥鑑護已髮錶文獻多達1693篇。美國髮文量最多，532篇，佔總數比重最大，為31.424%。Transplantation Proceeding(《移植學會會刊》雜誌)髮錶文獻最多，144篇，佔全部文獻數量的8.506%。③北美臨床試驗註冊中心註冊的器官移植後重癥鑑護相關臨床試驗註冊項目共有50項，榦預性研究所佔比重最大，其次為觀察性研究，診斷性研究暫時還沒有相關註冊項目。2008至2013年榦預性研究的註冊項目僅有10項。器官移植手術複雜、創傷大，移植後早期的鑑測和護理直接關繫到手術的成敗。移植後早期加彊對患者生命體徵、排斥反應、細菌感染等方麵的鑑測和護理，可減少併髮癥的髮生，提高患者生存率和生活質量。
배경：기관이식후세균감염급병발증적발생시개중요이복잡적문제，이식후적감호처리가이제고환자수술적성공솔。목적：통과CNKI수거고，탕삼로투Web of Science수거고이급북미림상시험주책중심진행상관검색，대기관이식후중증감호처리상관문헌진행문헌계량학급림상시험주책항목분석。방법：①사용관건사“중증감호”，“이식”재CNKI수거고검색，득도문헌138편，경열독표제화진행초사，배제인연구목적여문장무관적문헌，중복연구급불전형보도115편，공보존23편문헌주진일보분석。②사용관건사“intensive care”，“transplantation”재탕삼로투Web of Science수거고대기관이식후중증감호처리상관문헌진행검색，시간범위2008지2013년。③사용관건사“intensive care”화“transplantation”，재북미림상시험주책중심진행림상시험항목검색，득도적주책항목유50항，기중간예성연구항목부유10항。결과여결론：①근년래，중국기관이식후적중증감호상관문헌총체정축점상승적추세。여국제상기관이식후적중증감호연구문헌상비，국내대차영역적연구관주상대교소，문장수량화질량환유대제고。②2008지2013년재탕삼로투Web of Science수거고중관우기관이식후적중증감호이발표문헌다체1693편。미국발문량최다，532편，점총수비중최대，위31.424%。Transplantation Proceeding(《이식학회회간》잡지)발표문헌최다，144편，점전부문헌수량적8.506%。③북미림상시험주책중심주책적기관이식후중증감호상관림상시험주책항목공유50항，간예성연구소점비중최대，기차위관찰성연구，진단성연구잠시환몰유상관주책항목。2008지2013년간예성연구적주책항목부유10항。기관이식수술복잡、창상대，이식후조기적감측화호리직접관계도수술적성패。이식후조기가강대환자생명체정、배척반응、세균감염등방면적감측화호리，가감소병발증적발생，제고환자생존솔화생활질량。
BACKGROUND:It is an important and complex issue for the incidence of bacterial infection and complications after transplantation. The monitoring and care after transplantation can improve the success rate of transplantation. OBJECTIVE:To search the database of China National Knowledge Infrastructure, North American Clinical Trial Register and Thomson Reuters Web of Science database, and to perform literature metrological analysis and clinical trials registration project analysis on the published literatures of the monitoring and care after transplantation. METHODS:A total of 138 literatures were searched with the key words of“intensive care, transplantation”in the database of China National Knowledge Infrastructure on the intensive care after transplantation. 23 literatures were used for further analysis by reading titles and abstracts and 115 papers were excluded; the Thomson Reuters Web of Science database was searched with the key words of“intensive care, transplantation”for the literatures on the intensive care after transplantation published from 2008 to 2013;the North American Clinical Trial Register was searched with the key words of“intensive care, transplantation”for the related clinical trials, and a total of 50 registered projects were obtained, only 10 interventional studies. RESUTLS AND CONCLUSION:In recent years, the literatures on the intensive care after transplantation show a gradual increase trend. Compared with international research, fewer researches in this field emerge in China, literature quantity and quality need to be improved. There have been 1 693 papers published in the Thomson Reuters Web of Science database regarding the intensive care after transplantation. United States published the most literatures than other countries, total 532 papers, accounting for the largest proportion, 31.424%of total literatures. Transplantation Proceeding published the most literatures, total 144 papers, accounting for 8.506%of total literatures. There are 50 clinical trial registration projects related to the intensive care after transplantation in the North American Clinical Trial Register, 10 of them were interventional study, accounting for the majority, fol owed by observational study. Diagnostic study had no related registration projects. The surgery of transplantation was complex with trauma. The early monitoring and care post-transplantation are directly related to the success of surgery. Strengthening the monitoring and care of patients’ vital signs, rejection, bacterial infections and other aspects can reduce the complications and improve patients survival rate and quality of life.