CAJ | 학술논문

背景：应用实验动物模型可深入探讨超声及超声造影在缺血型胆道病变诊治方面的作用。但尚未见适用于各种肝胆疾病兔模型的超声造影研究的时相划分标准。目的：探讨正常兔胆道系统常规超声、超声造影表现及兔肝脏超声造影时相划分标准。方法：对10只正常新西兰兔行肝胆系统常规超声检查，并对常规超声可显示的胆管壁行超声造影检查，总结其特点。结果与结论：①门脉管径/胆管管径为3.59±0.54。②常规超声及超声造影上胆总管及中叶胆管的显示率显著高于外叶胆管，胆总管-中叶胆管是兔首选的超声观察目标。③正常兔肝脏超声造影时相兔肝脏增强时相划分与人类不同，可划分为动脉期(10-20 s)、门脉期(21-30 s)及延迟期(31-180 s)。正常胆管壁动脉期呈高增强，门脉期及延迟期呈等增强。上述正常参数的建立，为进一步研究超声造影在兔胆道缺血诊治方面的作用奠定基础，亦可推广应用至兔的其他肝胆疾病模型。
배경：응용실험동물모형가심입탐토초성급초성조영재결혈형담도병변진치방면적작용。단상미견괄용우각충간담질병토모형적초성조영연구적시상화분표준。목적：탐토정상토담도계통상규초성、초성조영표현급토간장초성조영시상화분표준。방법：대10지정상신서란토행간담계통상규초성검사，병대상규초성가현시적담관벽행초성조영검사，총결기특점。결과여결론：①문맥관경/담관관경위3.59±0.54。②상규초성급초성조영상담총관급중협담관적현시솔현저고우외협담관，담총관-중협담관시토수선적초성관찰목표。③정상토간장초성조영시상토간장증강시상화분여인류불동，가화분위동맥기(10-20 s)、문맥기(21-30 s)급연지기(31-180 s)。정상담관벽동맥기정고증강，문맥기급연지기정등증강。상술정상삼수적건립，위진일보연구초성조영재토담도결혈진치방면적작용전정기출，역가추엄응용지토적기타간담질병모형。
BACKGROUND:The experimental animal models can be used to in-depth investigate the effect of ultrasound and contrast-enhanced ultrasound in the diagnosis and treatment of ischemic biliary lesions. But there is no report on the phase timing standard of rabbit model contrast-enhanced ultrasound that used in various hepatobiliary diseases. OBJECTIVE:To investigate the ultrasonic appearance of normal rabbit biliary ducts with conventional ultrasonography and contrast-enhanced ultrasonography, and the criterion of contrast-enhanced ultrasonography phase timing of rabbit liver. METHODS:The conventional ultrasonography of hepatobiliary system was performed on 10 healthy New Zealand rabbits, and contrast-enhanced ultrasonography was performed on duct wal s that displayed in conventional ultrasonography, then the features were analyzed. RESULTS AND CONCLUSION:(1) The bile duct of normal New Zealand rabbits showed a portal to biliary caliber ratio of 3.59±0.54. (2) The detection rates of common and middle lobe bile ducts were significantly higher than that of lateral lobe bile ducts on both conventional ultrasonography and contrast-enhanced ultrasonography. (3) The phases of contrast-enhanced ultrasonography of normal rabbit liver were divided into arterial phase (10-20 seconds), portal phase (21-30 seconds) and late phase (31-180 seconds). The normal duct wal presented hyper-enhancing at arterial phase and persistent iso-enhancing at portal and late phases. The establishment of these parameters of normal New Zealand rabbits not only lays a foundation for the application of contrast-enhanced ultrasonography on biliary ischemia but also expands to other hepatobiliary models.