CAJ | 학술논문

背景：目前应用的各种软骨修复方法均有其优点和不足，修复组织多以纤维软骨为主，缺乏正常透明软骨的组织化学特性和生物力学特性。目的：探讨生物型异种骨软骨移植修复关节软骨损伤的可行性。方法：实验动物普通山羊随机分成两组，实验组供体为猪膝关节，以Smith & Nephew骨软骨移植器械，取直径4.5 mm、长10 mm的圆柱状骨软骨条，应用专利技术对动物骨软骨进行去抗原，对照组供体为羊膝关节骨软骨条，以低温冷冻法保存。分别于股骨滑车及内侧髁负重面的损伤处作骨软骨植入，术后16，32周处死动物，进行大体形态及病理切片观察。结果与结论：大体观察实验组部分软骨缺损移植处有纤维样的组织覆盖；部分移植物原表面软骨发黄，表面与周缘软骨有明显界限；对照组大体及切片镜下观察软骨缺损区基本被移植软骨覆盖，移植边缘可见裂隙。结果可见生物型异种骨软骨移植修复关节软骨损伤的作用与同种异体骨软骨比较有差别，同种异体骨软骨移植修复效果更佳。
배경：목전응용적각충연골수복방법균유기우점화불족，수복조직다이섬유연골위주，결핍정상투명연골적조직화학특성화생물역학특성。목적：탐토생물형이충골연골이식수복관절연골손상적가행성。방법：실험동물보통산양수궤분성량조，실험조공체위저슬관절，이Smith & Nephew골연골이식기계，취직경4.5 mm、장10 mm적원주상골연골조，응용전리기술대동물골연골진행거항원，대조조공체위양슬관절골연골조，이저온냉동법보존。분별우고골활차급내측과부중면적손상처작골연골식입，술후16，32주처사동물，진행대체형태급병리절편관찰。결과여결론：대체관찰실험조부분연골결손이식처유섬유양적조직복개；부분이식물원표면연골발황，표면여주연연골유명현계한；대조조대체급절편경하관찰연골결손구기본피이식연골복개，이식변연가견렬극。결과가견생물형이충골연골이식수복관절연골손상적작용여동충이체골연골비교유차별，동충이체골연골이식수복효과경가。
BACKGROUND:The methods used to repair articular cartilage defects currently have the cons and pros. Fibrocartilages are commonly used to repair tissues, and the fibrocartilage lacks of the tissue biomechanical properties and chemical properties of normal hyaline cartilage. OBJECTIVE:To investigate the feasibility of biological osteochondral xenogenic graft transplantation to repair articular cartilage defects. METHODS:The normal goats were randomly divided into two groups. The donor pig knee joints were the experimental group. Cylindrical osteochondral with the diameter of 4.5 mm and length of 10 mm were col ected with the Smith&Nephew osteochondral transplantation device, and the patented technology was used for deantigen. The donor goat knee joint osteochondrals were the control group and preserved with cryopreservation. The lesions on femoral trochlea and weight-bearing surface of medial condyle were selected respectively for osteochondral implantation, and the animals were sacrificed at 16 and 32 weeks after operation for the general and pathological section observation. RESULTS AND CONCLUSION:General observation in the experimental showed that the lesions were covered by fibroid tissue;some cartilage of the grafts turned yel ow and there was clear boundary between the surface and the peripheral cartilages;the general and section observation under microscope showed that lesions of the control group were covered by the grafts basical y, and cracks could be seen on the edge of the transplant part. The results show that there is difference between effects of biological osteochondral xenogenic graft transplantation and osteochondral al ograft transplantation for the repairing of articular cartilage defects, and osteochondral al ograft transplantation bas better effect.