中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
44期
7709-7714
,共6页
刘明娟%刘丽辉%施兵%叶丽萍%张永清
劉明娟%劉麗輝%施兵%葉麗萍%張永清
류명연%류려휘%시병%협려평%장영청
器官移植%肝移植%急性髓系白血病%免疫抑制%弥散性血管内凝血%肝功能%骨髓细胞形态学%柔红霉素%阿糖胞苷%米托蒽醌
器官移植%肝移植%急性髓繫白血病%免疫抑製%瀰散性血管內凝血%肝功能%骨髓細胞形態學%柔紅黴素%阿糖胞苷%米託蒽醌
기관이식%간이식%급성수계백혈병%면역억제%미산성혈관내응혈%간공능%골수세포형태학%유홍매소%아당포감%미탁은곤
liver transplantation%leukemia,myeloid%immunosuppressive agents%disseminated intravascular coagulation
背景:肝移植后急性髓系白血病是一种极少见但病死率极高的并发症。目的:分析肝移植后急性髓系白血病的临床特征。方法:报告1例肝移植后发生急性早幼粒细胞性白血病病例,并辅以文献复习。结果与结论:患者接受原位肝移植后85个月,拔牙后出血不止,进一步查凝血功能异常、血常规、骨髓细胞学、白血病免疫分型检查提示为急性早幼粒细胞白血病、PML/RARa融合基因阳性,明确诊断急性早幼粒细胞性白血病,合并弥散性血管内凝血,给予输注新鲜冰冻血浆纠正凝血异常,经维甲酸、亚砷酸、柔红霉素联合诱导化疗,骨髓完全缓解。予柔红霉素和阿糖胞苷,米托蒽醌和阿糖胞苷巩固化疗2个疗程,之后定期予亚砷酸化疗,骨髓持续缓解。化疗同时,调整免疫抑制剂剂量和类型,患者肝功能稳定,未发生严重感染等并发症。结果说明,肝移植后可并发急性髓系白血病,以急性早幼粒细胞白血病常见,肝移植患者出现血象、凝血异常,要考虑急性早幼粒细胞白血病可能。应早期诊断及治疗,以减少死亡率。
揹景:肝移植後急性髓繫白血病是一種極少見但病死率極高的併髮癥。目的:分析肝移植後急性髓繫白血病的臨床特徵。方法:報告1例肝移植後髮生急性早幼粒細胞性白血病病例,併輔以文獻複習。結果與結論:患者接受原位肝移植後85箇月,拔牙後齣血不止,進一步查凝血功能異常、血常規、骨髓細胞學、白血病免疫分型檢查提示為急性早幼粒細胞白血病、PML/RARa融閤基因暘性,明確診斷急性早幼粒細胞性白血病,閤併瀰散性血管內凝血,給予輸註新鮮冰凍血漿糾正凝血異常,經維甲痠、亞砷痠、柔紅黴素聯閤誘導化療,骨髓完全緩解。予柔紅黴素和阿糖胞苷,米託蒽醌和阿糖胞苷鞏固化療2箇療程,之後定期予亞砷痠化療,骨髓持續緩解。化療同時,調整免疫抑製劑劑量和類型,患者肝功能穩定,未髮生嚴重感染等併髮癥。結果說明,肝移植後可併髮急性髓繫白血病,以急性早幼粒細胞白血病常見,肝移植患者齣現血象、凝血異常,要攷慮急性早幼粒細胞白血病可能。應早期診斷及治療,以減少死亡率。
배경:간이식후급성수계백혈병시일충겁소견단병사솔겁고적병발증。목적:분석간이식후급성수계백혈병적림상특정。방법:보고1례간이식후발생급성조유립세포성백혈병병례,병보이문헌복습。결과여결론:환자접수원위간이식후85개월,발아후출혈불지,진일보사응혈공능이상、혈상규、골수세포학、백혈병면역분형검사제시위급성조유립세포백혈병、PML/RARa융합기인양성,명학진단급성조유립세포성백혈병,합병미산성혈관내응혈,급여수주신선빙동혈장규정응혈이상,경유갑산、아신산、유홍매소연합유도화료,골수완전완해。여유홍매소화아당포감,미탁은곤화아당포감공고화료2개료정,지후정기여아신산화료,골수지속완해。화료동시,조정면역억제제제량화류형,환자간공능은정,미발생엄중감염등병발증。결과설명,간이식후가병발급성수계백혈병,이급성조유립세포백혈병상견,간이식환자출현혈상、응혈이상,요고필급성조유립세포백혈병가능。응조기진단급치료,이감소사망솔。
BACKGROUND:Acute myeloid leukemia after liver transplantation is a rare complication with high mortality. OBJECTIVE:To study the clinical features of acute myeloid leukemia after liver transplantation. METHODS:One case of acute promyelocytic leukemia after liver transplantation was reported, and literatures were reviewed. RESULTS AND CONCLUSION:Case presentation was post-odontectomy bleeding with associative abnormal coagulation test at 85 months after liver transplantation. Routine blood test, bone marrow test and chromosome analysis and examination diagnosed as acute promyelocytic leukemia and promyelocytic leukemia/RARαpositive chimeric gene, and clearly diagnosed as acute promyelocytic leukemia combined with disseminated intravascular coagulation. The patient received fresh frozen plasma transfusion to correct the abnormal coagulation, and then received induction chemotherapy with retinoic acid, arsenic trioxide and daunorubicin to obtain bone marrow complete remission. The patient was treated with daunorubicin combined with cytarabine and mitoxantrone combined with cytarabine regimens after remission induction to consolidate the chemotherapy for two courses of treatment, and then subsequently subjected to arsenous acid chemotherapy, and the bone marrow was sustained for remission. During chemotherapy, the dose and type of immunosuppressive agents were adjusted, and the patient had stable liver function without serious infection or complications. The results indicate that acute myeloid leukemia is common and often occurs after liver transplantation. When the patient displays hematological abnormality, acute promyelocytic leukemia should be considered. Early diagnosis and treatment can reduce the mortality.