中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
44期
7687-7692
,共6页
器官移植%肾移植%前列地尔%肾功能恢复延迟%肾血流阻力指数%急性排斥反应%血肌酐%肌酐清除率
器官移植%腎移植%前列地爾%腎功能恢複延遲%腎血流阻力指數%急性排斥反應%血肌酐%肌酐清除率
기관이식%신이식%전렬지이%신공능회복연지%신혈류조력지수%급성배척반응%혈기항%기항청제솔
kidney transplantation%alprostadil%graft rejection%delayed graft function
背景：研究发现前列地尔具有抑制血小板凝集、松弛血管平滑肌、舒张外周小血管进而改善末梢循环的作用。目的：进一步验证前列地尔能否促进肾移植后移植肾功能早期恢复。方法：对125例加用前列地尔组患者肾移植后2周内每天静脉滴注前列地尔20μg，与同期内115例未用前列地尔组进行对比，比较两组患者肾移植后7d尿量、血肌酐、肌酐清除率；彩超检测移植肾血流阻力指数以及两组肾功能恢复延迟和肾移植后3个月内急性排斥反应的发生率。结果与结论：加用前列地尔组的患者肾移植后尿量和肌酐清除率均明显大于未用前列地尔组；血肌酐浓度、移植肾血流阻力指数亦明显低于未用前列地尔组；加用前列地尔组移植肾功能延迟恢复发生率为7.2%，显著低于未用前列地尔组13.9%(P<0.01)；两组急性排斥反应发生率差异无显著性意义。提示肾移植患者早期使用前列地尔能够促进肾功能的早期恢复，对肾移植后早期康复具有促进作用。
揹景：研究髮現前列地爾具有抑製血小闆凝集、鬆弛血管平滑肌、舒張外週小血管進而改善末梢循環的作用。目的：進一步驗證前列地爾能否促進腎移植後移植腎功能早期恢複。方法：對125例加用前列地爾組患者腎移植後2週內每天靜脈滴註前列地爾20μg，與同期內115例未用前列地爾組進行對比，比較兩組患者腎移植後7d尿量、血肌酐、肌酐清除率；綵超檢測移植腎血流阻力指數以及兩組腎功能恢複延遲和腎移植後3箇月內急性排斥反應的髮生率。結果與結論：加用前列地爾組的患者腎移植後尿量和肌酐清除率均明顯大于未用前列地爾組；血肌酐濃度、移植腎血流阻力指數亦明顯低于未用前列地爾組；加用前列地爾組移植腎功能延遲恢複髮生率為7.2%，顯著低于未用前列地爾組13.9%(P<0.01)；兩組急性排斥反應髮生率差異無顯著性意義。提示腎移植患者早期使用前列地爾能夠促進腎功能的早期恢複，對腎移植後早期康複具有促進作用。
배경：연구발현전렬지이구유억제혈소판응집、송이혈관평활기、서장외주소혈관진이개선말소순배적작용。목적：진일보험증전렬지이능부촉진신이식후이식신공능조기회복。방법：대125례가용전렬지이조환자신이식후2주내매천정맥적주전렬지이20μg，여동기내115례미용전렬지이조진행대비，비교량조환자신이식후7d뇨량、혈기항、기항청제솔；채초검측이식신혈류조력지수이급량조신공능회복연지화신이식후3개월내급성배척반응적발생솔。결과여결론：가용전렬지이조적환자신이식후뇨량화기항청제솔균명현대우미용전렬지이조；혈기항농도、이식신혈류조력지수역명현저우미용전렬지이조；가용전렬지이조이식신공능연지회복발생솔위7.2%，현저저우미용전렬지이조13.9%(P<0.01)；량조급성배척반응발생솔차이무현저성의의。제시신이식환자조기사용전렬지이능구촉진신공능적조기회복，대신이식후조기강복구유촉진작용。
BACKGROUND:Studies have found that alprostadil can inhibit platelet aggregation, relax vascular smooth muscle, diastole peripheral blood vessels and thereby improving peripheral circulation. OBJECTIVE:To further verify whether alprostadil can promote the early recovery of renal function of renal transplantation recipients. METHODS:Total y 125 patients in the alprostadil group received intravenous infusion of 20μg alprostadil daily, and then compared with the 115 patients in the unused alprostadil group in the same time. The urine volume, serum creatinine and the creatinine clearance were compared between two groups;blood flow resistance-indexes, as wel as the incidences of delay recovery of renal function and acute rejection were detected under color doppler ultrasound. RESULTS AND CONCLUSION:The urine volume and creatinine clearance in the alprostadil group were significantly higher than those in the unused alprostadil group;while the serum creatinine and the blood flow resistance-indexes were lower than the unused alprostadil group. The incidence of delay recovery of renal function in the alprostadil group was 7.2%which was significantly lower than that in the unused alprostadil group (P<0.01);there was no significant difference in the incidence of acute rejection between two groups. The findings suggest that the administration of alprostadil in renal transplantation recipients during the early stage of kidney transplantation can accelerate the recovery of the renal function and can promote the early rehabilitation after renal transplantation.
