中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
4期
137-139
,共3页
雷公藤多苷%香丹注射液%联合治疗%小儿过敏性紫癜性肾炎%凝血机制%临床效果
雷公籐多苷%香丹註射液%聯閤治療%小兒過敏性紫癜性腎炎%凝血機製%臨床效果
뢰공등다감%향단주사액%연합치료%소인과민성자전성신염%응혈궤제%림상효과
tripterygium glycosides%Xiangdan injection%combination therapy%HSPN%clotting mechanism%clinical efficacy
目的:探讨雷公藤多苷联合香丹注射液治疗小儿过敏性紫癜性肾炎(henoch schonlein purpura nephritis,HSPN)的疗效观察及凝血机制的影响。方法将本组76例小儿过敏性紫癜性肾炎患者按照随机数字表法将其随机分为对照组和观察组(n=38)。对照组给予香丹注射液治疗,治疗组在对照组治疗基础上服用雷公藤多苷。2组治疗均以12周为一个疗程。结果治疗组治疗后总有效率(94.74%)显著高于对照组(68.42%),且具有显著性差异(P<0.05);2组治疗前凝血酶原时间(prothrombin time, PT)、纤维蛋白原(fibrinogen ,FIB)、活化部分凝血活酶时间(activated partial thromboplastin time,APPT)、血小板(blood platelet,PLT)水平比较无显著性差异;对照组治疗后FIB、PLT水平显著低于治疗前(P<0.05),治疗前后PT、APPT不存在统计学显著性差异;治疗组治疗后FIB、PLT水平显著低于治疗前(P<0.05),治疗后较治疗前PT水平显著升高(P<0.05),APPT水平治疗前后无差异。治疗后治疗组PT水平显著高于对照组(P<0.05),治疗组PLT水平显著低于对照组(P<0.05),在FIB、APPT水平上2组不存在统计学差异。2组患者治疗后均未出现明显不良反应。结论雷公藤多苷联合香丹注射液治疗小儿过敏性紫癜性肾炎疗效显著,影响患儿凝血机制,改善PT、FIB、PLT水平,安全可靠。
目的:探討雷公籐多苷聯閤香丹註射液治療小兒過敏性紫癜性腎炎(henoch schonlein purpura nephritis,HSPN)的療效觀察及凝血機製的影響。方法將本組76例小兒過敏性紫癜性腎炎患者按照隨機數字錶法將其隨機分為對照組和觀察組(n=38)。對照組給予香丹註射液治療,治療組在對照組治療基礎上服用雷公籐多苷。2組治療均以12週為一箇療程。結果治療組治療後總有效率(94.74%)顯著高于對照組(68.42%),且具有顯著性差異(P<0.05);2組治療前凝血酶原時間(prothrombin time, PT)、纖維蛋白原(fibrinogen ,FIB)、活化部分凝血活酶時間(activated partial thromboplastin time,APPT)、血小闆(blood platelet,PLT)水平比較無顯著性差異;對照組治療後FIB、PLT水平顯著低于治療前(P<0.05),治療前後PT、APPT不存在統計學顯著性差異;治療組治療後FIB、PLT水平顯著低于治療前(P<0.05),治療後較治療前PT水平顯著升高(P<0.05),APPT水平治療前後無差異。治療後治療組PT水平顯著高于對照組(P<0.05),治療組PLT水平顯著低于對照組(P<0.05),在FIB、APPT水平上2組不存在統計學差異。2組患者治療後均未齣現明顯不良反應。結論雷公籐多苷聯閤香丹註射液治療小兒過敏性紫癜性腎炎療效顯著,影響患兒凝血機製,改善PT、FIB、PLT水平,安全可靠。
목적:탐토뢰공등다감연합향단주사액치료소인과민성자전성신염(henoch schonlein purpura nephritis,HSPN)적료효관찰급응혈궤제적영향。방법장본조76례소인과민성자전성신염환자안조수궤수자표법장기수궤분위대조조화관찰조(n=38)。대조조급여향단주사액치료,치료조재대조조치료기출상복용뢰공등다감。2조치료균이12주위일개료정。결과치료조치료후총유효솔(94.74%)현저고우대조조(68.42%),차구유현저성차이(P<0.05);2조치료전응혈매원시간(prothrombin time, PT)、섬유단백원(fibrinogen ,FIB)、활화부분응혈활매시간(activated partial thromboplastin time,APPT)、혈소판(blood platelet,PLT)수평비교무현저성차이;대조조치료후FIB、PLT수평현저저우치료전(P<0.05),치료전후PT、APPT불존재통계학현저성차이;치료조치료후FIB、PLT수평현저저우치료전(P<0.05),치료후교치료전PT수평현저승고(P<0.05),APPT수평치료전후무차이。치료후치료조PT수평현저고우대조조(P<0.05),치료조PLT수평현저저우대조조(P<0.05),재FIB、APPT수평상2조불존재통계학차이。2조환자치료후균미출현명현불량반응。결론뢰공등다감연합향단주사액치료소인과민성자전성신염료효현저,영향환인응혈궤제,개선PT、FIB、PLT수평,안전가고。
Objective To observe effects of tripterygium glycosides combined with Xiangdan injection in henoch schonlein purpura nephritis (HSPN)and influence of the clotting mechanism,providing reference for clinical diagnosis and treatment.Methods 76 cases of children with allergic purpura nephritis were randomly divided into control group(n=38)and observation group(n=38)according to the random number table.Control group was given Xiangdan injection treatment.Observation group was given Xiangdan injection treatment combined with tripterygium glycoside.12 weeks was considered as a course of treatment. Results After treatment,the total efficiency rate in treatment group(94.74%)was significantly higher than control group(68.42%),which was statistically different(P <0.05).Before treatment,prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APPT),platelet(PLT)levels were not significantly different between two groups;FIB and PLT levels in the control group were significantly lower than before treatment(P<0.05 ),PT and APPT had no statistically significant difference before and after treatment.After treatment in observation group,FIB and PLT levels were significantly lower than before treatment(P<0.05 ),PT level was significantly higher compared with before treatment(P<0.05 ),APTT level had no difference before and after treatment.After treatment,PT in treatment group was significantly higher than the control group(P<0.05 ),PLT in treatment group were significantly lower than the control group (P <0.05 ),FIB and APTT had no statistical difference.There was no adverse reaction in two groups after treatment.Conclusion Tripterygium glycosides combined with Xiangdan injection treatment for HSPN has significant effect,which affect the children clotting mechanism to improve the PT,FIB,PLT levels.It is safe and valuable in clinical research.