CAJ | 학술논문

目的：探讨西洛他唑对骨折创伤术后下肢静脉栓塞患者血浆中血小板相关指标的影响。方法选择2012年2月～2013年7月就诊于莱芜市人民医院的104例骨折创伤术后下肢静脉栓塞患者为研究对象，随机分为A、B 2组，每组52例。2组均给予常规护理，A组加用西洛他唑，B组加用阿司匹林选取同期来本院进行体检的50例健康人员作为对照（C组）。分析各组患者血浆中血小板相关指标的变化。结果治疗前A、B 2组血浆中IL-6和IL-8均显著高于C组（P＜0.01），治疗后，2组IL-6和IL-8水平均显著降低（P＜0.01），但2组组间比较差异无统计学意义。治疗前A、B 2组血浆中CRP、FIB和D-D含量均显著高于C组（P＜0.01， P＜0.05），治疗后2组CRP、FIB和D-D含量均显著降低（P＜0.01，P＜0.05），A组CRP较B组含量更低，差异有统计学意义（P＜0.05），A组FIB和D-D含量与B组无差异。治疗前A、B两组PDW、PLT、MPV和P-LCR含量均显著高于C组（P＜0.01，P＜0.05），治疗后2组PDW、PLT、MPV和P-LCR均显著降低（P＜0.01，P＜0.05），但2组组间比较差异无统计学意义。治疗前A、B 2组血小板活化率均显著高于C组（P＜0.01），治疗后，2组血小板活化率均显著降低（P＜0.01），但2组间比较差异无统计学意义。结论西洛他唑可通过降低炎性因子的表达、降低D-二聚体和纤维蛋白原的水平以及通过影响血小板相关指标降低血小板的活化，从而发挥抗血栓作用。
목적：탐토서락타서대골절창상술후하지정맥전새환자혈장중혈소판상관지표적영향。방법선택2012년2월～2013년7월취진우래무시인민의원적104례골절창상술후하지정맥전새환자위연구대상，수궤분위A、B 2조，매조52례。2조균급여상규호리，A조가용서락타서，B조가용아사필림선취동기래본원진행체검적50례건강인원작위대조（C조）。분석각조환자혈장중혈소판상관지표적변화。결과치료전A、B 2조혈장중IL-6화IL-8균현저고우C조（P＜0.01），치료후，2조IL-6화IL-8수평균현저강저（P＜0.01），단2조조간비교차이무통계학의의。치료전A、B 2조혈장중CRP、FIB화D-D함량균현저고우C조（P＜0.01， P＜0.05），치료후2조CRP、FIB화D-D함량균현저강저（P＜0.01，P＜0.05），A조CRP교B조함량경저，차이유통계학의의（P＜0.05），A조FIB화D-D함량여B조무차이。치료전A、B량조PDW、PLT、MPV화P-LCR함량균현저고우C조（P＜0.01，P＜0.05），치료후2조PDW、PLT、MPV화P-LCR균현저강저（P＜0.01，P＜0.05），단2조조간비교차이무통계학의의。치료전A、B 2조혈소판활화솔균현저고우C조（P＜0.01），치료후，2조혈소판활화솔균현저강저（P＜0.01），단2조간비교차이무통계학의의。결론서락타서가통과강저염성인자적표체、강저D-이취체화섬유단백원적수평이급통과영향혈소판상관지표강저혈소판적활화，종이발휘항혈전작용。
Objective To evaluate the effects of cilostazol on plasma platelet-related indicators in trauma fractures patients with postoperative venous thrombosis.Methods 104 cases of trauma fractures patients with postoperative venous thrombosis from February 2012 to July 2013 in Laiwu City People’s Hospital were collected and randomly divided into group A and group group B,each had 52 cases Two groups were given conventional nursing, and group A were added cilostaeol group B were added aspirin.Other 50 cases of current healthy people for medical examination were selected for controls (group C).The effects of cilostazol on plasma platelet-related indicators in each treatment group were analyzed. Result Before treatment,the levels of IL-6 and IL-8 in group A and B were significantly higher than group C(P<0.01),but there is no difference between group A and B.The plasma CRP, FIB and DD in group A and B were significantly decreased than group C(P<0.01,P<0.05).After appropriate treatment,the levels of CRP,FIB and DD in group A and B were significantly reduced than pre-treatment(P<0.01,P<0.05).CRP content in group A was lower than that in group B,the difference was statistically significant(P<0.05 ),FIB and DD in group A showed no differencewith group B.Before treatment,PDW,PLT,MPV and P-LCR in group A and B were significantly higher than group C(P<0.01,P<0.05).After appropriate treatment,the levels of PDW,PLT,MPV and P-LCR in two groups were significantly decreased (P <0.01,P <0.05 ),but there was no difference between two groups.Before treatment,the expression of platelet activation in group A,B were significantly higher than group C(P<0.01),but significantly reduced after appropriate treatment (P<0.01),and the difference between the two groups was not statistically significant.Conclusion Cilostazol could reduce the expression of inflammatory factors,levels of D-dimer and fibrinogen and platelet related indicators by reduced platelet activation,which plays antithrombotic effect.