CAJ | 학술논문

目的：探讨缬沙坦联合叶酸治疗老年高血压肾病的治疗效果和作用机制。方法选取潍坊市人民医院收治的120例原发性高血压伴肾衰竭患者作为临床研究对象，以单双号分组的方式分为2组。观察组（n＝60）患者联合应用缬沙坦和叶酸进行治疗，对照组（n＝60）患者单一应用缬沙坦进行治疗。2组患者治疗4周后评价治疗效果，测量2组患者治疗前后的收缩压、舒张压、血肌酐、尿素氮和24 h尿蛋白定量。结果观察组患者治疗后的收缩压和舒张压显著优于对照组，差异具有统计学意义（P＜0.01），血肌酐、尿素氮和24 h尿蛋白定量检查结果均优于对照组，差异具有统计学意义（P＜0.05）。观察组患者总有效率优于对照组（P＜0.05），观察组患者的显效率显著优于对照组（P＜0.01）。结论联合应用缬沙坦和叶酸治疗老年高血压肾病患者总有效率高，同时显著降低血压、血肌酐、尿素氮和24 h尿蛋白定量。
목적：탐토힐사탄연합협산치료노년고혈압신병적치료효과화작용궤제。방법선취유방시인민의원수치적120례원발성고혈압반신쇠갈환자작위림상연구대상，이단쌍호분조적방식분위2조。관찰조（n＝60）환자연합응용힐사탄화협산진행치료，대조조（n＝60）환자단일응용힐사탄진행치료。2조환자치료4주후평개치료효과，측량2조환자치료전후적수축압、서장압、혈기항、뇨소담화24 h뇨단백정량。결과관찰조환자치료후적수축압화서장압현저우우대조조，차이구유통계학의의（P＜0.01），혈기항、뇨소담화24 h뇨단백정량검사결과균우우대조조，차이구유통계학의의（P＜0.05）。관찰조환자총유효솔우우대조조（P＜0.05），관찰조환자적현효솔현저우우대조조（P＜0.01）。결론연합응용힐사탄화협산치료노년고혈압신병환자총유효솔고，동시현저강저혈압、혈기항、뇨소담화24 h뇨단백정량。
Objective To investigate the clinical efficacy of vallarta combined with folic acid in treatment of elderly hypertensive nephropathy.Methods 120 patients of essential hypertension with renal failure in Weifang People’s Hospital were divided into control group and observation group according to the odd and even numbers.The observation group was given vallarta and folic acid,the control group were given vallarta.4 weeks later,the effect of two groups were evaluated.Systolic and diastolic blood pressure,serum cretonne,blood urea nitrogen and 24h urinary protein were measured before and after treatment. Results The patients after treatment systolic and diastolic pressure was significantly better than control group, the difference was statistically significant(P<0.05),serum creatinine,blood urea nitrogen and 24h urine protein test results were better than control group,the difference was statistically significance(P<0.05).The total effective rate of observation group was better than control group(P<0.05),the obvious effective rate of observation group was significantly better than control group(P<0.01).Conclusion Combination of valsartan and folic acid in treatment of elderly hypertensive nephropathy has a higher total effective rate,while significantly lower blood pressure,serum creatinine,blood urea nitrogen and 24h urinary protein.