中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
4期
118-120
,共3页
哮喘%糖皮质激素%白细胞介素-18%白细胞介素-33
哮喘%糖皮質激素%白細胞介素-18%白細胞介素-33
효천%당피질격소%백세포개소-18%백세포개소-33
asthma%glucocorticoid%interleukin-18%interleukin-33
目的：探讨支气管哮喘发病机制中白细胞介素-18（interleukin-18，IL-18）及白细胞介素-33（interleukin-33，IL-33）的作用。方法选择2011年3月～2012年1月收治于武汉市第三医院的支气管哮喘急性发作期患者40例作为激素组，同期体检健康者30例作为对照组。测定对照组与激素组治疗前后血清中 IL-18、IL-33水平，1秒用力呼气容积（forced expiratory volume in one second，FEV1）与用力肺活量（forced vital capacity，FVC）的比值 FEV1％，检测嗜酸粒细胞（eosinophil cell，EOS）及免疫球蛋白 E （immunoglobulin E，IgE）的数量；观察激素组治疗前后血清中IL-18、IL-33水平变化，分析与FEV1％、EOS、IgE等的关联。结果治疗前激素组血清IL-18、IL-33水平显著高于对照组（P＜0.05），FEV1％、EOS和IgE与对照组差异显著（P＜0.05）；经糖皮质激素联合雾化治疗后激素组IL-18、IL-33显著低于治疗前（P＜0.05），FEV1％、EOS和IgE与治疗前相比改善显著（P＜0.05）；激素组治疗后IL-18、IL-33、FEV1％和IgE与对照组相比无显著性差异；根据皮尔森相关系数分析得出，IL-18与IgE呈正相关性，差异具有统计学意义（P＜0.05）；IL-33与EOS呈正相关性（P＜0.05）；IL-18、IL-33与FEV1％呈负相关性（P＜0.05）。结论支气管哮喘急性发作期中， IL-18和IL-33参与并促进炎性反应的发生。
目的：探討支氣管哮喘髮病機製中白細胞介素-18（interleukin-18，IL-18）及白細胞介素-33（interleukin-33，IL-33）的作用。方法選擇2011年3月～2012年1月收治于武漢市第三醫院的支氣管哮喘急性髮作期患者40例作為激素組，同期體檢健康者30例作為對照組。測定對照組與激素組治療前後血清中 IL-18、IL-33水平，1秒用力呼氣容積（forced expiratory volume in one second，FEV1）與用力肺活量（forced vital capacity，FVC）的比值 FEV1％，檢測嗜痠粒細胞（eosinophil cell，EOS）及免疫毬蛋白 E （immunoglobulin E，IgE）的數量；觀察激素組治療前後血清中IL-18、IL-33水平變化，分析與FEV1％、EOS、IgE等的關聯。結果治療前激素組血清IL-18、IL-33水平顯著高于對照組（P＜0.05），FEV1％、EOS和IgE與對照組差異顯著（P＜0.05）；經糖皮質激素聯閤霧化治療後激素組IL-18、IL-33顯著低于治療前（P＜0.05），FEV1％、EOS和IgE與治療前相比改善顯著（P＜0.05）；激素組治療後IL-18、IL-33、FEV1％和IgE與對照組相比無顯著性差異；根據皮爾森相關繫數分析得齣，IL-18與IgE呈正相關性，差異具有統計學意義（P＜0.05）；IL-33與EOS呈正相關性（P＜0.05）；IL-18、IL-33與FEV1％呈負相關性（P＜0.05）。結論支氣管哮喘急性髮作期中， IL-18和IL-33參與併促進炎性反應的髮生。
목적：탐토지기관효천발병궤제중백세포개소-18（interleukin-18，IL-18）급백세포개소-33（interleukin-33，IL-33）적작용。방법선택2011년3월～2012년1월수치우무한시제삼의원적지기관효천급성발작기환자40례작위격소조，동기체검건강자30례작위대조조。측정대조조여격소조치료전후혈청중 IL-18、IL-33수평，1초용력호기용적（forced expiratory volume in one second，FEV1）여용력폐활량（forced vital capacity，FVC）적비치 FEV1％，검측기산립세포（eosinophil cell，EOS）급면역구단백 E （immunoglobulin E，IgE）적수량；관찰격소조치료전후혈청중IL-18、IL-33수평변화，분석여FEV1％、EOS、IgE등적관련。결과치료전격소조혈청IL-18、IL-33수평현저고우대조조（P＜0.05），FEV1％、EOS화IgE여대조조차이현저（P＜0.05）；경당피질격소연합무화치료후격소조IL-18、IL-33현저저우치료전（P＜0.05），FEV1％、EOS화IgE여치료전상비개선현저（P＜0.05）；격소조치료후IL-18、IL-33、FEV1％화IgE여대조조상비무현저성차이；근거피이삼상관계수분석득출，IL-18여IgE정정상관성，차이구유통계학의의（P＜0.05）；IL-33여EOS정정상관성（P＜0.05）；IL-18、IL-33여FEV1％정부상관성（P＜0.05）。결론지기관효천급성발작기중， IL-18화IL-33삼여병촉진염성반응적발생。
Objective To investigate the role of interleukin-18 (IL-18 )and interleukin-33 (IL-33 )in the pathogenesis of bronchial asthma.Methods 40 cases with acute attack of bronchial asthma admitted in Wuhan Third Hospital from March 2011 to January 2012 were chosen as the hormone group,and 30 cases healthy people in the same period who underwent routine physical exa mination were chosen as control group.The serum levels of IL-18 and IL-33,the rate of forced expiratory volume in one second(FEV1 )and forced vitalcapacity(FVC,FEV1%),the number of eosinophil cells(EOS)and immunoglobulin E(IgE)were detected in control group and hormone group before and after treatment.Compare the serum levels of IL-18 and IL-33 in hormone group before and after treatment,and the relevance between IL-18,IL-33 and IgE,EOS and FEV1%. Results Compared with control group,the serum levels of IL-18 and IL-33 in hormone group pre-treatment were significantly increased(P<0.05),FEV1%,EOS and IgE had significant difference(P<0.05).Compared with hormone group pre-treatment the serum levels of IL-18 and IL-33 in hormone group post-treatment were significantly decreased(P<0.05),FEV1%,EOS and IgE improved significantly (P<0.05).Compared with control group,the serum levels of IL-18, IL-33,FEV1% and IgE in hormone group post-treatment had no significant difference.The pearson correlative analysis showed that there were positive correlations between the levels of IL-18,IL-33,IgE and EOS,respectively(P<0.05),and there were negative correlations between IL-18,IL-33 levels and FEV1%,respectively(P<0.05).Conclusion IL-18 and IL-33 participate in the acute asthma,and may play stimulation role in the inflammatory process of asthma.
