CAJ | 학술논문

目的：分析骨与关节化脓性感染的病原菌分布及耐药情况，为临床抗生素合理使用提供依据。方法对上饶市人民医院骨外科2009年1月～2013年6月收治514例骨与关节化脓性感染病例菌群分布及药敏试验进行回顾性分析。结果分离革兰阴性菌296株感染率为47.2％，以大肠埃希菌最常见，感染率为15.9％，其次以鲍曼不动杆菌、铜绿假单胞菌多见，感染率分别为11.8％、11.3％；分离革兰阳性菌331株，感染率为52.8％，以表皮葡萄球菌、金黄色葡萄球菌多见，感染率分别为21.5％、13.7％；革兰阴性菌对亚胺培南的敏感性最高，革兰阳性菌对万古霉素敏感。结论革兰阳性菌是骨与关节化脓性感染的主要致病菌，根据药敏试验选择抗生素对临床耐药菌株的治疗有重要的临床意义。
목적：분석골여관절화농성감염적병원균분포급내약정황，위림상항생소합리사용제공의거。방법대상요시인민의원골외과2009년1월～2013년6월수치514례골여관절화농성감염병례균군분포급약민시험진행회고성분석。결과분리혁란음성균296주감염솔위47.2％，이대장애희균최상견，감염솔위15.9％，기차이포만불동간균、동록가단포균다견，감염솔분별위11.8％、11.3％；분리혁란양성균331주，감염솔위52.8％，이표피포도구균、금황색포도구균다견，감염솔분별위21.5％、13.7％；혁란음성균대아알배남적민감성최고，혁란양성균대만고매소민감。결론혁란양성균시골여관절화농성감염적주요치병균，근거약민시험선택항생소대림상내약균주적치료유중요적림상의의。
Objective To evaluate the distribution of pathogens causing bone and joint purulent infections and the bacterial resistance to antibiotics,and to provide reference of clinical antibiotic therapy.Methods A total of 514 patients who had bone and joint purulent infections in Department of Orthopedics of Shangrao People’s Hospital from Jan 2009 to Jun 2013 were retrospectively analyzed. Results 296 strains of Gram-negative bacteria were isolated,the infection rate was 47.2%,among which 296 strains of Escherichia coli were the most common infection pathogen,the infection rate was 15.6%,followed by Acinetobacter baumannii,Pseudomonas aeruginosa,and the infection rates were 11.8%,11.3%.331 strains of Gram-positive bacteria were isolated,the infection rate was 52.8%.Staphylococcus epidermidis,Staphylococcus aureus,were the common infection pathogens,following the infection rates were 21.5%,13.7%.Gram-negative bacteria had the highest sensitivity to imipenem,while Gram-positive bacteria had sensitivity to vancomycin.Conclusion Gram-positive bacteria is the main pathogens with bone and joint purulent infections.Selection of antibiotics according to the drug sensitive test has important clinical significance.