中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
4期
85-87,90
,共4页
任更朴%房忠卫%刘淑会%王扬
任更樸%房忠衛%劉淑會%王颺
임경박%방충위%류숙회%왕양
PCI%围手术期%NT-PROBNP%cTn%急性冠脉综合征
PCI%圍手術期%NT-PROBNP%cTn%急性冠脈綜閤徵
PCI%위수술기%NT-PROBNP%cTn%급성관맥종합정
PCI%perioperative%NT-PROBNP%cTn%acute coronary syndrome
目的：探讨PCI围手术期血清N 末端脑钠肽前体（N-terminal pro-B-type natriuretic peptide，NT-PROBNP）和肌钙蛋白（cardiac troponin，cTn）联合检测在老年急性冠脉综合征（acute coronary syndrome，ACS）中的应用。方法选取2013年4月～2014年4月期间山东省聊城市第二人民医院收治的67例需行PCI治疗的老年ACS患者为研究对象，选取同期健康老人30例作为对照。检测并比较2组研究对象围手术期血清NT-PROBNP和cTn水平，分析血清NT-PROBNP和cTn与老年ACS患者心功能的关系，并采用ROC曲线分析血清NT-PROBNP和cTn联合检测对老年ACS患者心功能的预测能力。结果老年ACS患者血清cTnT、cTnI和NT-PROBNP水平均较健康老人显著升高（P＜0.05），术后4h、12h和24h老年ACS患者的血清cTnT、cTnI和NT-PROBNP水平均较术前升高，术后72h患者血清cTnT、cTnI和NT-PROBNP水平逐渐降至术前水平或更低，术后4h、12h和24h各时间点之间的血清cTnT、cTnI和NT-PROBNP水平比较差异均有统计学意义（P＜0.05）。Pearson相关性分析结果显示：血清cTnT、cTnI和NT-PROBNP水平与老年ACS患者心功能均呈负相关（rcTn C ＝-0.675，r cTnT ＝-0.706，rcTnI ＝-0.841，rNT-PROBNP ＝0.822，P＜0.05）。ROC曲线下面积可信区间0.678～0.945，0.6≤A≤0.9，提示血清NT-PROBNP和cTn联合检测对老年ACS患者心功能的预测价值良好。结论老年ACS患者血清NT-PROBNP和cTn水平与老年ACS患者患者心功能均呈负相关，血清NT-PROBNP和cTn联合检测可作为行PCI的老年ACS患者心功能的预测指标。
目的：探討PCI圍手術期血清N 末耑腦鈉肽前體（N-terminal pro-B-type natriuretic peptide，NT-PROBNP）和肌鈣蛋白（cardiac troponin，cTn）聯閤檢測在老年急性冠脈綜閤徵（acute coronary syndrome，ACS）中的應用。方法選取2013年4月～2014年4月期間山東省聊城市第二人民醫院收治的67例需行PCI治療的老年ACS患者為研究對象，選取同期健康老人30例作為對照。檢測併比較2組研究對象圍手術期血清NT-PROBNP和cTn水平，分析血清NT-PROBNP和cTn與老年ACS患者心功能的關繫，併採用ROC麯線分析血清NT-PROBNP和cTn聯閤檢測對老年ACS患者心功能的預測能力。結果老年ACS患者血清cTnT、cTnI和NT-PROBNP水平均較健康老人顯著升高（P＜0.05），術後4h、12h和24h老年ACS患者的血清cTnT、cTnI和NT-PROBNP水平均較術前升高，術後72h患者血清cTnT、cTnI和NT-PROBNP水平逐漸降至術前水平或更低，術後4h、12h和24h各時間點之間的血清cTnT、cTnI和NT-PROBNP水平比較差異均有統計學意義（P＜0.05）。Pearson相關性分析結果顯示：血清cTnT、cTnI和NT-PROBNP水平與老年ACS患者心功能均呈負相關（rcTn C ＝-0.675，r cTnT ＝-0.706，rcTnI ＝-0.841，rNT-PROBNP ＝0.822，P＜0.05）。ROC麯線下麵積可信區間0.678～0.945，0.6≤A≤0.9，提示血清NT-PROBNP和cTn聯閤檢測對老年ACS患者心功能的預測價值良好。結論老年ACS患者血清NT-PROBNP和cTn水平與老年ACS患者患者心功能均呈負相關，血清NT-PROBNP和cTn聯閤檢測可作為行PCI的老年ACS患者心功能的預測指標。
목적：탐토PCI위수술기혈청N 말단뇌납태전체（N-terminal pro-B-type natriuretic peptide，NT-PROBNP）화기개단백（cardiac troponin，cTn）연합검측재노년급성관맥종합정（acute coronary syndrome，ACS）중적응용。방법선취2013년4월～2014년4월기간산동성료성시제이인민의원수치적67례수행PCI치료적노년ACS환자위연구대상，선취동기건강노인30례작위대조。검측병비교2조연구대상위수술기혈청NT-PROBNP화cTn수평，분석혈청NT-PROBNP화cTn여노년ACS환자심공능적관계，병채용ROC곡선분석혈청NT-PROBNP화cTn연합검측대노년ACS환자심공능적예측능력。결과노년ACS환자혈청cTnT、cTnI화NT-PROBNP수평균교건강노인현저승고（P＜0.05），술후4h、12h화24h노년ACS환자적혈청cTnT、cTnI화NT-PROBNP수평균교술전승고，술후72h환자혈청cTnT、cTnI화NT-PROBNP수평축점강지술전수평혹경저，술후4h、12h화24h각시간점지간적혈청cTnT、cTnI화NT-PROBNP수평비교차이균유통계학의의（P＜0.05）。Pearson상관성분석결과현시：혈청cTnT、cTnI화NT-PROBNP수평여노년ACS환자심공능균정부상관（rcTn C ＝-0.675，r cTnT ＝-0.706，rcTnI ＝-0.841，rNT-PROBNP ＝0.822，P＜0.05）。ROC곡선하면적가신구간0.678～0.945，0.6≤A≤0.9，제시혈청NT-PROBNP화cTn연합검측대노년ACS환자심공능적예측개치량호。결론노년ACS환자혈청NT-PROBNP화cTn수평여노년ACS환자환자심공능균정부상관，혈청NT-PROBNP화cTn연합검측가작위행PCI적노년ACS환자심공능적예측지표。
Objective To investigate the application of serum NT-PROBNP and cTn level detection in senior acute coronary syndrome(ACS) patients during PCI perioperative.Methods 67 ACS patients who need PCI treatment in the Second People’s Hospital of Liaocheng from April 2013 to April 2014 were selected and their perioperative serum NT-PROBNP and cTn levels were detected.At the same time,30 healthy senior people were chosed as control and their serum NT-PROBNP and cTn levels were also detected.Perioperative serum NT-PROBNP and cTn levels between ACS patients and heathy people were compared,the relationship between serum NT-PROBNP,cTn level and cardiac function of ACS patients were analyzed,and the ROC curve was used to analyze the predictive value of serum NT-PROBNP and cTn joint detection on cardiac function in ACS patients. Results Serum cTnT,cTnI and NT-PROBNP levels of ACS patients were higher than that of healthy senior people (P<0.05 ).Serum cTnT,cTnI and NT-PROBNP levels of ACS patients in postoperative 4h,12h and 24h were higher than that of preoperative,and serum cTnT,cTnI and NT-PROBNP levels in postoperative 72 were lowered,and the differences were statistically significant(P<0.05 ).Pearson correlation analysis results showed that serum cTnT, cTnI and NT-PROBNP levels and heart function of senior ACS patients were negatively correlated (rcTnT=-0.706,rcTnI =-0.841,rNT-PROBNP =-0.822, P<0.05).Area under the ROC curve was 0.678 to 0.945,which belongs to 0.6 -0.9,serum NT-PROBNP and cTn joint detection could well predict the heart function of senior ACS patients.Conclusion Serum cTnT,cTnI and NT-PROBNP levels and heart function of senior ACS patients are negatively correlated.Serum NT-PROBNP and cTn joint detection can be used as predictor of cardiac function of senior ACS patients treated with PCI.
