中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
4期
79-80,84
,共3页
卵巢上皮性癌%多西他赛%奈达铂
卵巢上皮性癌%多西他賽%奈達鉑
란소상피성암%다서타새%내체박
epithelial ovarian cancer%docetaxel%nedaplatin
目的：观察多西他赛联合奈达铂（nedaplatin，NDP）方案对卵巢上皮性癌治疗的近期疗效和不良反应。方法选取2009年1月～2010年1月四川省什邡市人民医院收治的50例中晚期卵巢上皮性癌患者，随机分为治疗组和对照组，每组25例。治疗组采用多西他赛和奈达铂治疗，对照组给予卡铂。分析比较2组的近期疗效和不良反应。结果治疗组与对照组的近期总有效率分别为76.00％和52.00％，差异有统计学意义（P＜0.05）；治疗组白细胞减少发生率为36.00％，血小板减少发生率为24.00％，与对照组比较差异无统计学意义；治疗组恶心、呕吐、脱发反应发生率分别为12.00％、8.00％和44.00％，明显低于对照组（40％、28％和64％），2组比较差异有统计学意义（P＜0.05）；治疗组2年生存率为37.5％，对照组为28.00％，2组比较差异有统计学意义（P＜0.05）。结论多西他赛联合奈达铂是治疗中晚期卵巢癌的有效化疗方案。
目的：觀察多西他賽聯閤奈達鉑（nedaplatin，NDP）方案對卵巢上皮性癌治療的近期療效和不良反應。方法選取2009年1月～2010年1月四川省什邡市人民醫院收治的50例中晚期卵巢上皮性癌患者，隨機分為治療組和對照組，每組25例。治療組採用多西他賽和奈達鉑治療，對照組給予卡鉑。分析比較2組的近期療效和不良反應。結果治療組與對照組的近期總有效率分彆為76.00％和52.00％，差異有統計學意義（P＜0.05）；治療組白細胞減少髮生率為36.00％，血小闆減少髮生率為24.00％，與對照組比較差異無統計學意義；治療組噁心、嘔吐、脫髮反應髮生率分彆為12.00％、8.00％和44.00％，明顯低于對照組（40％、28％和64％），2組比較差異有統計學意義（P＜0.05）；治療組2年生存率為37.5％，對照組為28.00％，2組比較差異有統計學意義（P＜0.05）。結論多西他賽聯閤奈達鉑是治療中晚期卵巢癌的有效化療方案。
목적：관찰다서타새연합내체박（nedaplatin，NDP）방안대란소상피성암치료적근기료효화불량반응。방법선취2009년1월～2010년1월사천성십방시인민의원수치적50례중만기란소상피성암환자，수궤분위치료조화대조조，매조25례。치료조채용다서타새화내체박치료，대조조급여잡박。분석비교2조적근기료효화불량반응。결과치료조여대조조적근기총유효솔분별위76.00％화52.00％，차이유통계학의의（P＜0.05）；치료조백세포감소발생솔위36.00％，혈소판감소발생솔위24.00％，여대조조비교차이무통계학의의；치료조악심、구토、탈발반응발생솔분별위12.00％、8.00％화44.00％，명현저우대조조（40％、28％화64％），2조비교차이유통계학의의（P＜0.05）；치료조2년생존솔위37.5％，대조조위28.00％，2조비교차이유통계학의의（P＜0.05）。결론다서타새연합내체박시치료중만기란소암적유효화료방안。
Objective To observe the clinical efficacy of docetaxel and nedaplatin (NDP)in treatment of patients with epithelial ovarian cancer. Methods 50 cases with epithelial ovarian cancer collected in Shifang People’s Hospital from 2009 January to 2010 January were randomly divided into treatment group and control group,each had 25 cases.Treatment group were given docetaxel and nedaplatin,while control group were given carboplatin. The efficacy and adverse reactions in two groups were observed and compared.Results The recent efficacy in two groups were 76.00% and 52.00%, respectively,and the difference was significant (P <0.05 ).Compared with control group, the incidence of leucopenia was 36.00% and thrombocytopenia was 24.00% in treatment group,there was no significant difference between them.The incidences of nausea,vomiting and alopecia in treatment group were 12.00%,8.00% and 44.00%,which lower than that in control group (40%,28% and 64%),the differences between two groups were all significant(P<0.05 ).The two years survival rates in treatment group was 37.5%,and 28% in control group,there was no significant difference between two groups.Conclusion Docetaxel and nedaplatin has good clinical efficacy in treatment of epithelial ovarian cancer.
