CAJ | 학술논문

目的：探讨亚低温干预对急性辐射损伤小鼠的保护效果。方法40只雄性BALB/c小鼠随机分为4组，受照组均接受6 Gy γ射线单次全身照射，（亚低温＋照射）组在照射前给予亚低温干预（28℃～30℃），（照射＋亚低温）组照射后给予亚低温干预，动态观察各组小鼠体温、体重、外周血白细胞，照后28天解剖观察脏器与骨髓恢复情况。结果与单纯照射组相比，（亚低温＋照射）组外周血白细胞数恢复时间提前1周，胸腺重量和系数增大，且差异显著；（照射＋亚低温）组外周血白细胞数恢复时间提前4天。结论亚低温对6 Gy单次全身照射小鼠有一定的辐射损伤保护作用。
목적：탐토아저온간예대급성복사손상소서적보호효과。방법40지웅성BALB/c소서수궤분위4조，수조조균접수6 Gy γ사선단차전신조사，（아저온＋조사）조재조사전급여아저온간예（28℃～30℃），（조사＋아저온）조조사후급여아저온간예，동태관찰각조소서체온、체중、외주혈백세포，조후28천해부관찰장기여골수회복정황。결과여단순조사조상비，（아저온＋조사）조외주혈백세포수회복시간제전1주，흉선중량화계수증대，차차이현저；（조사＋아저온）조외주혈백세포수회복시간제전4천。결론아저온대6 Gy단차전신조사소서유일정적복사손상보호작용。
This paper is to investigate the effect of mild hypothermia on acute radiation syndrome in mice . Forty male BALB/c mice were randomly are divided into 4 groups .The mice were exposed to gamma ray at 6 . 0 Gy ,0 .92 Gy/min ,the mice in mild hypothermia+radiation group were received mild hypothermia treatment before irradiation and radiation + mild hypothermia group after irradiation . The descend range of pripheral blood leukocyte number in mild hypothermia + radiation group was 1 week in advance to restore ;Thymus weight and coefficient increased ,the ratio of PCE/(PCE+NCE ) was lower than radiation group .The descend range of pripheral blood leukocyte number in radiation +mild hypothermia group was lower than radiation group on the first day after irradiation ,and 4 days in advance to restore .The descend range of pripheral blood leuko-cyte number in mice treated by mild hypothermia either before or after irradiation decreased lower in early time after irradiation and recovery earlier ,Mild hypothermia had some protective effect on mice radiated at 6 Gy .