全科医学临床与教育
全科醫學臨床與教育
전과의학림상여교육
CLINICAL EDUCATION OF GENERAL PRACTICE
2014年
4期
389-391,404
,共4页
徐裕%曾德志%胡伟明%樊学文
徐裕%曾德誌%鬍偉明%樊學文
서유%증덕지%호위명%번학문
酒精所致精神障碍%氨磺必利%疗效%安全性
酒精所緻精神障礙%氨磺必利%療效%安全性
주정소치정신장애%안광필리%료효%안전성
mental disorder induced by alcohol%amisupiride%efficacy%safety
目的:比较氨磺必利与奋乃静治疗酒精所致精神障碍(MDIA)的临床疗效与安全性。方法将100例MDIA患者随机分成研究组和对照组,每组50例,分别使用氨磺必利与奋乃静治疗8周,用阳性与阴性综合征量表(PANSS)评定临床疗效,观察不良反应。结果在治疗后第4、8周末,研究组显效率高于对照组(χ2分别=4.86、5.83,P均<0.05);研究组和对照组治疗后第2、4、8周阳性症状、阴性症状、精神病理、总分均较基线明显下降(t分别=5.05、9.46、12.99、8.12、9.85、17.90、6.54、10.61、15.96、11.61、20.02、28.93、5.49、9.92、11.94、4.98、6.25、10.74、4.18、9.57、14.94、9.20、16.66、23.83,P均<0.05);研究组治疗后第2、4、8周的阴性症状、精神病理和总分均明显大于对照组(t分别=2.50、4.43、7.04、4.65、4.45、6.25、4.40、6.08、8.09,P均<0.05);研究组不良反应发生率和合并用药率低于对照组(χ2分别=6.62、11.76,P均<0.05)。结论氨磺必利治疗MDIA疗效确切,安全性高,优于奋乃静治疗。
目的:比較氨磺必利與奮迺靜治療酒精所緻精神障礙(MDIA)的臨床療效與安全性。方法將100例MDIA患者隨機分成研究組和對照組,每組50例,分彆使用氨磺必利與奮迺靜治療8週,用暘性與陰性綜閤徵量錶(PANSS)評定臨床療效,觀察不良反應。結果在治療後第4、8週末,研究組顯效率高于對照組(χ2分彆=4.86、5.83,P均<0.05);研究組和對照組治療後第2、4、8週暘性癥狀、陰性癥狀、精神病理、總分均較基線明顯下降(t分彆=5.05、9.46、12.99、8.12、9.85、17.90、6.54、10.61、15.96、11.61、20.02、28.93、5.49、9.92、11.94、4.98、6.25、10.74、4.18、9.57、14.94、9.20、16.66、23.83,P均<0.05);研究組治療後第2、4、8週的陰性癥狀、精神病理和總分均明顯大于對照組(t分彆=2.50、4.43、7.04、4.65、4.45、6.25、4.40、6.08、8.09,P均<0.05);研究組不良反應髮生率和閤併用藥率低于對照組(χ2分彆=6.62、11.76,P均<0.05)。結論氨磺必利治療MDIA療效確切,安全性高,優于奮迺靜治療。
목적:비교안광필리여강내정치료주정소치정신장애(MDIA)적림상료효여안전성。방법장100례MDIA환자수궤분성연구조화대조조,매조50례,분별사용안광필리여강내정치료8주,용양성여음성종합정량표(PANSS)평정림상료효,관찰불량반응。결과재치료후제4、8주말,연구조현효솔고우대조조(χ2분별=4.86、5.83,P균<0.05);연구조화대조조치료후제2、4、8주양성증상、음성증상、정신병리、총분균교기선명현하강(t분별=5.05、9.46、12.99、8.12、9.85、17.90、6.54、10.61、15.96、11.61、20.02、28.93、5.49、9.92、11.94、4.98、6.25、10.74、4.18、9.57、14.94、9.20、16.66、23.83,P균<0.05);연구조치료후제2、4、8주적음성증상、정신병리화총분균명현대우대조조(t분별=2.50、4.43、7.04、4.65、4.45、6.25、4.40、6.08、8.09,P균<0.05);연구조불량반응발생솔화합병용약솔저우대조조(χ2분별=6.62、11.76,P균<0.05)。결론안광필리치료MDIA료효학절,안전성고,우우강내정치료。
Objective To compare the clinical efficacy and safety of amisulpiride and perphenazine in treatment of pa-tients with mental disorder induced by alcohol. Methods All 100 patients with mental disorder induced by alcohol were randomly assigned to study group and control group with 50 cases each. The patients were treated with amisupiride or per-phenazine respectively for 8 weeks. The clinical efficacy was evaluated by Positive and Negative Syndrome Scale (PANSS). The adverse reactions were observed. Results The rate of significant efficacy in the study group was significantly higher than that in the control group at the 4th, 8th weekend after treatment(χ2=4.86, 5.83, P<0.05). The positive and negative syndrome, general spirit pathological factors and total scores of PANSS in the both groups after treatment were significantly lower than the baseline(t=5.05, 9.46, 12.99, 8.12, 9.85, 17.90, 6.54, 10.61, 15.96, 11.61, 20.02, 28.93, 5.49, 9.92, 11.94, 4.98, 6.25, 10.74, 4.18, 9.57, 14.94, 9.20, 16.66, 23.83, P<0.05). In the 2nd,4th, 8th weekend after treat-ment, the negative syndrome, general spirit pathological factors and total scores of PANSS in study group was significantly greater than those in the control group(t=2.50, 4.43, 7.04, 4.65, 4.45, 6.25, 4.40, 6.08, 8.09, P<0.05). The incidence of adverse effect and the rate of drug combination in the study group was significantly lower than those in the control group (χ2=6.62, 11.76, P<0.05). Conclusion Amisulpiride is rather effective and safe in treatment of patients with mental disorder induced by alcohol. It is better than perphenazine.