CAJ | 학술논문

目的：观察不同类型房颤患者血浆apelin的水平及其与N端B型利钠肽前体（NT-proBNP）、左房内径（LAD）的关系。方法85例房颤患者分为阵发性房颤组（B组）31例、持续性房颤组（C组）29例和永久性房颤组（D组）25例，同期非房颤住院患者为对照组（A组）26例。检测血浆apelin、NT-proBNP，并行心脏超声测定LAD，进行统计学分析。结果与A组相比，B组、C组、D组血浆apelin水平均明显降低（P均＜0．05），而D组明显低于B组和C组（P均＜0．05），B组与C组之间比较，差异无统计学意义（P＞0．05）；与A组相比，B组、C组、D组NT-proBNP显著升高（P均＜0．05），D组最高，而B组与C组之间比较，差异无统计学意义（P＞0．05）；LAD在A组、B组、C组、D组之间有明显差异，呈依次递增（P＜0．05）。多元相关分析显示：血浆 apelin 与NT-proBNP、LAD负相关，（r＝-0．28、-0．32，P均＜0．05）。结论不同类型房颤患者血浆apelin水平降低，可能通过抗纤维化参与心房重构，与房颤的发生和维持相关。
목적：관찰불동류형방전환자혈장apelin적수평급기여N단B형리납태전체（NT-proBNP）、좌방내경（LAD）적관계。방법85례방전환자분위진발성방전조（B조）31례、지속성방전조（C조）29례화영구성방전조（D조）25례，동기비방전주원환자위대조조（A조）26례。검측혈장apelin、NT-proBNP，병행심장초성측정LAD，진행통계학분석。결과여A조상비，B조、C조、D조혈장apelin수평균명현강저（P균＜0．05），이D조명현저우B조화C조（P균＜0．05），B조여C조지간비교，차이무통계학의의（P＞0．05）；여A조상비，B조、C조、D조NT-proBNP현저승고（P균＜0．05），D조최고，이B조여C조지간비교，차이무통계학의의（P＞0．05）；LAD재A조、B조、C조、D조지간유명현차이，정의차체증（P＜0．05）。다원상관분석현시：혈장 apelin 여NT-proBNP、LAD부상관，（r＝-0．28、-0．32，P균＜0．05）。결론불동류형방전환자혈장apelin수평강저，가능통과항섬유화삼여심방중구，여방전적발생화유지상관。
Objective To explore the relationship among the level of plasma apelin in patients with different types of atrial fibrillation(AF),N-terminal proB-type natriuretic peptide(NT-proBNP),and left atrial diameter (LAD).Methods Eighty-five AF patients were divided into three groups,including 3 1 cases of paroxysmal AF (group B),29 cases of persistent AF(group C),and 25 cases of permanent AF(group D)while 26 inpatients without AF were enrolled as control group over the same period.For the four groups,the levels of plasma apelin and NT-proBNP were detected,LAD was measured by echocardiography,and statistical analysis was performed. Results The levels of plasma apelin in groups B,C,and D were significantly lower than that in group A(P<0.05 for all),and the level of group D was significantly lower than that of groups B and C(P<0.05 for all).The difference of levels of plasma apelin was not statistically significant between group B and group C(P>0.05).Com-pared with group A,the values of NT-proBNP in groups B,C,and D significantly increased(P<0.05 for all), and the value was the highest in group D.The difference of the value of NT-proBNP was not statistically significant between group B and group C(P>0.05 ).There was statistically significant difference of LAD among groups A, B,C,and D(P<0.05 for all),and the values increased gradually.Multiple correlation analysis revealed that the level of plasma apelin was negatively correlated with NT-proBNP and LAD(r=-0.28,-0.32,respectively;P<0.05 for both).Conclusion The decreased plasma apelin level was correlated with the onset and perpetuation of AF,which may be involved in atrial remodeling through anti-fibrosis mechanism.