CAJ | 학술논문

肿瘤血管生成作为肿瘤的主要特征,在肿瘤生长和转移中起着重要作用,为肿瘤治疗提供了新策略.通过标记血管生成相关的受体、多肽、激酶或细胞外基质蛋白,形成高亲和力的分子探针,与肿瘤血管生成过程中产生的特异性靶分子结合,从而显示包括整合素、VEGF/VEGFR、基质金属蛋白酶(MMPs)等与血管生成关系密切的特征性血管生成因子,可从分子水平对肿瘤新生血管及血管靶向治疗疗效进行无创性检测.笔者就肿瘤血管生成PET影像学检测研究进展及未来发展作一综述.
종류혈관생성작위종류적주요특정,재종류생장화전이중기착중요작용,위종류치료제공료신책략.통과표기혈관생성상관적수체、다태、격매혹세포외기질단백,형성고친화력적분자탐침,여종류혈관생성과정중산생적특이성파분자결합,종이현시포괄정합소、VEGF/VEGFR、기질금속단백매(MMPs)등여혈관생성관계밀절적특정성혈관생성인자,가종분자수평대종류신생혈관급혈관파향치료료효진행무창성검측.필자취종류혈관생성PET영상학검측연구진전급미래발전작일종술.
Angiogenesis,a main characteristic in tumors,plays an important role in tumor growth and metastasis,which provides a new strategy for tumor treatment.By marking angiogenesis-related receptors,polypeptides,kinases or extracellular matrix proteins as high affinity molecular probes,PET imaging can noninvasively display integrins,VEGF/VEGFR,matrix metalloproteinases (MMPs) and closely monitor tumor angiogenesis and vascular-targeted treatments on the molecular level.In this paper,research progress and future development of PET imaging for evaluating tumor angiogenesis are reviewed.