中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
1期
39-43
,共5页
梁莺%黄魏宁%陈敏%周妮娜%龚霞
樑鶯%黃魏寧%陳敏%週妮娜%龔霞
량앵%황위저%진민%주니나%공하
磁共振成像%嗅觉
磁共振成像%嗅覺
자공진성상%후각
Magnetic resonance imaging%Olfaction perception
目的 应用功能性磁共振成像(BOLD-fMRI)技术,观察和研究健康青年人和老年人嗅觉中枢的功能定位及其fMRI特征,以此评价年龄对嗅觉中枢的定位、范围及激活强度的影响. 方法 13例健康成年志愿者,青年志愿者8例,年龄为20～28岁,男女比例为5∶3,老年志愿者5例,年龄62～74岁,男女比例为2∶3.刺激模式采用组块设计,以十一烷内酯作为嗅觉刺激剂,两组均采用荷兰Philips公司3.0T的MRI仪器,采集脑部的BOLE-fMRI数据,然后用SPM2软件对数据进行统计学分析,得到脑功能活动图像. 结果 青年组和老年组嗅觉激活区域主要为右侧海马旁回、左侧海马沟和双侧颞上回等,皮质下激活区有右侧丘脑、脑桥背侧部,小脑激活区主要集中在小脑蚓部,而右侧额下回、右侧额中回、右侧枕颞内侧回、右侧海马伞激活仅见于青年组,双侧颞中回激活仅见于老年组.老年组激活区域大小较青年组减小,老年组激活强度较青年组减弱.激活强度男性较女性激活区对应的脑区(右侧顶上小叶、左侧颞上回、右侧颞上回)增强(t值分别为13.7、6.08、5.36,均P＜0.001). 结论 老年人嗅觉中枢激活较青年人减弱,且激活区部分缺失,提示老年人嗅觉中枢功能减退;嗅觉中枢激活有右侧优势偏向,部分激活区男性较女性激活增强.
目的 應用功能性磁共振成像(BOLD-fMRI)技術,觀察和研究健康青年人和老年人嗅覺中樞的功能定位及其fMRI特徵,以此評價年齡對嗅覺中樞的定位、範圍及激活彊度的影響. 方法 13例健康成年誌願者,青年誌願者8例,年齡為20～28歲,男女比例為5∶3,老年誌願者5例,年齡62～74歲,男女比例為2∶3.刺激模式採用組塊設計,以十一烷內酯作為嗅覺刺激劑,兩組均採用荷蘭Philips公司3.0T的MRI儀器,採集腦部的BOLE-fMRI數據,然後用SPM2軟件對數據進行統計學分析,得到腦功能活動圖像. 結果 青年組和老年組嗅覺激活區域主要為右側海馬徬迴、左側海馬溝和雙側顳上迴等,皮質下激活區有右側丘腦、腦橋揹側部,小腦激活區主要集中在小腦蚓部,而右側額下迴、右側額中迴、右側枕顳內側迴、右側海馬傘激活僅見于青年組,雙側顳中迴激活僅見于老年組.老年組激活區域大小較青年組減小,老年組激活彊度較青年組減弱.激活彊度男性較女性激活區對應的腦區(右側頂上小葉、左側顳上迴、右側顳上迴)增彊(t值分彆為13.7、6.08、5.36,均P＜0.001). 結論 老年人嗅覺中樞激活較青年人減弱,且激活區部分缺失,提示老年人嗅覺中樞功能減退;嗅覺中樞激活有右側優勢偏嚮,部分激活區男性較女性激活增彊.
목적 응용공능성자공진성상(BOLD-fMRI)기술,관찰화연구건강청년인화노년인후각중추적공능정위급기fMRI특정,이차평개년령대후각중추적정위、범위급격활강도적영향. 방법 13례건강성년지원자,청년지원자8례,년령위20～28세,남녀비례위5∶3,노년지원자5례,년령62～74세,남녀비례위2∶3.자격모식채용조괴설계,이십일완내지작위후각자격제,량조균채용하란Philips공사3.0T적MRI의기,채집뇌부적BOLE-fMRI수거,연후용SPM2연건대수거진행통계학분석,득도뇌공능활동도상. 결과 청년조화노년조후각격활구역주요위우측해마방회、좌측해마구화쌍측섭상회등,피질하격활구유우측구뇌、뇌교배측부,소뇌격활구주요집중재소뇌인부,이우측액하회、우측액중회、우측침섭내측회、우측해마산격활부견우청년조,쌍측섭중회격활부견우노년조.노년조격활구역대소교청년조감소,노년조격활강도교청년조감약.격활강도남성교녀성격활구대응적뇌구(우측정상소협、좌측섭상회、우측섭상회)증강(t치분별위13.7、6.08、5.36,균P＜0.001). 결론 노년인후각중추격활교청년인감약,차격활구부분결실,제시노년인후각중추공능감퇴;후각중추격활유우측우세편향,부분격활구남성교녀성격활증강.
Objective To investigate the localization,zone and activation intensity of olfactory center in young versus elderly healthy volunteers by functional magnetic resonance imaging (BOLD-fMRI),so as to elucidate the effect of age on olfactory center in healthy population.Methods Thirteen right-handed healthy adult volunteers were recruited and divided into two groups:young group (5 males and 3 females,mean aged 23 years) and elderly group (2 males and 3 females,mean aged 69.2 years).The olfactory stimulus was r-undecalactone,and it was given according to a block design.The fMRI detection was performed on Philips Achieva 3.0 T MR scanner,and data of BOLE-fMRI was processed and analyzed to get cerebration image by using SPM2.Results In groupaveraged maps,both young and elderly group showed significant olfactory activation in right parahippocampal gyrus,left hippocampal sulcus,right and left superior temporal gyrus,etc,subcortical activation in right thalamus,dorsal pons,and cerebellum activation in cerebellar vermis.Activations in right inferior frontal gyrus,right middle frontal gyrus,right medial occipito-temporal gyrus and right fimbria of hippocampus were observed only in young group,while activation in bilateral middle temporal gyrus was observed only in elderly group.Activation area was apparently smaller and activation degree was lower in elderly group than in young group.Activation intensity in right superior parietal lobule and bilateral superior temporal gyri was higher in male group than in female group (t=13.7,6.08,5.36,respectively,all P＜0.001).Conclusions The intensity of activation in olfactory center is lower in the elderly than in the young,and absence of part of the active regions is found in the elderly,which demonstrates the regression of olfactory center in the elderly.The olfactory center shows right-predominant activation,and olfactory activation intensity in some cortical regions is higher in males than in females.
