CAJ | 학술논문

目的：探讨磁共振扩散张量成像（ DTI）技术对脑外伤导致轴索结构损伤的诊断应用价值。方法对22例健康志愿者（对照组）和29例创伤性脑损伤患者（TBI组）进行DTI检查，在工作站上处理获得各向异性（FA）图，测量TBI组和对照组半卵圆中心、胼胝体膝部和压部、内囊前肢和后肢及脑桥的FA值。 TBI组根据临床格拉斯哥昏迷评分（ GCS）分为轻度组（≥13分）和中重度组（≤12分），并分别与对照组进行FA值比较，将TBI组各兴趣区的FA值与临床GCS评分作相关性分析。结果轻度TBI组半卵圆中心FA值下降，中重度TBI组半卵圆中心、胼胝体膝部和压部及内囊前肢和后肢的FA值不同程度下降，差异均有统计学意义（ P ＜0.01）。 TBI组半卵圆中心、胼胝体膝部和压部及内囊前肢和后肢的FA值与GCS评分呈正相关（ P ＜0.05）。结论 DTI是诊断创伤性轴索损伤的敏感序列。 FA值下降能反映神经轴索的损伤及程度，有助于评判TBI的伤情和改善预后。
목적：탐토자공진확산장량성상（ DTI）기술대뇌외상도치축색결구손상적진단응용개치。방법대22례건강지원자（대조조）화29례창상성뇌손상환자（TBI조）진행DTI검사，재공작참상처리획득각향이성（FA）도，측량TBI조화대조조반란원중심、변지체슬부화압부、내낭전지화후지급뇌교적FA치。 TBI조근거림상격랍사가혼미평분（ GCS）분위경도조（≥13분）화중중도조（≤12분），병분별여대조조진행FA치비교，장TBI조각흥취구적FA치여림상GCS평분작상관성분석。결과경도TBI조반란원중심FA치하강，중중도TBI조반란원중심、변지체슬부화압부급내낭전지화후지적FA치불동정도하강，차이균유통계학의의（ P ＜0.01）。 TBI조반란원중심、변지체슬부화압부급내낭전지화후지적FA치여GCS평분정정상관（ P ＜0.05）。결론 DTI시진단창상성축색손상적민감서렬。 FA치하강능반영신경축색적손상급정도，유조우평판TBI적상정화개선예후。
Objective To explore the value of MR diffusion tensor imaging ( DTI) in diagnosis of traumatic Axonal injury ( TAI) .Methods Twenty nine patients with traumatic brain injury ( TBI) and matched 22 control subjects were performed with DTI . Fractional anisotropy ( FA) was calculated from semioval center , corpus callosum , internal capsule and pons of controls and TBI pa-tients.According to Glasgow Score (GCS), TBI patients were divided into mild group (GCS≥13) and moderate-severe group (GCS≤12), each group compared with control group in FA value .The correlation between FA values in different regions and GCS score were analyzed in DTI group .Results FA value of semioval center was decreased in mild DTI group ( P <0.01 ) .FA values of semio-val center , corpus callosum , and internal capsule were decreased in moderate-severe DTI group ( P <0.05 ) .The FA values in semio-val center , corpus callosum , and internal capsule were positively correlated with GCS score in TBI group ( P <0.05 ) .Conclusions DTI is sensitive to detect the traumatic axonal injury??Changes of FA value in ROIs can access the severity of axonal injury ?? which ishelpful for diagnosis earlier and improving prognosis.