CAJ | 학술논문

目的：探讨IL-27在肝癌早期诊断中的临床意义。方法通过ELISA法检测52例肝癌患者（肝癌组）与62例非肝癌患者（对照组）血清IL-27细胞因子水平，运用ROC统计学分析比较其与甲胎蛋白（ AFP）诊断肝癌的诊断效能，Logistic回归分析获得IL-27和AFP两者联合诊断的模型预测肝癌。结果肝癌患者的IL-27浓度[（364.19±177.55）pg/ml]高于对照组[（255.49±94.33）pg/ml， P ＜0.01]；ROC分析IL-27和AFP判断肝癌的曲线下面积（AUC）分别为0.804和0.818，两者对诊断均有统计学意义（ P ＜0.01）；Logistic逐步回归得出的AFP和IL-27回归模型预测值（PRE），判断肝癌的ROC曲线下面积0.901、敏感度84.8％、特异度96.7％较两指标单独诊断时明显提高。结论本研究获得AFP和IL-27的诊断模型，可用于对肝癌的联合诊断。
목적：탐토IL-27재간암조기진단중적림상의의。방법통과ELISA법검측52례간암환자（간암조）여62례비간암환자（대조조）혈청IL-27세포인자수평，운용ROC통계학분석비교기여갑태단백（ AFP）진단간암적진단효능，Logistic회귀분석획득IL-27화AFP량자연합진단적모형예측간암。결과간암환자적IL-27농도[（364.19±177.55）pg/ml]고우대조조[（255.49±94.33）pg/ml， P ＜0.01]；ROC분석IL-27화AFP판단간암적곡선하면적（AUC）분별위0.804화0.818，량자대진단균유통계학의의（ P ＜0.01）；Logistic축보회귀득출적AFP화IL-27회귀모형예측치（PRE），판단간암적ROC곡선하면적0.901、민감도84.8％、특이도96.7％교량지표단독진단시명현제고。결론본연구획득AFP화IL-27적진단모형，가용우대간암적연합진단。
Objective To investigate the clinical significance of IL-27 in hepatocellular carcinoma ( HCC) in the early stage , and to compare it with alpha-fetoprotein ( AFP) in diagnostic performance .Methods Enzyme-linked immunosorbent assay was used to detect the serum level of IL-27 in the HCC group and control group .Receiver operator characteristic ( ROC) curve was used to ana-lyze two indicators and the logistic regression model predicted value ( PRE) was obtained .Results The study indicated the concentra-tion of IL-27 in HCC group [(364.19 ±177.55)pg/ml] was significantly higher than the control group [(255.49 ±94.33)pg/ml], the area under the curve (AUC) of IL-27 and AFP were (0.804) and (0.818), respectively.Logistic regression obtained the regres-sion model PRE that contains AFP and IL-27, with a predicted area under the ROC curve for HCC (0.901), while the diagnostic sen-sitivity (84.8%) and specificity (96.7%) were significantly higher than the capability of individual diagnosis of each indicator .Con-clusions In this study we obtained the model which can be used for clinical diagnosis of hepatocellular carcinoma in future .