CAJ | 학술논문

目的：探究不稳定性心绞痛（ UA）患者血清中血管生成因子质量浓度的变化。方法选取2011年1月至2013年9月在本院心血管内科确诊并接受治疗的不稳定型心绞痛患者60例为实验组，根据葡萄糖耐量试验（ OGTT）结果再分为糖尿病组（A组， n ＝20）和非糖尿病组（B组， n ＝40）。对照组为在本院体检的健康人，共30例。收集血清，然后使用蛋白芯片检测血清中血管内皮生长因子（VEGF）、血管形成蛋白-1（angiopoietin-1）、血管形成蛋白-2（angiopoietin-2）、血管生成素（angio-genin）、血管抑素（angiostatin）、碱性成纤维细胞生长因子（bFGF）和血小板衍生生长因子BB（PDGF-BB）质量浓度，并比较各组间的上述指标差异。结果在UA患者血清中VEGF[（325.2±210.1）pg/ml]和angiopoietin-2[（3031.3±1865.5）pg/ml]质量浓度较对照组显著增高（ P ＜0.05），而angiopoietin-1、angiogenin、angiostatin、bFGF和PDGF-BB的两组之间比较差异无统计学意义（ P ＞0.05）。糖尿病组与非糖尿病组间的7项主要血清血管生成因子浓度差异无统计学意义（ P ＞0.05）。结论UA患者血清中血管内皮生长因子、血管形成蛋白-2浓度明显增高，糖尿病并不影响这种变化。
목적：탐구불은정성심교통（ UA）환자혈청중혈관생성인자질량농도적변화。방법선취2011년1월지2013년9월재본원심혈관내과학진병접수치료적불은정형심교통환자60례위실험조，근거포도당내량시험（ OGTT）결과재분위당뇨병조（A조， n ＝20）화비당뇨병조（B조， n ＝40）。대조조위재본원체검적건강인，공30례。수집혈청，연후사용단백심편검측혈청중혈관내피생장인자（VEGF）、혈관형성단백-1（angiopoietin-1）、혈관형성단백-2（angiopoietin-2）、혈관생성소（angio-genin）、혈관억소（angiostatin）、감성성섬유세포생장인자（bFGF）화혈소판연생생장인자BB（PDGF-BB）질량농도，병비교각조간적상술지표차이。결과재UA환자혈청중VEGF[（325.2±210.1）pg/ml]화angiopoietin-2[（3031.3±1865.5）pg/ml]질량농도교대조조현저증고（ P ＜0.05），이angiopoietin-1、angiogenin、angiostatin、bFGF화PDGF-BB적량조지간비교차이무통계학의의（ P ＞0.05）。당뇨병조여비당뇨병조간적7항주요혈청혈관생성인자농도차이무통계학의의（ P ＞0.05）。결론UA환자혈청중혈관내피생장인자、혈관형성단백-2농도명현증고，당뇨병병불영향저충변화。
Objective To explore the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris.Methods A total of 60 patients with unstable angina pectoris was eligible for study and divided into diabetes group ( A group, n =20) and non-diabetes group (B group, n =40).Another 30 general-matched healthy subjects from medical examination center were enrolled as control group .Serum samples were collected , and serum concentrations of vascular endothelial growth factor (VEGF), angiopoietin-1, angiopoietin-2, angiogenin, angiostatin, basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB ( PDGF-BB) were measured by cytokine array technology and compared between the groups .Results Compared with the control group, the serum concentrations of VEGF [(325.2 ±210.1)pg/ml] and angiopoietin-2 [(3031.3 ±1865.5)pg/ml] were sig-nificantly increased in patients with unstable angina pectoris (both P <0.05).Whereas,no significant differences in serum concentra-tions of angiogenin,angiopoietin-1,angiostatin,bFGF,and PDGF-BB were detected between control group and patient groups .There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group .Con-clusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris ,and diabetes didn't affect the increases in serum concentrations of VEGF and angiopoietin-2 caused by unstable angina pectoris .