中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2014年
7期
4561-4562
,共2页
盛喜霞%王兆杰%杨利娟%郑燕
盛喜霞%王兆傑%楊利娟%鄭燕
성희하%왕조걸%양리연%정연
卡前列甲酯栓%米非司酮%利凡诺%终止妊娠
卡前列甲酯栓%米非司酮%利凡諾%終止妊娠
잡전렬갑지전%미비사동%리범낙%종지임신
Carboprost methylate suppositories%Mifepristone%Rivanol%Ending pregnancy
目的：研究卡前列甲酯栓联合米非司酮终止中期妊娠与利凡诺引产的疗效比较。方法：选择113例孕周在14～27周之间要求终止妊娠的孕妇，按照随机对照的原则将其分为观察组55例，对照组58例。观察组于早晚各服用米非司酮片50 mg，服药前后2小时空腹，连服3 d（月份较小者可酌情减药），3 d后根据宫颈软化程度及宫缩情况，每隔3-6 h阴道后穹隆放置卡前列甲酯栓1 mg，并卧床30分钟，最大剂量不超过4 mg。对照组予以羊膜腔内注入稀释后的乳酸依沙吖啶100 mg终止妊娠。观察比较两组的临床疗效。结果：完全流产率比较，观察组为81.81％，对照组为63.79％，P＜0.05，差异有统计学意义；流产时间比较，观察组为5.82±2.65 h，对照组为58.24±3.48 h，P＜0.05，差异有统计学意义；阴道出血量比较，观察组为89.43±6.28ml，对照组为168.56±23.32 ml，P＜0.05，差异有统计学意义。结论：卡孕栓与米非司酮联合用于中期妊娠引产，解决了中期妊娠孕周小，羊水少，穿刺困难、宫颈条件不成熟等问题，避免了宫腔操作和宫内感染的可能，安全无创，经济便利，可操作性强，值得临床推广应用。
目的：研究卡前列甲酯栓聯閤米非司酮終止中期妊娠與利凡諾引產的療效比較。方法：選擇113例孕週在14～27週之間要求終止妊娠的孕婦，按照隨機對照的原則將其分為觀察組55例，對照組58例。觀察組于早晚各服用米非司酮片50 mg，服藥前後2小時空腹，連服3 d（月份較小者可酌情減藥），3 d後根據宮頸軟化程度及宮縮情況，每隔3-6 h陰道後穹隆放置卡前列甲酯栓1 mg，併臥床30分鐘，最大劑量不超過4 mg。對照組予以羊膜腔內註入稀釋後的乳痠依沙吖啶100 mg終止妊娠。觀察比較兩組的臨床療效。結果：完全流產率比較，觀察組為81.81％，對照組為63.79％，P＜0.05，差異有統計學意義；流產時間比較，觀察組為5.82±2.65 h，對照組為58.24±3.48 h，P＜0.05，差異有統計學意義；陰道齣血量比較，觀察組為89.43±6.28ml，對照組為168.56±23.32 ml，P＜0.05，差異有統計學意義。結論：卡孕栓與米非司酮聯閤用于中期妊娠引產，解決瞭中期妊娠孕週小，羊水少，穿刺睏難、宮頸條件不成熟等問題，避免瞭宮腔操作和宮內感染的可能，安全無創，經濟便利，可操作性彊，值得臨床推廣應用。
목적：연구잡전렬갑지전연합미비사동종지중기임신여리범낙인산적료효비교。방법：선택113례잉주재14～27주지간요구종지임신적잉부，안조수궤대조적원칙장기분위관찰조55례，대조조58례。관찰조우조만각복용미비사동편50 mg，복약전후2소시공복，련복3 d（월빈교소자가작정감약），3 d후근거궁경연화정도급궁축정황，매격3-6 h음도후궁륭방치잡전렬갑지전1 mg，병와상30분종，최대제량불초과4 mg。대조조여이양막강내주입희석후적유산의사아정100 mg종지임신。관찰비교량조적림상료효。결과：완전유산솔비교，관찰조위81.81％，대조조위63.79％，P＜0.05，차이유통계학의의；유산시간비교，관찰조위5.82±2.65 h，대조조위58.24±3.48 h，P＜0.05，차이유통계학의의；음도출혈량비교，관찰조위89.43±6.28ml，대조조위168.56±23.32 ml，P＜0.05，차이유통계학의의。결론：잡잉전여미비사동연합용우중기임신인산，해결료중기임신잉주소，양수소，천자곤난、궁경조건불성숙등문제，피면료궁강조작화궁내감염적가능，안전무창，경제편리，가조작성강，치득림상추엄응용。
To study the effect of carboprost methylate suppositories combined with mifepristone on ending Mid-pregnancy. Methods:113cases pregnant women who had Mid-pregnancy in hospital from 2012 October to 2013 October were slected and required to ending pregnancy. The 113 patients were randomly divided into observation group and control group. There are 55cases in the observation group and 58cases in the control group. The observation group were given mifepristone 50 mg, one time at morning and night, Medication before and after 2 hours of fasting,even for 3 days,3 days later, according to the degree of cervical softening and uterine contraction, Every 3-6 h posterior vaginal fornix placed Carboprost methylate suppositorites 1 mg, and stay in bed for 30 minutes, The maximum dose does not exceed 4mg. The control group was given amniotic cavity injection of Ethacridine lactate 100 mg to ending pregnancy. To compared the clinical efficacy of two groups.Results:To compare the complete abortion rate of observation group and control group, the observation group was 81.81%, the control group was 63.79%, P<0.05,there was significant difference between two groups; To compare the arbortive time of observation group and control group ,the observation group was 5.82±2.65 h , the control group was 58.24±3.48 h, P<0.05,there was significant difference between two groups; To compare the vaginal bleeding volume of observation group and control group, the observation group was 89.43±6.28 ml, the control group was 168.56±23.32 ml, P<0.05,there was significant difference between two groups . Conclution:Carboprost methylate suppositories combined with mifepristone on ending Mid-pregnancy, to solve the problem of short gestational weeks, less amniotic fluid, puncture difficulties, and cervical conditions are not ripe, To avoid the possibility of uterine cavity operation and intrauterine infection, safe and noninvasive, economic and convenience, easy to operate. It is worthy of clinical promotion.
