CAJ | 학술논문

目的：分析铜绿假单胞菌（PA）的临床分布及耐药性，为临床治疗PA感染提供参考依据。方法：采用常规方法分离，用Microscan walkAway一96全自动微生物分析仪进行菌种鉴定，用K-B法进行药敏试验。细菌分离培养按照《全国临床检验操作规程》(第3版)进行，药敏结果按照美国临床实验室标准化研究所(CLSI)标准进行结果判断。采用WH0NET5．4完成数据的统计分析。结果：269株PA主要来源于痰（共201株，占74.7%）其次为尿和分泌物（分别为14株，各占5.2%）。PA对阿米卡星的敏感性最高，其次依次为哌拉西林（他唑巴坦）、美罗培南、头孢吡肟、亚胺培南。结论：PA 主要引起呼吸系统的感染，其次为泌尿系统。PA 对阿米卡星的敏感性最高，其次为哌拉西林（他唑巴坦）、美罗培南等，临床应根据药敏试验结果选择合适的抗菌药物，降低PA的耐药性。
목적：분석동록가단포균（PA）적림상분포급내약성，위림상치료PA감염제공삼고의거。방법：채용상규방법분리，용Microscan walkAway일96전자동미생물분석의진행균충감정，용K-B법진행약민시험。세균분리배양안조《전국림상검험조작규정》(제3판)진행，약민결과안조미국림상실험실표준화연구소(CLSI)표준진행결과판단。채용WH0NET5．4완성수거적통계분석。결과：269주PA주요래원우담（공201주，점74.7%）기차위뇨화분비물（분별위14주，각점5.2%）。PA대아미잡성적민감성최고，기차의차위고랍서림（타서파탄）、미라배남、두포필우、아알배남。결론：PA 주요인기호흡계통적감염，기차위비뇨계통。PA 대아미잡성적민감성최고，기차위고랍서림（타서파탄）、미라배남등，림상응근거약민시험결과선택합괄적항균약물，강저PA적내약성。
To determine the distribution rate and antibiotics resistance pattern in P.aeruginosa among clinical isolates by retrospective analysis and provide reference for the choice of therapy for P.aeruginosa infections. Methods:The strains of P.aeruginosawere isolated from different clinical specimens were characterized was carried out by the by MicroScan WalkAway96 plus Instrument. The antibiotics susceptibility patterns of each isolate were determined by K-B method according to the CLSI guideline. The statistic analysis of drug resistance was performed by WHONET 5.4 software.Results: The majority of the 249 P.aeruginosa were from sputum samples (201/249, 74.7%), the rest were from urine (14/249, 5.2%) and (14/249, 5.2%). The most effective antibiotic is Amikacin, followed by piperacillin (tazobactam), meropenem, cefepime and imipenem. Conclusion: Respiratory tract infections and urinary tract infections were the most common P. aeruginosa sources. The most effective antibiotic is Amikacin, followed by piperacillin (tazobactam), meropenem, cefepime and imipenem.