CAJ | 학술논문

目的：探讨中西医结合治疗肠外营养相关性胆汁淤积症（PNAC）的效果。方法：回顾分析本院2005年1月-2012年12月收治的极低体重儿，其中发生PN相关性PNAC的患儿37例，随机分为治疗组19例，对照组18例；治疗组采用中西医结合方法治疗：茵栀黄1.5g口服，2次/d，熊去氧胆酸20-30mg/kg.d,分2次口服，同时每天由专业护士按摩腹部2次，15分钟/次，出院后则由其母亲进行，另外，若超过48小时无排便即给与温盐水灌肠通便。对照组：熊去氧胆酸20-30mg/kg.d,分2次口服，必要时予以温盐水灌肠通便；比较两组的治疗效果。结果：治疗组在治疗10天，20天后总胆红素(TBIL)、直接胆红素(DBIL)、胆汁酸(TBA)下降数值明显大于对照组（P＜0.05），两组肝肾功无明显差异，而且两组均无明显不良反应。结论：中西医结合治疗PN相关性PNAC具有更好的疗效。
목적：탐토중서의결합치료장외영양상관성담즙어적증（PNAC）적효과。방법：회고분석본원2005년1월-2012년12월수치적겁저체중인，기중발생PN상관성PNAC적환인37례，수궤분위치료조19례，대조조18례；치료조채용중서의결합방법치료：인치황1.5g구복，2차/d，웅거양담산20-30mg/kg.d,분2차구복，동시매천유전업호사안마복부2차，15분종/차，출원후칙유기모친진행，령외，약초과48소시무배편즉급여온염수관장통편。대조조：웅거양담산20-30mg/kg.d,분2차구복，필요시여이온염수관장통편；비교량조적치료효과。결과：치료조재치료10천，20천후총담홍소(TBIL)、직접담홍소(DBIL)、담즙산(TBA)하강수치명현대우대조조（P＜0.05），량조간신공무명현차이，이차량조균무명현불량반응。결론：중서의결합치료PN상관성PNAC구유경호적료효。
To investigate the combined treatment effect of the traditional Chinese and Western medicine on parenteral nutrition associated cholestasis ( PNAC ). Methods: Retrospective analysis the 37 cases of very low birth weight infants with PNAC in our hospital from Jan 2005 to Dec 2012 .They were randomly divided into the treatment group of 19 cases, control group of 18 cases; treatment group were treated with traditional Chinese and Western medicine: Yinzhihuang 1.5g PO, twice a day , Ursodeoxycholic acid 20-30mg/ kg.d, administered in twice. At the same time massage abdomen by professional nurses twice a day , 15 minutes each time, which is done by their mothers afterdischarge. if they have no defecation in more than 48 hours, they were given warm saline enema catharsis. Control group: Ursodeoxycholic acid 20-30mg/kg.d, administered in twice. if necessary, warm saline enema catharsis was applied.Results: with 10 days, 20 days of treatment, total bilirubin ( TBIL ), direct bilirubin ( DBIL ), bile acid ( TBA ) of treatment group decrease more significant than the control group ( P < 0.05 ); no significant difference of liver and kidney function between the two groups, and both groups had no obvious adverse reactions. Conclusion: the combined effect of traditional Chinese and Western medicine on PNAC is beter than that of Western medicine only .