中国保健营养(中旬刊)
中國保健營養(中旬刊)
중국보건영양(중순간)
China Hwalth Care & nutrition
2014年
7期
4085-4085
,共1页
韩丽红%闫斌%秦艳晶%于跃利
韓麗紅%閆斌%秦豔晶%于躍利
한려홍%염빈%진염정%우약리
肝癌%血清Bcl-2%血管内皮生长因子%凋亡%基因表达
肝癌%血清Bcl-2%血管內皮生長因子%凋亡%基因錶達
간암%혈청Bcl-2%혈관내피생장인자%조망%기인표체
hepatic carcinoma%serum Bcl-2%vascular endothelial growth factor%apoptosis%gene expression
目的:通过检测血清Bcl-2、血管内皮生长因子的水平,以研究其在肝癌中表达的意义。方法:选取2011年2月~2012年12月入我院经临床确诊为50例肝癌患者为观察组,50例正常者为对照组。检测两组患者血清 Bcl-2、血管内皮生长因子的含量及表达阳性率,并分析比较检测结果。结果:观察组患者血清 Bcl-2、血管内皮生长因子的表达阳性率均明显大于对照组(98%>20%、100%>30%),两组相比较差别具有统计学意义(P<0.05);观察组和对照组的血清Bcl-2的水平分别为(102±40) U/L、(45±30)U/L,观察组显著高于对照组,两组相比较差别具有统计学意义(P<0.05);观察组和对照组的血管内皮生长因子水平分别为(415.2±140.3)ng/L、(160.5±65.8)ng/L,观察组明显高于对照组,两组相比较差别具有统计学意义(P<0.05)。结论:肝癌患者的血清Bcl-2、血管内皮生长因子检出率明显高于正常者,且血清中含量多于正常者,对肝癌疾病的预后及治疗有着重要的临床意义。
目的:通過檢測血清Bcl-2、血管內皮生長因子的水平,以研究其在肝癌中錶達的意義。方法:選取2011年2月~2012年12月入我院經臨床確診為50例肝癌患者為觀察組,50例正常者為對照組。檢測兩組患者血清 Bcl-2、血管內皮生長因子的含量及錶達暘性率,併分析比較檢測結果。結果:觀察組患者血清 Bcl-2、血管內皮生長因子的錶達暘性率均明顯大于對照組(98%>20%、100%>30%),兩組相比較差彆具有統計學意義(P<0.05);觀察組和對照組的血清Bcl-2的水平分彆為(102±40) U/L、(45±30)U/L,觀察組顯著高于對照組,兩組相比較差彆具有統計學意義(P<0.05);觀察組和對照組的血管內皮生長因子水平分彆為(415.2±140.3)ng/L、(160.5±65.8)ng/L,觀察組明顯高于對照組,兩組相比較差彆具有統計學意義(P<0.05)。結論:肝癌患者的血清Bcl-2、血管內皮生長因子檢齣率明顯高于正常者,且血清中含量多于正常者,對肝癌疾病的預後及治療有著重要的臨床意義。
목적:통과검측혈청Bcl-2、혈관내피생장인자적수평,이연구기재간암중표체적의의。방법:선취2011년2월~2012년12월입아원경림상학진위50례간암환자위관찰조,50례정상자위대조조。검측량조환자혈청 Bcl-2、혈관내피생장인자적함량급표체양성솔,병분석비교검측결과。결과:관찰조환자혈청 Bcl-2、혈관내피생장인자적표체양성솔균명현대우대조조(98%>20%、100%>30%),량조상비교차별구유통계학의의(P<0.05);관찰조화대조조적혈청Bcl-2적수평분별위(102±40) U/L、(45±30)U/L,관찰조현저고우대조조,량조상비교차별구유통계학의의(P<0.05);관찰조화대조조적혈관내피생장인자수평분별위(415.2±140.3)ng/L、(160.5±65.8)ng/L,관찰조명현고우대조조,량조상비교차별구유통계학의의(P<0.05)。결론:간암환자적혈청Bcl-2、혈관내피생장인자검출솔명현고우정상자,차혈청중함량다우정상자,대간암질병적예후급치료유착중요적림상의의。
To detect serum Bcl-2, vascular endothelial growth factor levels in order to study the significance of its expression in HCC .Methods:February 2011 - December 2012 into the hospital clinicaly diagnosed 50 cases of liver cancer patients in the observation group, 50 cases of normal control group. Serum were detected Bcl-2, vascular endothelial growth factor levels and positive expression rate, compare and analyze the test results.Results:The serum Bcl-2, vascular endothelial growth factor expression positive rate was significantly higher than the control group ( 98% > 20% and 100 %> 30% ) , compared to the difference between the two groups was statisticaly significant (P <0.05 ) ; serum levels of Bcl-2 in the observation group and the control group were (102 ± 40) U / L, (45 ± 30) U / L, the observation group was significantly higher , compared to the difference between the two groups was statisticaly significance (P <0.05); observation group and the control group of vascular endothelial growth factor levels were (415.2 ± 140.3) ng / L, (160.5 ± 65.8) ng / L, the observation group was significantly higher, compared to the two groups the difference was statisticaly significant (P <0.05).Conclusion:The serum of patients with hepatocelular carcinoma Bcl-2, vascular endothelial growth factor detection rate was significantly higher than normal, and the serum levels than normal , prognosis and treatment of liver disease has important clinical significance.