现代医院
現代醫院
현대의원
MODERN HOSPITAL
2014年
7期
83-85
,共3页
儿科重症监护病房%合理用药%潜在药物相互作用%不良反应
兒科重癥鑑護病房%閤理用藥%潛在藥物相互作用%不良反應
인과중증감호병방%합리용약%잠재약물상호작용%불량반응
Peditric Intensive Care Unit%Rational administration of drugs%Potential drug-drug interactions%Ad-verse reaction
目的：了解儿科重症监护病房（ PICU）患儿用药情况并讨论其合理性。方法采用回顾性分析的方法对中山大学附属第一医院46例PICU患儿的进行用药分析，入院时间是2011年5月3日～12月5日，平均年龄（34.74±45.5）月。根据药典、说明书等相关资料对用药情况进行评价。结果46例患儿中，有28例（60.87％）患儿存在用药安全问题，涉及潜在药物相互作用、配伍禁忌等共100例次。涉及配伍禁忌和 pDDIs排名前四的药物是呋塞米16例（16％）、万古霉素和地塞米松12例（12％）、咪达唑仑注射液11例（11％）、苯巴比妥9例（9％）。结论根据儿科用药的特点，减少药理作用相似的合并用药，关注常用药物的配伍禁忌和潜在相互作用，加强临床药师对儿科重症监护病房用药审查。
目的：瞭解兒科重癥鑑護病房（ PICU）患兒用藥情況併討論其閤理性。方法採用迴顧性分析的方法對中山大學附屬第一醫院46例PICU患兒的進行用藥分析，入院時間是2011年5月3日～12月5日，平均年齡（34.74±45.5）月。根據藥典、說明書等相關資料對用藥情況進行評價。結果46例患兒中，有28例（60.87％）患兒存在用藥安全問題，涉及潛在藥物相互作用、配伍禁忌等共100例次。涉及配伍禁忌和 pDDIs排名前四的藥物是呋塞米16例（16％）、萬古黴素和地塞米鬆12例（12％）、咪達唑崙註射液11例（11％）、苯巴比妥9例（9％）。結論根據兒科用藥的特點，減少藥理作用相似的閤併用藥，關註常用藥物的配伍禁忌和潛在相互作用，加彊臨床藥師對兒科重癥鑑護病房用藥審查。
목적：료해인과중증감호병방（ PICU）환인용약정황병토론기합이성。방법채용회고성분석적방법대중산대학부속제일의원46례PICU환인적진행용약분석，입원시간시2011년5월3일～12월5일，평균년령（34.74±45.5）월。근거약전、설명서등상관자료대용약정황진행평개。결과46례환인중，유28례（60.87％）환인존재용약안전문제，섭급잠재약물상호작용、배오금기등공100례차。섭급배오금기화 pDDIs배명전사적약물시부새미16례（16％）、만고매소화지새미송12례（12％）、미체서륜주사액11례（11％）、분파비타9례（9％）。결론근거인과용약적특점，감소약리작용상사적합병용약，관주상용약물적배오금기화잠재상호작용，가강림상약사대인과중증감호병방용약심사。
Objective To evaluate the rationality of medication in Pediatric Intensive Care Unit (PICU).Methods The medication of 46 children in PICU of the First Affiliated Hospital of Sun Yat-Sen University with the average age of (34.74 ±45.5) months during May 3, 2011 and December 5, 2011 were retrospectively analyzed.The study was conducted statistically on the basis of pharmacopoeia, medical documents and other related medical materials.Results Among 46 ca-ses, irrational drug use was found in 28 patients (60.87%).A total of 100 irrational drug using habits such as potential drug interactions and incompatibility were presented.Compatibility taboo and pDDIs top four drugs were16 cases of furosemide (16%), 12 cases of vancomycin and dexamethasone (12%), 11 cases of midazolam injection (11%), and 9 cases of Phe-nobarbital (9%).Conclusion According to the characteristics of pediatric medication, pharmacists should take advantage of drug synergy when vigilant about the side effects of multi -medication, especially paying close attention to the potential inter-action of some commonly-prescribed drugs as well as reducing the prescriptions of multi -medications in order to improve the rationality of drug use in PICU.
