CAJ | 학술논문

目的：探讨艾司洛尔联合硝酸甘油在高血压脑出血术中的应用。方法将72例急诊脑出血手术（入选标准为SBP≥200 mmHg）的患者随机分为A、B组，A组（n＝36）为艾司洛尔联合硝酸甘油；B组（n＝36）硝酸甘油组。观察分析A、B组患者血流动力学、术中出血及麻醉时间。结果两组MAP与同组T0相比较T1、T2、T3均明显降低（p＜0.05），A组与B组MAP在各时点间比较无统计学差异。 B 组 HR 在 T1、T2、T3较 T0时点明显增快（p ＜0.05），A组T2、T3、T4心率较T0时点明显减低（p＜0.05）；A组T1、T2、T3、T4时点HR较B组同时点降低（p＜0.01）。结论艾司洛尔联合硝酸甘油对高血压脑出血手术干预有一定优势。
목적：탐토애사락이연합초산감유재고혈압뇌출혈술중적응용。방법장72례급진뇌출혈수술（입선표준위SBP≥200 mmHg）적환자수궤분위A、B조，A조（n＝36）위애사락이연합초산감유；B조（n＝36）초산감유조。관찰분석A、B조환자혈류동역학、술중출혈급마취시간。결과량조MAP여동조T0상비교T1、T2、T3균명현강저（p＜0.05），A조여B조MAP재각시점간비교무통계학차이。 B 조 HR 재 T1、T2、T3교 T0시점명현증쾌（p ＜0.05），A조T2、T3、T4심솔교T0시점명현감저（p＜0.05）；A조T1、T2、T3、T4시점HR교B조동시점강저（p＜0.01）。결론애사락이연합초산감유대고혈압뇌출혈수술간예유일정우세。
Objective To explore the application of nitroglycerin combined with esmolol in hypertensive cerebral hemorrhage surgery.Methods 72 patients undergoing emergency surgery for cerebral hemorrhage ( inclusion criteria: SBP≥200 mmHg) were randomly divided into two groups (Group A and Group B).Nitroglycerin combined with esmolol was used in Group A (n=36); nitroglycerin was used in Group B (n=36).Hemodynamics, the intraoperative blood loss and the duration of anesthesia in patients in Group A and Group B were observed and statistically analyzed .Results Compared to T0, MAP in both two groups at T1, T2 and T3 were decreased significantly (p<0.05).There were no significant differences between Group A and Group B in MAP at any time points.Compared to T0 , HR at T1 , T2 and T3 in Group B were increased significantly (p<0.05), while HR at T2, T3 and T4 in Group A were decreased significantly (p<0.05).HR at T1,T2, T3 and T4 in Group A were lower than those in Group B (p<0.01).Conclusion Nitroglycerin combined with esmolol on inter-vention for hypertensive cerebral hemorrhage surgery has certain advantages.