CAJ | 학술논문

目的：比较富血小板血浆（PRP）和羟基磷灰石（HA）联合或单独应用HA对中、重度慢性牙周炎患者牙周骨缺损修复的疗效。方法：选择中、重度慢性牙周炎患者20例共20个骨缺损的患牙，随机分为2组，HA/PRP组于骨缺损区同时植入PRP与HA，HA组单独植入HA。术后3、6个月时观察牙龈退缩（GR）、探诊深度（PD）、临床附着水平（CAL）、牙周再附着的变化，并评估骨缺损高度和骨密度的改变，以平均光密度值变化（MOD）作为参考。结果：术后3、6个月相比两组的GR、PD、CAL无显著差异。牙周再附着方面，HA/PRP组术后3个月时显著优于HA组（P＜0．05），6个月时两组无统计学差异（P＞0．05）。术后3、6个月时HA/PRP组MOD值均明显高于HA组（P＜0．05）。结论：HA、HA/PRP均为治疗牙周骨缺损的有效方法；PRP对牙周骨缺损修复有一定的促进作用，并在术后3个月即可达到相对稳定的水平。
목적：비교부혈소판혈장（PRP）화간기린회석（HA）연합혹단독응용HA대중、중도만성아주염환자아주골결손수복적료효。방법：선택중、중도만성아주염환자20례공20개골결손적환아，수궤분위2조，HA/PRP조우골결손구동시식입PRP여HA，HA조단독식입HA。술후3、6개월시관찰아간퇴축（GR）、탐진심도（PD）、림상부착수평（CAL）、아주재부착적변화，병평고골결손고도화골밀도적개변，이평균광밀도치변화（MOD）작위삼고。결과：술후3、6개월상비량조적GR、PD、CAL무현저차이。아주재부착방면，HA/PRP조술후3개월시현저우우HA조（P＜0．05），6개월시량조무통계학차이（P＞0．05）。술후3、6개월시HA/PRP조MOD치균명현고우HA조（P＜0．05）。결론：HA、HA/PRP균위치료아주골결손적유효방법；PRP대아주골결손수복유일정적촉진작용，병재술후3개월즉가체도상대은정적수평。
AIM:To study the clinical effects of hydroxyapatite (HA)plus platelet-rich plasma (PRP)in the treatment of periodontal bone defect.METHODS:20 patients with moderate or severe chronic periodontitis and displaying at least one tooth with advanced intrabony defect were included.The teeth with lesions were randomly treated with HA/PRP and HA respectively.X-ray films and following clinical parameters were assessed before and after sur-gery:gingival recession (GR),probing depth (PD),and clinical attachment level (CAL).The change of mean opti-cal density(MOD)value of the bone defect are a was taken as a reference for bone mineral density.RESULTS:There was no significant difference between the two groups in GR,PD or CAL at 3 or 6 months after surgery.The HA/PRP group showed a more significant CAL gain at 3 months after surgery than that of the HA group (P<0.05),but not at 6 months(P>0.05).The X-ray films showed MOD was significantly higher in HA/PRP group than that in HA group at 3 months and 6 months after surgery (P<0.05).CONCLUSION:Both HA and HA/PRP are effective in the treat-ment of periodontal bone defect.PRP has a promoting effect on the mineralization of new bone.