世界中西医结合杂志
世界中西醫結閤雜誌
세계중서의결합잡지
WORLD JOURNAL OF TRADITIONAL CHINESE AND WESTERN MEDICINE
2014年
7期
736-739
,共4页
补肾益冲丸%肾虚%排卵障碍性不孕%临床研究
補腎益遲汍%腎虛%排卵障礙性不孕%臨床研究
보신익충환%신허%배란장애성불잉%림상연구
BushenyichongPills%KidneyDeficiency%OvulatoryDysfunctionalInfertility%ClinicalRe-search
目的:研究基于补肾益冲丸的中西医结合优化方案治疗肾虚型排卵障碍性不孕的临床疗效及安全性。方法将360例肾虚型排卵障碍性不孕患者随机分为补肾益冲丸组(补肾益冲丸+电针)、克罗米酚组[克罗米酚(clomiphene citrate,CC)+人绒毛膜促性腺激素(human chorionic gon-adotrophin,HCG)]及补肾益冲丸优化治疗组(补肾益冲丸+CC+电针+HCG)。三种治疗方案均设定3个月为1个疗程。纳入患者共接受1~4个疗程治疗后评价各方案疗效。结果补肾益冲丸优化治疗组的子宫内膜厚度、周期排卵率及妊娠率均显著高于克罗米酚组,但流产率显著低于克罗米酚组(P<0.05)。子宫内膜厚度、最大卵泡直径及流产率在补肾益冲丸组与补肾益冲丸组优化治疗组比较,差异无统计学意义(P>0.05),但补肾益冲丸优化治疗组的周期排卵率及妊娠率显著高于补肾益冲丸组(P<0.05)。结论补肾益冲丸优化治疗方案可显著提高肾虚型排卵障碍性不孕患者的周期排卵率及妊娠率,并可改善子宫内膜容受性及降低流产率。
目的:研究基于補腎益遲汍的中西醫結閤優化方案治療腎虛型排卵障礙性不孕的臨床療效及安全性。方法將360例腎虛型排卵障礙性不孕患者隨機分為補腎益遲汍組(補腎益遲汍+電針)、剋囉米酚組[剋囉米酚(clomiphene citrate,CC)+人絨毛膜促性腺激素(human chorionic gon-adotrophin,HCG)]及補腎益遲汍優化治療組(補腎益遲汍+CC+電針+HCG)。三種治療方案均設定3箇月為1箇療程。納入患者共接受1~4箇療程治療後評價各方案療效。結果補腎益遲汍優化治療組的子宮內膜厚度、週期排卵率及妊娠率均顯著高于剋囉米酚組,但流產率顯著低于剋囉米酚組(P<0.05)。子宮內膜厚度、最大卵泡直徑及流產率在補腎益遲汍組與補腎益遲汍組優化治療組比較,差異無統計學意義(P>0.05),但補腎益遲汍優化治療組的週期排卵率及妊娠率顯著高于補腎益遲汍組(P<0.05)。結論補腎益遲汍優化治療方案可顯著提高腎虛型排卵障礙性不孕患者的週期排卵率及妊娠率,併可改善子宮內膜容受性及降低流產率。
목적:연구기우보신익충환적중서의결합우화방안치료신허형배란장애성불잉적림상료효급안전성。방법장360례신허형배란장애성불잉환자수궤분위보신익충환조(보신익충환+전침)、극라미분조[극라미분(clomiphene citrate,CC)+인융모막촉성선격소(human chorionic gon-adotrophin,HCG)]급보신익충환우화치료조(보신익충환+CC+전침+HCG)。삼충치료방안균설정3개월위1개료정。납입환자공접수1~4개료정치료후평개각방안료효。결과보신익충환우화치료조적자궁내막후도、주기배란솔급임신솔균현저고우극라미분조,단유산솔현저저우극라미분조(P<0.05)。자궁내막후도、최대란포직경급유산솔재보신익충환조여보신익충환조우화치료조비교,차이무통계학의의(P>0.05),단보신익충환우화치료조적주기배란솔급임신솔현저고우보신익충환조(P<0.05)。결론보신익충환우화치료방안가현저제고신허형배란장애성불잉환자적주기배란솔급임신솔,병가개선자궁내막용수성급강저유산솔。
Objective Tostudytheclinicalefficacyandsafetyinthetreatmentofovulatorydys-functional infertility of kidney deficiency pattern with the optimization program of integrated Chinese and westernmedicinewithBushenyichongPills.Methods Threehundredandsixtycaseswererandomizedinto Bushenyichong Pills group[Pills +Electroacupuncture(EA)group],Clomiphen Citrate group[Clomiphen Citrate(CC)+HCG group]and the optimization program group(Pills +CC+EA+HCG).The treatment of 3 months made 1 session.The included patients received 1 to 4 sessions of treatment.The efficacy was as-sessedaftertreatmentwitheachprogram.Results Intheoptimizationprogramgroup,theendometrialthick-ness,cycle ovulation rate and pregnancy rate were all significantly higher than those in Clomiphene Citrate group,but the miscarriage rate was significantly lower than that in Clomiphene Citrate group(P<0.05).The differences in endometrial thickness,maximal follicular diameter and miscarriage rate were not significant be-tween Bushenyichong Pills group and the optimization program group(P>0.05).The cycle ovulation rate and pregnancy rate in the optimization program group were significantly higher than those in Bushenyichong Pillsgroup(P<0.05).Conclusion TheoptimizationprogramwithBushenyichongPillssignificantlyim-proves cycle ovulation rate and pregnancy rate,improves endometrial endurance and reduces miscarriage rate in the patients of ovulatory dysfunctional infertility of kidney deficiency pattern.