CAJ | 학술논문

目的：通过动物实验探讨蒿秦通痹胶囊抗类风湿性关节炎的作用机理。方法分别采用健康Wistar大鼠、小鼠复制类风湿关节炎模型，设立正常组，模型组，西药阳性对照组，中药阳性对照组，蒿秦通痹胶囊低、中、高剂量组。观察各组血清IgG、TNF-α、IL-1β浓度、胸腺指数、脾脏指数等指标。结果蒿秦通痹胶囊可抑制模型动物血清IgG、TNF-α水平及D4与CD8 T淋巴细胞的异常，可明显降低绵羊红细胞致敏的小鼠脾细胞抗体产生的水平，其胸腺指数和脾脏指数也明显优于模型组（P＜0．05）。结论蒿秦通痹胶囊对Ⅱ型胶原诱导关节炎大鼠的免疫状态有一定的抑制和调节作用，对体液免疫反应有明显的抑制作用。
목적：통과동물실험탐토호진통비효낭항류풍습성관절염적작용궤리。방법분별채용건강Wistar대서、소서복제류풍습관절염모형，설립정상조，모형조，서약양성대조조，중약양성대조조，호진통비효낭저、중、고제량조。관찰각조혈청IgG、TNF-α、IL-1β농도、흉선지수、비장지수등지표。결과호진통비효낭가억제모형동물혈청IgG、TNF-α수평급D4여CD8 T림파세포적이상，가명현강저면양홍세포치민적소서비세포항체산생적수평，기흉선지수화비장지수야명현우우모형조（P＜0．05）。결론호진통비효낭대Ⅱ형효원유도관절염대서적면역상태유일정적억제화조절작용，대체액면역반응유명현적억제작용。
Objective ToexploretheeffectmechanismofHaoqinTongbiCapsulesonrheumatoid arthritisinanimalexperiment.Methods ThehealthWistarratsandmicewereusedtoduplicatethemodels of rheumatoid arthritis.A normal control group,a model group,a western medicine positive control group,a Chinese medicine positive control group,the low -dose,middle -dose and high -dose groups of Haoqin Tongbi Capsules were set up.The concentrations of serum IgG,TNG-αand IL -1β,thymus index and spleenindexwereobservedineachgroup.Results HaoqinTongbiCapsulesinhibitedtheserumlevelsof IgG and TNG-αand the abnormality of D4 and CD8 T lymphocytes,apparently reduced the level of spleen cell antibody sensitized by sheep red blood cell,and the results of thymus index and spleen index were obvi-ouslysuperiortothemodelgroup(P<0.05).Conclusion HaoqinTongbiCapsuleshaveacertaininhibito-ry and regulatory functions to the immune state of the rats with II-collagen induced arthritis and have appar-ent inhibitory function to the body fluid immune reaction.