CAJ | 학술논문

目的：探讨环索奈德与孟鲁司特钠联合治疗对哮喘患者血清中白细胞介素-6（IL-6）、肿瘤坏死因子（TNF-a）及痰液中白三烯（LTs）水平的影响。方法选择200例急性发作期哮喘患者，将其随机分为实验组（100例）和对照组（100例），对照组予以环索奈德治疗；实验组在对照组基础上，加用孟鲁司特钠治疗，服用2周。结果实验组有91％的患者达到临床控制，与对照组的78％相比较，差异有统计学意义（P＜0.05），治疗4周、8周后患者血清中IL-6，TNF-α及痰液中LTs水平均较治疗前明显下降（P＜0.05），且实验组比对照组下降更明显（P＜0.05）。结论环索奈德联合孟鲁司特钠治疗哮喘的作用机制可能是通过下调血清中白介素-6（IL-6）、肿瘤坏死因子（TNF-α）及痰液中白三烯（LTs）的水平。
목적：탐토배색내덕여맹로사특납연합치료대효천환자혈청중백세포개소-6（IL-6）、종류배사인자（TNF-a）급담액중백삼희（LTs）수평적영향。방법선택200례급성발작기효천환자，장기수궤분위실험조（100례）화대조조（100례），대조조여이배색내덕치료；실험조재대조조기출상，가용맹로사특납치료，복용2주。결과실험조유91％적환자체도림상공제，여대조조적78％상비교，차이유통계학의의（P＜0.05），치료4주、8주후환자혈청중IL-6，TNF-α급담액중LTs수평균교치료전명현하강（P＜0.05），차실험조비대조조하강경명현（P＜0.05）。결론배색내덕연합맹로사특납치료효천적작용궤제가능시통과하조혈청중백개소-6（IL-6）、종류배사인자（TNF-α）급담액중백삼희（LTs）적수평。
Objective To explore the level of IL-6, TNF-a and sputum LTs of ciclesonide combined montelukast in the treatment ofasthma.Methods 200patientswithacuteexacerbationofasthmawererandomlydividedintotheexperimentalgroup(100cases)and control group ( 100 cases ).The control group were treated with ciclesonide ,and the experimental group were treatd with ciclesonide com-binedmontelukast.Allpatientsweretreatedfortwoweeks.Results 91patientswithclinicalcontrolintheexperimentalgroup,and78pa-tients with clinical control in the control group (P<0.05),the IL-6, TNF-a and sputum LTs level were decreased significantly (P<0.05),and the experimental group had higher degree of decline.Conclusion Ciclesonide combined montelukast may reduce IL -6, TNF-a and sputum LTs levels in the treatment of serum.